Bifidobacterium bifidum для Functional Dyspepsia

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

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Итог

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

Key Study Findings

Controlled Clinical Trial n=54 3.0 weeks

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with …

Dose: 350 mg или: None Outcome: IBS symptom improvement Эффект: None None

Популяция: Irritable bowel syndrome with diarrhea and antibiotic-associated diarr

Randomized Controlled Trial n=100 4 weeks Double-blind

Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in …

Dose: 100 mL/day fermented milk или: Placebo fermented milk Outcome: GI symptom scores (m-FSSG, GSRS) Эффект: None None

Популяция: Healthy Japanese adults with GI discomfort

Other 4.0 weeks

Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms …

Dose: 100 mL/day или: None Outcome: None Эффект: None None

Популяция: men

Randomized Controlled Trial Double-blind

Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or …

Dose: None или: Placebo + eradication regimen Outcome: H. pylori eradication rate and adverse effects Эффект: None None

Популяция: Adults with H. pylori infection

Key Statistics

Исследования

500

Участники

↑

Positive

Оценка

Referenced Papers

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, … RCT

Journal of dairy … 2018 51 цитирований

Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal … Other

Bioscience of microbiota, … 2015 40 цитирований

Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of … RCT

BMC gastroenterology 2013 70 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 1-10 billion CFU/day
dyspepsiasupport:: 1 billion CFU/day (YIT 10347 strain)

Верхний предел: Well-tolerated up to 10 billion CFU/day in clinical trials

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
350 mg	3.0 weeks	Positive	54
100 mL/day fermented milk	4 weeks	Positive	100
100 mL/day	4.0 weeks	Positive	--
None	--	Neutral	--

Лучшее время приёма: On an empty stomach or before meals

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Mild gas and bloating during initial use
⚠ Occasional abdominal discomfort
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Известные взаимодействия

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

Допустимый верхний уровень потребления: Well-tolerated up to 10 billion CFU/day in clinical trials

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Bifidobacterium bifidum help with Functional Dyspepsia?

Based on 4 studies with 500 participants, there is limited but promising evidence that Bifidobacterium bifidum may support Functional Dyspepsia management. Our evidence grade is C (Some Evidence).

How much Bifidobacterium bifidum should I take for Functional Dyspepsia?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium bifidum?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium bifidum and Functional Dyspepsia?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Другие ингредиенты для Functional Dyspepsia

Ginger B Deglycyrrhizinated Licorice (DGL) C

Краткий вывод

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (2)Meta (0)Other (2)

Сравнить альтернативы

Узнайте, как другие ингредиенты сравниваются при данном состоянии.

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References

[1] V N Drozdov et al.. Vopr Pitan. 2023. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … doi:10.33029/0042-8833-2023-92-4-92-103 PubMed
[2] A Gomi et al.. J Dairy Sci. 2018. Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, … doi:10.3168/jds.2017-13803 PubMed
[3] Yoshihisa Urita et al.. Biosci Microbiota Food Health. 2015. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal … doi:10.12938/bmfh.2014-017 PubMed
[4] Tomás Navarro-Rodriguez et al.. BMC Gastroenterol. 2013. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of … doi:10.1186/1471-230X-13-56 PubMed

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Bifidobacterium bifidum для Functional Dyspepsia

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Итог

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Часто используемые дозировки

Дозировки, изученные в исследованиях

Safety & Side Effects

Зарегистрированные побочные эффекты

Известные взаимодействия

Frequently Asked Questions

Related Evidence

Другие ингредиенты для Functional Dyspepsia

References