Peppermint Oil untuk Irritable Bowel Syndrome (IBS)
AMeta-analyses of 12+ RCTs demonstrate peppermint oil (450-750 mg/day enteric-coated) significantly reduces IBS abdominal pain (RR 1.78 vs placebo). A-grade evidence for global IBS symptom improvement. ACG conditional recommendation.
Kesimpulan
Meta-analyses of 12+ RCTs demonstrate peppermint oil (450-750 mg/day enteric-coated) significantly reduces IBS abdominal pain (RR 1.78 vs placebo). A-grade evidence for global IBS symptom improvement. ACG conditional recommendation.
Key Study Findings
Populasi: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)
Populasi: Patients with functional bloating/distension (consensus)
Populasi: Patients with functional dyspepsia and IBS (review)
Populasi: Review of herbal remedies for IBS
Populasi: Patients with IBS (review)
Populasi: Patients with irritable bowel syndrome
Key Statistics
19
Studi
2569
Peserta
Positive
Peringkat
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 450-750 mg/day enteric-coated capsules
- ibssymptomsupport:
- 187-225 mg enteric-coated capsules, 2-3 times daily, 30-60 min before meals
Batas atas: Well-tolerated up to 1,200 mg/day in clinical trials; enteric coating essential
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: 30-60 minutes before meals; enteric-coated capsules MUST be swallowed whole (do not chew or crush)
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Heartburn/GERD exacerbation (if non-enteric-coated; relaxes lower esophageal sphincter)
- ⚠ Perianal burning sensation (from undigested menthol reaching the rectum)
- ⚠ Nausea at high doses
- ⚠ Allergic reactions in mint-sensitive individuals
Interaksi yang Diketahui
- ● Cyclosporine (peppermint may increase cyclosporine levels via CYP3A4 inhibition)
- ● Antacids and PPIs (may dissolve enteric coating prematurely; space 2 hours)
- ● Simethicone (coated formulations may interact with enteric-coated peppermint)
- ● CYP2C19 substrates (menthol is a weak CYP inhibitor)
Asupan atas yang dapat ditoleransi: Well-tolerated up to 1,200 mg/day in clinical trials; enteric coating essential
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Peppermint Oil help with Irritable Bowel Syndrome (IBS)?
How much Peppermint Oil should I take for Irritable Bowel Syndrome (IBS)?
Are there side effects of Peppermint Oil?
How strong is the evidence for Peppermint Oil and Irritable Bowel Syndrome (IBS)?
Related Evidence
Bahan lain untuk Irritable Bowel Syndrome (IBS)
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