Lactobacillus gasseri cho Helicobacter pylori Infection
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.
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B
Kết luận
Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.
Key Study Findings
In Vitro
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …
Dose: None
so với: H. pylori infection without lactobacilli
Outcome: ADAM17, HBEGF, TGF-alpha expression
Hiệu quả: None
None
Đối tượng nghiên cứu: AGS gastric epithelial cells and mouse model
In Vitro
Lactobacillus gasseri Suppresses the Helicobacter pylori-Induced Hummingbird Phenotype by Inhibiting CagA Phosphorylation and SHP-2 Interaction.
Dose: None
so với: CagA-expressing AGS cells without L. gasseri
Outcome: Suppression of CagA phosphorylation (hummingbird)
Hiệu quả: None
None
Đối tượng nghiên cứu: Human gastric AGS cell line with H. pylori CagA
In Vitro
The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …
Dose: 50 μg/ml
so với: None
Outcome: Inflammatory markers
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Other
Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …
Dose: None
so với: None
Outcome: Inflammatory markers
Hiệu quả: None
None
Đối tượng nghiên cứu: Cancer patients
Other
Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori …
Dose: None
so với: None
Outcome: H. pylori abundance reduction
Hiệu quả: None
None
Đối tượng nghiên cứu: H. pylori-infected C57BL/6 mice
Case-Control
n=178
Oral and gastric microbiome in relation to gastric intestinal metaplasia.
Dose: None
so với: None
Outcome: Oral/gastric microbiome associations with IM
Hiệu quả: None
None
Đối tượng nghiên cứu: Gastric intestinal metaplasia cases and matched controls
Key Statistics
3
Nghiên cứu
350
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
International journal of …
2025
4 trích dẫn
International journal of …
2025
Microbial pathogenesis
2024
8 trích dẫn
Helicobacter
2024
5 trích dẫn
International journal of …
2022
59 trích dẫn
BMC microbiology
2022
28 trích dẫn
Food & function
2022
19 trích dẫn
Probiotics and antimicrobial …
2021
30 trích dẫn
Comparative immunology, microbiology …
2019
72 trích dẫn
Frontiers in immunology
2019
61 trích dẫn
Frontiers in microbiology
2019
31 trích dẫn
BMJ open gastroenterology
2019
14 trích dẫn
Digestion
2017
67 trích dẫn
Gastroenterology research and …
2016
38 trích dẫn
Helicobacter
2015
26 trích dẫn
PloS one
2014
171 trích dẫn
Frontiers in microbiology
2014
78 trích dẫn
Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health.
Review
FEMS microbiology reviews
2013
196 trích dẫn
Journal of gastroenterology …
2012
76 trích dẫn
Journal of food …
2012
56 trích dẫn
Journal of clinical …
2012
37 trích dẫn
Journal of dairy …
2010
43 trích dẫn
Journal of medicinal …
2010
19 trích dẫn
Probiotics and antimicrobial …
2010
9 trích dẫn
Helicobacter
2009
48 trích dẫn
Cellular microbiology
2006
50 trích dẫn
Journal of gastroenterology …
2006
41 trích dẫn
Letters in applied …
2006
26 trích dẫn
Journal of pharmacological …
2004
58 trích dẫn
Journal of gastroenterology …
2003
77 trích dẫn
Effects of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in children.
Other
The Journal of …
2002
31 trích dẫn
The Journal of …
2001
309 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 1-10 billion CFU/day
- gerdsupport:
- 1-5 billion CFU/day
- hpylorisupport:
- 100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks
Giới hạn trên: Well-tolerated up to 10 billion CFU/day in clinical trials
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 50 μg/ml | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | 178 |
| None | -- | Positive | -- |
| 1 g | -- | Positive | -- |
Thời điểm dùng tốt nhất: Before meals or with meals; yogurt form taken with food
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Mild gas during initial use
- ⚠ Occasional loose stools
- ⚠ Rare abdominal discomfort
- ⚠ Very rare: bacteremia in immunocompromised individuals
Tương tác đã biết
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Proton pump inhibitors (altered gastric pH may affect colonization)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
Mức hấp thụ tối đa cho phép: Well-tolerated up to 10 billion CFU/day in clinical trials
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Lactobacillus gasseri help with Helicobacter pylori Infection?
Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus gasseri may support Helicobacter pylori Infection management. Our evidence grade is B (Good Evidence).
How much Lactobacillus gasseri should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus gasseri?
Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus gasseri and Helicobacter pylori Infection?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Helicobacter pylori Infection
Lactobacillus gasseri cho các tình trạng khác
References
- [1] Rajesh K Gupta et al.. Int J Mol Sci. 2025. Lactobacillus gasseri Suppresses the Helicobacter pylori-Induced Hummingbird Phenotype by Inhibiting CagA Phosphorylation and SHP-2 Interaction. doi:10.3390/ijms26146718 PubMed
- [2] Tanvi Somiah et al.. Int J Med Microbiol. 2025. Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells. doi:10.1016/j.ijmm.2025.151694 PubMed
- [3] Zahra Sadeghloo et al.. Microb Pathog. 2024. The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of Helicobacter pylori in gastric epithelial … doi:10.1016/j.micpath.2024.106559 PubMed
- [4] Marine Jauvain et al.. Helicobacter. 2024. Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter pylori Infection. doi:10.1111/hel.13108 PubMed
- [5] Fen Wu et al.. Int J Cancer. 2022. Oral and gastric microbiome in relation to gastric intestinal metaplasia. doi:10.1002/ijc.33848 PubMed
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- [7] Yuyang Zhao et al.. Food Funct. 2022. Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL/6 mice. doi:10.1039/d2fo02034c PubMed
- [8] Mahdieh Yarmohammadi et al.. Probiotics Antimicrob Proteins. 2021. Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected … doi:10.1007/s12602-020-09721-z PubMed
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- [19] Ryuzo Deguchi et al.. J Gastroenterol Hepatol. 2012. Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. doi:10.1111/j.1440-1746.2011.06985.x PubMed
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- [25] Surasak Boonyaritichaikij et al.. Helicobacter. 2009. Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection. doi:10.1111/j.1523-5378.2009.00675.x PubMed
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- [30] Atsushi Ushiyama et al.. J Gastroenterol Hepatol. 2003. Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. doi:10.1046/j.1440-1746.2003.03102.x PubMed
- [31] Toshiaki Shimizu et al.. J Antimicrob Chemother. 2002. Effects of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in children. doi:10.1093/jac/dkf157 PubMed
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