Zinc 관련 Acute Diarrhea
AWHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'gutcited.com';
const params = 'ingredient\u003Dzinc\u0026condition\u003Dacute\u002Ddiarrhea';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
결론
WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.
Key Study Findings
Review
The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries
Other
Clinical practice guidelines for acute infectious diarrhea in children in China (2024).
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Clinical practice guidelines for pediatric acute diarrhea
Randomized Controlled Trial
Open-label
Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea …
Dose: ORS and zinc tablets
vs: Standard care (no reminders)
Outcome: ORS and zinc adherence rates
효과: None
None
대상 집단: Children <5 with acute diarrhea
Review
Lactose intolerance: myths and facts. An update.
Dose: None
vs: None
Outcome: Lactose digestion and tolerance management
효과: None
None
대상 집단: Lactose intolerant individuals
Randomized Controlled Trial
n=454
1 weeks
Double-blind
Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration …
Dose: 2 billion spores/5mL BID x 5 days
vs: Placebo + ORT + zinc
Outcome: Duration of acute diarrhea
효과: Median 42.83h vs 42.13h (HR 0.93, 95%CI 0.77-1.13)
p=0.70
대상 집단: Children 6mo-5y with acute moderate diarrhea in India
Key Statistics
33
연구
10000
참여자
↑
Positive
A
등급
Referenced Papers
BMC pediatrics
2026
World journal of …
2025
2 인용
BMC health services …
2024
1 인용
Archivos argentinos de …
2022
42 인용
Tropical diseases, travel …
2022
17 인용
Nutrition reviews
2022
3 인용
Has Zinc Lost Its Shine?
Other
The Journal of …
2022
ACS infectious diseases
2021
26 인용
Journal of dairy …
2020
58 인용
The New England …
2020
50 인용
Pediatric gastroenterology, hepatology …
2019
17 인용
Cureus
2019
11 인용
Brain and nerve …
2019
1 인용
PloS one
2018
76 인용
World journal of …
2018
52 인용
PloS one
2018
48 인용
Antimicrobial resistance and …
2018
46 인용
Interventions to reduce post-acute consequences of diarrheal disease in children: a systematic review.
Systematic Review
BMC public health
2018
23 인용
Approach to "Upset Stomach".
Review
Indian journal of …
2017
1 인용
Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea.
RCT
The Turkish journal …
2016
36 인용
Allergologia et immunopathologia
2016
31 인용
Current opinion in …
2016
13 인용
Zhongguo dang dai …
2016
9 인용
Systematic reviews
2016
Antimicrobial resistance and …
2015
113 인용
Journal of trace …
2015
33 인용
Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study.
Other
Medical journal of …
2015
15 인용
Zinc supplementation in acute diarrhea.
Meta-Analysis
Indian journal of …
2015
13 인용
Indian journal of …
2015
4 인용
Current gastroenterology reports
2014
40 인용
Expert review of …
2014
37 인용
Advances in nutrition …
2013
807 인용
Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.
Meta-Analysis
Nutrients
2013
89 인용
Annals of nutrition …
2013
82 인용
Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis.
Meta-Analysis
Revista panamericana de …
2013
38 인용
Indian journal of …
2013
26 인용
Journal of clinical …
2013
15 인용
Expert opinion on …
2012
73 인용
Acta scientiarum polonorum. …
2012
11 인용
Current infectious disease …
2012
Current opinion in …
2011
59 인용
Current opinion in …
2011
31 인용
The Journal of …
2011
30 인용
Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review.
Meta-Analysis
PloS one
2010
114 인용
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 인용
Food and nutrition …
2009
313 인용
Zinc deficiency.
Review
Current opinion in …
2009
72 인용
BMC medicine
2009
45 인용
A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea.
Meta-Analysis
Pediatrics
2008
180 인용
Current opinion in …
2008
55 인용
The American journal …
2007
106 인용
Journal of clinical …
2007
48 인용
Nutrition (Burbank, Los …
2007
39 인용
Archives de pediatrie …
2007
13 인용
Gastroenterology
2006
93 인용
Journal of pediatric …
2006
55 인용
Journal of pediatric …
2006
54 인용
Biological trace element …
2006
27 인용
Indian journal of …
2006
25 인용
Zinc and pneumonia.
Other
The American journal …
2006
23 인용
Annals of tropical …
2005
92 인용
Indian pediatrics
2005
The Journal of …
2003
359 인용
Paediatric drugs
2003
125 인용
Cost effectiveness and …
2003
32 인용
Journal of health, …
2003
MMWR. Recommendations and …
2003
Pediatrics
2002
154 인용
The British journal …
2001
74 인용
The British journal …
2001
30 인용
The American journal …
2000
556 인용
The Journal of …
1999
37 인용
JPEN. Journal of …
1999
26 인용
The American journal …
1998
252 인용
The American journal …
1998
121 인용
The American journal …
1998
28 인용
The Journal of …
1998
3 인용
Nederlands tijdschrift voor …
1991
Indian pediatrics
1990
8 인용
Clinica chimica acta; …
1986
15 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 8-11 mg/day (RDA for adults)
- infantdiarrhea:
- 10 mg/day for 10-14 days (WHO recommendation for infants <6 months)
- pediatricdiarrhea:
- 20 mg/day for 10-14 days (WHO recommendation for children >6 months)
- gutbarriersupport:
- 15-30 mg/day elemental zinc
상한량: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| ORS and zinc tablets | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| 2 billion spores/5mL BID x 5 days | 1 weeks | Neutral | 454 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
권장 복용 시간: With food to reduce nausea; space from antibiotics and iron by 2 hours
Safety & Side Effects
보고된 부작용
- ⚠ Nausea and vomiting (most common, especially on empty stomach)
- ⚠ Metallic taste
- ⚠ Copper depletion with long-term supplementation above 40 mg/day
- ⚠ Diarrhea (paradoxically, at high doses)
알려진 상호작용
- ● Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
- ● Penicillamine (zinc reduces absorption; space 2 hours)
- ● Iron supplements (mutual inhibition of absorption; take at different times)
- ● Copper supplements (zinc competes with copper for absorption)
일일 최대 섭취 허용량: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Zinc help with Acute Diarrhea?
Based on 33 studies with 10,000 participants, there is strong evidence from multiple clinical trials that Zinc may support Acute Diarrhea management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Acute Diarrhea?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (most common, especially on empty stomach), Metallic taste, Copper depletion with long-term supplementation above 40 mg/day, Diarrhea (paradoxically, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Acute Diarrhea?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Acute Diarrhea
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.