N-Acetyl Cysteine (NAC) için Helicobacter pylori Infection
C Kanıt Küçük çalışmalardan sınırlı kanıt mevcuttur, ancak bazı olumlu sinyaller bulunmaktadır.NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
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C
Sonuç
NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
Key Study Findings
In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL
vs: None
Outcome: anti-Helicobacter pylori activity
Etki: None
None
Popülasyon: None
Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: Published erratum (correction notice)
Review
Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: None
Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None
vs: None
Outcome: Cancer outcomes
Etki: None
None
Popülasyon: Cancer patients
In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None
vs: None
Outcome: choline levels/cognition
Etki: None
None
Popülasyon: Mice
Other
α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human …
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: None
Key Statistics
3
Çalışmalar
250
Katılımcılar
↑
Positive
C
Derece
Referenced Papers
mLife
2026
Biochimica et biophysica …
2025
1 atıf
Oxidative medicine and …
2025
Pharmaceutics
2024
8 atıf
Frontiers in cellular …
2023
7 atıf
Frontiers in cardiovascular …
2022
27 atıf
Nutrients
2022
11 atıf
Microbial drug resistance …
2020
34 atıf
Therapeutic advances in …
2020
7 atıf
Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori.
Other
Molecules (Basel, Switzerland)
2020
Expert review of …
2019
85 atıf
The Cochrane database …
2019
21 atıf
Oxidative medicine and …
2018
93 atıf
The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis.
Meta-Analysis
Helicobacter
2018
18 atıf
N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection.
Other
Journal of microbiology …
2017
16 atıf
Cell host & …
2016
101 atıf
Helicobacter
2016
60 atıf
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2016
25 atıf
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18 atıf
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17 atıf
Pathogens and disease
2015
64 atıf
World journal of …
2015
21 atıf
Journal of cancer …
2013
10 atıf
Alimentary pharmacology & …
2012
104 atıf
Clinical and experimental …
2012
1 atıf
Journal of clinical …
2011
34 atıf
Clinical gastroenterology and …
2010
103 atıf
Pharmaceutical biology
2010
16 atıf
Probiotics and antimicrobial …
2010
9 atıf
American family physician
2009
Helicobacter
2007
130 atıf
World journal of …
2007
77 atıf
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2007
44 atıf
American journal of …
2007
11 atıf
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2004
53 atıf
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2004
4 atıf
Digestive diseases and …
2003
69 atıf
Annals of the …
2002
30 atıf
Journal of environmental …
2002
Pharmacological research
2001
25 atıf
Schweizerische medizinische Wochenschrift
1994
22 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 600-1,200 mg/day in divided doses
- hpyloriadjunct:
- 600 mg twice daily alongside standard triple therapy
- antioxidantsupport:
- 600-900 mg/day
Üst sınır: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| MIC 11 μg/mL | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
En iyi alım zamanı: With or without food; divide doses throughout the day
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Nausea and vomiting (most common, especially at higher doses)
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/odor
- ⚠ Headache
Bilinen Etkileşimler
- ● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
- ● Activated charcoal (may reduce NAC absorption)
- ● Anticoagulants (NAC may have mild antiplatelet effects)
- ● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)
Tolere edilebilir üst alım: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Şu durum için diğer içerikler: Helicobacter pylori Infection
N-Acetyl Cysteine (NAC) diğer sağlık durumları için
References
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