Lactobacillus acidophilus ： Irritable Bowel Syndrome (IBS)

Q: Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

Q: How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

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結論

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Key Study Findings

Randomized Controlled Trial n=200 12 weeks Double-blind

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable …

Dose: None vs: placebo Outcome: IBS-Global Improvement Scale response 効果: 19.3% vs 8.9% response at day 28 p=0.048

対象集団: adults with non-constipated irritable bowel syndrome

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None vs: placebo Outcome: quality of life, depression, and anxiety in IBS … 効果: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

対象集団: patients with irritable bowel syndrome

Randomized Controlled Trial n=61 12 weeks Double-blind

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …

Dose: None vs: Placebo Outcome: IBS-SSS (100-point reduction) 効果: 45% active vs 33% placebo (P=0.42) P=0.42

対象集団: IBD patients with IBS symptoms in remission

Randomized Controlled Trial n=110 12 weeks Double-blind

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for …

Dose: 10^9 CFU L. acidophilus LA-5 + L. paracasei daily vs: Placebo cultured milk Outcome: Depression risk and serotonin levels in IBS patients 効果: None <0.001 (depression score)

対象集団: IBS patients with normal mood and subthreshold depression

In Vitro

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …

Dose: None vs: None Outcome: Colitis severity 効果: None None

対象集団: Crohn's disease patients

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g vs: Placebo Outcome: Constipation symptoms 効果: None P = 0.005

対象集団: IBS patients

Key Statistics

研究数

350

参加者数

↑

Positive

グレード

Referenced Papers

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized … RCT

Journal of gastroenterology … 2026 1 件の引用

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation … Other

World journal of … 2025 2 件の引用

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. RCT

Scientific reports 2024 20 件の引用

Computational prediction of new therapeutic effects of probiotics. Other

Scientific reports 2024 10 件の引用

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 件の引用

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … Other

Journal of clinical … 2024 4 件の引用

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 件の引用

A Synbiotic Combining Chitin-Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an … Other

International journal of … 2024 2 件の引用

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Meta-Analysis

Nutrients 2023 33 件の引用

Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. Other

Anaerobe 2023 14 件の引用

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 件の引用

Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Other

Minerva pediatrics 2023 2 件の引用

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 件の引用

Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis. Systematic Review

Nutrients 2022 19 件の引用

Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study. Other

Gastroenterology research and … 2022 15 件の引用

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 件の引用

Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Other

Acta gastro-enterologica Belgica 2021 14 件の引用

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. RCT

Nutrients 2020 99 件の引用

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … RCT

Nutrients 2020 78 件の引用

A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. RCT

Digestive and liver … 2020 28 件の引用

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future … Review

Cellular and molecular … 2020 4 件の引用

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 件の引用

Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model. Other

BMC complementary and … 2019 24 件の引用

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Review

Diseases (Basel, Switzerland) 2018 50 件の引用

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. RCT

Beneficial microbes 2018 48 件の引用

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells. Other

Saudi journal of … 2018 41 件の引用

Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. RCT

Cellular and molecular … 2017 9 件の引用

Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. RCT

World journal of … 2016 99 件の引用

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of … RCT

Journal of dairy … 2016 67 件の引用

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 件の引用

Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. RCT

Journal of gastroenterology … 2014 164 件の引用

[Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind … Review

Orvosi hetilap 2014 6 件の引用

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 件の引用

Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. RCT

Scandinavian journal of … 2013 74 件の引用

A meta-analysis of probiotic efficacy for gastrointestinal diseases. Meta-Analysis

PloS one 2012 445 件の引用

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 件の引用

[Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome]. RCT

Revista de gastroenterologia … 2012

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 件の引用

Probiotics in irritable bowel syndrome: underachievers or underpowered? Other

Alimentary pharmacology & … 2010 4 件の引用

B-cell activation in patients with irritable bowel syndrome (IBS). Other

Neurogastroenterology and motility 2009 81 件の引用

Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Other

Gut and liver 2009 77 件の引用

Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. RCT

Digestive diseases and … 2008 160 件の引用

Probiotics in functional gastrointestinal disorders: what are the facts? Review

Current opinion in … 2008 68 件の引用

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Other

Nature medicine 2007 774 件の引用

Treatment of irritable bowel syndrome. A case control experience. Other

Minerva gastroenterologica e … 2006 22 件の引用

Bacteriotherapy using fecal flora: toying with human motions. Review

Journal of clinical … 2004 298 件の引用

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 件の引用

Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. RCT

The American journal … 1983 78 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1-10 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
lactosesupport:: 1-2 billion CFU with dairy consumption

上限量： Generally well-tolerated up to 20 billion CFU/day

研究で検討された用量

用量	期間	効果	N
None	12 weeks	Positive	200
None	--	Positive	3154
None	12 weeks	Neutral	61
10^9 CFU L. acidophilus LA-5 + L. paracasei daily	12 weeks	Positive	110
None	--	Positive	--
2 g	4 weeks	Mixed	--
Chitin-glucan + L. acidophilus NCFM	9 weeks	Positive	--
None	--	Neutral	--

推奨摂取タイミング： On an empty stomach or before meals; may also be taken with dairy

Safety & Side Effects

報告されている副作用

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains)
⚠ Very rare: bacteremia in immunocompromised individuals

既知の相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Sulfasalazine (may affect bacterial metabolism)

耐容上限摂取量： Generally well-tolerated up to 20 billion CFU/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

総合評価

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Evidence Strength72%

High confidence

研究の内訳

RCT (17)Meta (4)Other (0)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Irritable Bowel Syndrome (IBS)

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