아연 관련 급성 설사
A 근거 여러 대규모 임상 시험이 일관되게 유의미한 효과를 보여줍니다.WHO와 유니세프는 급성 설사가 있는 모든 소아에게 아연(20mg/일, 10~14일간)을 권장합니다. 설사 지속시간을 약 25% 줄이고 이후 2~3개월간 재발 빈도를 감소시킵니다.
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A
결론
WHO와 유니세프는 급성 설사가 있는 모든 소아에게 아연(20mg/일, 10~14일간)을 권장합니다. 설사 지속시간을 약 25% 줄이고 이후 2~3개월간 재발 빈도를 감소시킵니다.
Key Study Findings
Review
The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries
Other
Clinical practice guidelines for acute infectious diarrhea in children in China (2024).
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Clinical practice guidelines for pediatric acute diarrhea
Randomized Controlled Trial
Open-label
Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea …
Dose: ORS and zinc tablets
vs: Standard care (no reminders)
Outcome: ORS and zinc adherence rates
효과: None
None
대상 집단: Children <5 with acute diarrhea
Review
Lactose intolerance: myths and facts. An update.
Dose: None
vs: None
Outcome: Lactose digestion and tolerance management
효과: None
None
대상 집단: Lactose intolerant individuals
Randomized Controlled Trial
n=454
1 weeks
Double-blind
Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration …
Dose: 2 billion spores/5mL BID x 5 days
vs: Placebo + ORT + zinc
Outcome: Duration of acute diarrhea
효과: Median 42.83h vs 42.13h (HR 0.93, 95%CI 0.77-1.13)
p=0.70
대상 집단: Children 6mo-5y with acute moderate diarrhea in India
Key Statistics
33
연구
10000
참여자
↑
Positive
A
등급
Referenced Papers
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2026
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1 인용
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2022
17 인용
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2022
3 인용
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Other
The Journal of …
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2021
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50 인용
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Zinc deficiency.
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2009
72 인용
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Biological trace element …
2006
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Indian journal of …
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Other
The American journal …
2006
23 인용
Annals of tropical …
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 8-11 mg/day (RDA for adults)
- infantdiarrhea:
- 10 mg/day for 10-14 days (WHO recommendation for infants <6 months)
- pediatricdiarrhea:
- 20 mg/day for 10-14 days (WHO recommendation for children >6 months)
- gutbarriersupport:
- 15-30 mg/day elemental zinc
상한량: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| ORS and zinc tablets | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| 2 billion spores/5mL BID x 5 days | 1 weeks | Neutral | 454 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
권장 복용 시간: With food to reduce nausea; space from antibiotics and iron by 2 hours
Safety & Side Effects
보고된 부작용
- ⚠ Nausea and vomiting (most common, especially on empty stomach)
- ⚠ Metallic taste
- ⚠ Copper depletion with long-term supplementation above 40 mg/day
- ⚠ Diarrhea (paradoxically, at high doses)
알려진 상호작용
- ● Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
- ● Penicillamine (zinc reduces absorption; space 2 hours)
- ● Iron supplements (mutual inhibition of absorption; take at different times)
- ● Copper supplements (zinc competes with copper for absorption)
일일 최대 섭취 허용량: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does 아연 help with 급성 설사?
Based on 33 studies with 10,000 participants, there is strong evidence from multiple clinical trials that 아연 may support 급성 설사 management. Our evidence grade is A (Strong Evidence).
How much 아연 should I take for 급성 설사?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 아연?
Reported side effects may include Nausea and vomiting (most common, especially on empty stomach), Metallic taste, Copper depletion with long-term supplementation above 40 mg/day, Diarrhea (paradoxically, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 아연 and 급성 설사?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.
Related Evidence
References
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FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.