Bifidobacterium bifidum ： Functional Dyspepsia

C エビデンス小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

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結論

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

Key Study Findings

Controlled Clinical Trial n=54 3.0 weeks

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with …

Dose: 350 mg vs: None Outcome: IBS symptom improvement 効果: None None

対象集団: Irritable bowel syndrome with diarrhea and antibiotic-associated diarr

Randomized Controlled Trial n=100 4 weeks Double-blind

Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in …

Dose: 100 mL/day fermented milk vs: Placebo fermented milk Outcome: GI symptom scores (m-FSSG, GSRS) 効果: None None

対象集団: Healthy Japanese adults with GI discomfort

Other 4.0 weeks

Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms …

Dose: 100 mL/day vs: None Outcome: None 効果: None None

対象集団: men

Randomized Controlled Trial Double-blind

Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or …

Dose: None vs: Placebo + eradication regimen Outcome: H. pylori eradication rate and adverse effects 効果: None None

対象集団: Adults with H. pylori infection

Key Statistics

研究数

500

参加者数

↑

Positive

グレード

Referenced Papers

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, … RCT

Journal of dairy … 2018 51 件の引用

Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal … Other

Bioscience of microbiota, … 2015 40 件の引用

Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of … RCT

BMC gastroenterology 2013 70 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1-10 billion CFU/day
dyspepsiasupport:: 1 billion CFU/day (YIT 10347 strain)

上限量： Well-tolerated up to 10 billion CFU/day in clinical trials

研究で検討された用量

用量	期間	効果	N
350 mg	3.0 weeks	Positive	54
100 mL/day fermented milk	4 weeks	Positive	100
100 mL/day	4.0 weeks	Positive	--
None	--	Neutral	--

推奨摂取タイミング： On an empty stomach or before meals

Safety & Side Effects

報告されている副作用

⚠ Mild gas and bloating during initial use
⚠ Occasional abdominal discomfort
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

既知の相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

耐容上限摂取量： Well-tolerated up to 10 billion CFU/day in clinical trials

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Bifidobacterium bifidum help with Functional Dyspepsia?

Based on 4 studies with 500 participants, there is limited but promising evidence that Bifidobacterium bifidum may support Functional Dyspepsia management. Our evidence grade is C (Some Evidence).

How much Bifidobacterium bifidum should I take for Functional Dyspepsia?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium bifidum?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium bifidum and Functional Dyspepsia?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

に関する他の成分： Functional Dyspepsia

Ginger B Deglycyrrhizinated Licorice (DGL) C

総合評価

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (2)Meta (0)Other (2)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Functional Dyspepsia

詳しく見る

References

[1] V N Drozdov et al.. Vopr Pitan. 2023. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … doi:10.33029/0042-8833-2023-92-4-92-103 PubMed
[2] A Gomi et al.. J Dairy Sci. 2018. Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, … doi:10.3168/jds.2017-13803 PubMed
[3] Yoshihisa Urita et al.. Biosci Microbiota Food Health. 2015. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal … doi:10.12938/bmfh.2014-017 PubMed
[4] Tomás Navarro-Rodriguez et al.. BMC Gastroenterol. 2013. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of … doi:10.1186/1471-230X-13-56 PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Bifidobacterium bifidum ： Functional Dyspepsia

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： Functional Dyspepsia

References