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Zinc para Acute Diarrhea

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WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.

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Conclusión

WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.

Key Study Findings

Review
The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …
Dose: None vs: None Outcome: None Efecto: None None

Población: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries

Other
Clinical practice guidelines for acute infectious diarrhea in children in China (2024).
Dose: None vs: None Outcome: None Efecto: None None

Población: Clinical practice guidelines for pediatric acute diarrhea

Randomized Controlled Trial Open-label
Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea …
Dose: ORS and zinc tablets vs: Standard care (no reminders) Outcome: ORS and zinc adherence rates Efecto: None None

Población: Children <5 with acute diarrhea

Other
Has Zinc Lost Its Shine?
Dose: None vs: None Outcome: None Efecto: None None

Población: None

Review
Lactose intolerance: myths and facts. An update.
Dose: None vs: None Outcome: Lactose digestion and tolerance management Efecto: None None

Población: Lactose intolerant individuals

Randomized Controlled Trial n=454 1 weeks Double-blind
Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration …
Dose: 2 billion spores/5mL BID x 5 days vs: Placebo + ORT + zinc Outcome: Duration of acute diarrhea Efecto: Median 42.83h vs 42.13h (HR 0.93, 95%CI 0.77-1.13) p=0.70

Población: Children 6mo-5y with acute moderate diarrhea in India

Key Statistics

33

Estudios

10000

Participantes

Positive

A

Calificación

Referenced Papers

Archivos argentinos de … 2022 42 citas
The Journal of … 2022
Pediatric gastroenterology, hepatology … 2019 17 citas
Brain and nerve … 2019 1 citas
Indian journal of … 2017 1 citas
Current opinion in … 2016 13 citas
Journal of trace … 2015 33 citas
Indian journal of … 2015 13 citas
Current gastroenterology reports 2014 40 citas
Annals of nutrition … 2013 82 citas
Indian journal of … 2013 26 citas
Acta scientiarum polonorum. … 2012 11 citas
Current infectious disease … 2012
Current opinion in … 2011 59 citas
Current opinion in … 2011 31 citas
Current opinion in … 2009 72 citas
Archives de pediatrie … 2007 13 citas
Biological trace element … 2006 27 citas
Indian journal of … 2006 25 citas
The American journal … 2006 23 citas
Annals of tropical … 2005 92 citas
Paediatric drugs 2003 125 citas
The British journal … 2001 74 citas
The Journal of … 1999 37 citas
JPEN. Journal of … 1999 26 citas
The American journal … 1998 121 citas
The American journal … 1998 28 citas
The Journal of … 1998 3 citas
Nederlands tijdschrift voor … 1991
Clinica chimica acta; … 1986 15 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:
8-11 mg/day (RDA for adults)
infantdiarrhea:
10 mg/day for 10-14 days (WHO recommendation for infants <6 months)
pediatricdiarrhea:
20 mg/day for 10-14 days (WHO recommendation for children >6 months)
gutbarriersupport:
15-30 mg/day elemental zinc

Límite superior: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
None -- Neutral --
None -- Mixed --
ORS and zinc tablets -- Positive --
None -- Mixed --
None -- Neutral --
2 billion spores/5mL BID x 5 days 1 weeks Neutral 454
None -- Positive --
None -- Positive --

Mejor momento para tomar: With food to reduce nausea; space from antibiotics and iron by 2 hours

Safety & Side Effects

Efectos secundarios reportados

  • Nausea and vomiting (most common, especially on empty stomach)
  • Metallic taste
  • Copper depletion with long-term supplementation above 40 mg/day
  • Diarrhea (paradoxically, at high doses)

Interacciones conocidas

  • Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
  • Penicillamine (zinc reduces absorption; space 2 hours)
  • Iron supplements (mutual inhibition of absorption; take at different times)
  • Copper supplements (zinc competes with copper for absorption)

Ingesta máxima tolerable: 40 mg/day elemental zinc for adults (risk of copper depletion above this level)

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Zinc help with Acute Diarrhea?
Based on 33 studies with 10,000 participants, there is strong evidence from multiple clinical trials that Zinc may support Acute Diarrhea management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Acute Diarrhea?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (most common, especially on empty stomach), Metallic taste, Copper depletion with long-term supplementation above 40 mg/day, Diarrhea (paradoxically, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Acute Diarrhea?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Acute Diarrhea

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.