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L-Glutamine para Increased Intestinal Permeability (Leaky Gut)

D

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

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Conclusão

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

Key Study Findings

Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None vs: None Outcome: Intestinal barrier preservation and repair Efeito: None None

População: IBD and IBS patients (review)

Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None vs: None Outcome: Cholesterol levels Efeito: None None

População: Mouse model

In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None vs: None Outcome: inflammation markers Efeito: None None

População: Mice

Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None vs: None Outcome: None Efeito: None None

População: None

Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None vs: Placebo or standard care Outcome: IBD symptom improvement Efeito: None None

População: IBD patients

Controlled Clinical Trial n=43 4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d vs: None Outcome: None Efeito: None None

População: IBS patients

Key Statistics

2

Estudos

80

Participantes

Positive

D

Nota

Referenced Papers

The Cochrane database … 2016 37 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
5-15 g/day
ibsdsupport:
5 g three times daily (15 g/day total)
postexercisegut:
0.25-0.9 g/kg before intense exercise
gutbarriersupport:
0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite superior: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Positive --
5 g/d 4 weeks Positive 43
5 g 8.0 weeks Positive --
None -- Mixed --

Melhor horário: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Efeitos Colaterais Relatados

  • Mild gastrointestinal discomfort at high doses
  • Headache
  • Dizziness at very high doses
  • Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interações Conhecidas

  • Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
  • Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
  • Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Ingestão máxima tolerável: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Increased Intestinal Permeability (Leaky Gut)

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.