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Zinc Carnosine 用于 Peptic Ulcer Disease

B

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

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            B

        

        

            
结论

            
            
Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=92
                
                
                
            

            
                Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A …
            
            

                
                Dose: Zinc carnosine 75 mg twice daily for 10 days
                
                
                vs: Standard triple therapy for 14 days
                
                
                Outcome: H. pylori eradication rate
                
                
                效果: 93.5% vs 69.6%
                
                
                P=0.003
                
            

            
            
研究人群: Dyspepsia patients with H. pylori infection

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.
            
            

                
                Dose: 30 mg/kg
                
                
                vs: None
                
                
                Outcome: mineral status
                
                
                效果: or 2
                
                
                None
                
            

            
            
研究人群: animal model

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
研究数量

    

    

        
500

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        World journal of …
                        2022
                        
                        8 次引用
                        
                    

                

                
                

                    

                        
                            The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Life sciences
                        1991
                        
                        52 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
75 mg twice daily (as zinc carnosine complex)

                    

                    
                    

                        
nsaidprotection:

                        
37.5-75 mg twice daily alongside NSAID therapy

                    

                    
                    

                        
gastricprotection:

                        
75 mg twice daily for 8 weeks

                    

                    
                

                
                

                    上限： 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                Zinc carnosine 75 mg twice daily for 10 days
                                --
                                
                                    
                                    Positive
                                    
                                
                                92
                            

                            
                            

                                30 mg/kg
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： On an empty stomach or between meals for gastric mucosal contact; twice daily
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Nausea (most common, usually transient)
                        
    • 
                        
                        
  • 
                            ⚠
                            Metallic taste
                        
    • 
                        
                        
  • 
                            ⚠
                            Copper depletion with long-term high-dose use (>40 mg elemental zinc/day)
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
                        
    • 
                        
                        
  • 
                            ●
                            Penicillamine (zinc reduces absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Copper supplements (zinc competes with copper for absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Bisphosphonates (zinc may reduce absorption; space 2 hours)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Zinc Carnosine help with Peptic Ulcer Disease?
            
        
        

            Based on 6 studies with 500 participants, there is moderate evidence from clinical studies that Zinc Carnosine may support Peptic Ulcer Disease management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Zinc Carnosine should I take for Peptic Ulcer Disease?
            
        
        

            Studies have used various dosages. A commonly studied range is 75 mg twice daily (as zinc carnosine complex). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Zinc Carnosine?
            
        
        

            Reported side effects may include Nausea (most common, usually transient), Metallic taste, Copper depletion with long-term high-dose use (>40 mg elemental zinc/day), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Zinc Carnosine and Peptic Ulcer Disease?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
其他成分用于 Peptic Ulcer Disease

                    

                        
                        
                            Deglycyrrhizinated Licorice (DGL)
                            C

                        
                        
                    

                

                

                
                

                    
Zinc Carnosine 用于其他健康状况

                    

                        
                        
                            Increased Intestinal Permeability (Leaky Gut)
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

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