Bifidobacterium bifidum for Functional Dyspepsia
C Some Evidence Limited evidence from small studies, but some positive signals exist.B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.
The Bottom Line
B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.
Key Study Findings
Population: Irritable bowel syndrome with diarrhea and antibiotic-associated diarr
Population: Healthy Japanese adults with GI discomfort
Population: men
Population: Adults with H. pylori infection
Key Statistics
4
Studies
500
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 1-10 billion CFU/day
- dyspepsiasupport:
- 1 billion CFU/day (YIT 10347 strain)
Upper limit: Well-tolerated up to 10 billion CFU/day in clinical trials
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| 350 mg | 3.0 weeks | Positive | 54 |
| 100 mL/day fermented milk | 4 weeks | Positive | 100 |
| 100 mL/day | 4.0 weeks | Positive | -- |
| None | -- | Neutral | -- |
Best taken: On an empty stomach or before meals
Safety & Side Effects
Reported Side Effects
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
Known Interactions
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
Tolerable upper intake: Well-tolerated up to 10 billion CFU/day in clinical trials
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Bifidobacterium bifidum help with Functional Dyspepsia?
How much Bifidobacterium bifidum should I take for Functional Dyspepsia?
Are there side effects of Bifidobacterium bifidum?
How strong is the evidence for Bifidobacterium bifidum and Functional Dyspepsia?
Related Evidence
Other ingredients for Functional Dyspepsia
References
- [1] V N Drozdov et al.. Vopr Pitan. 2023. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … doi:10.33029/0042-8833-2023-92-4-92-103 PubMed
- [2] A Gomi et al.. J Dairy Sci. 2018. Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, … doi:10.3168/jds.2017-13803 PubMed
- [3] Yoshihisa Urita et al.. Biosci Microbiota Food Health. 2015. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal … doi:10.12938/bmfh.2014-017 PubMed
- [4] Tomás Navarro-Rodriguez et al.. BMC Gastroenterol. 2013. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of … doi:10.1186/1471-230X-13-56 PubMed
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