Lactobacillus acidophilus لـ Irritable Bowel Syndrome (IBS)
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.
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B
الخلاصة
Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.
Key Study Findings
Randomized Controlled Trial
n=200
12 weeks
Double-blind
Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable …
Dose: None
مقابل: placebo
Outcome: IBS-Global Improvement Scale response
التأثير: 19.3% vs 8.9% response at day 28
p=0.048
المجتمع المدروس: adults with non-constipated irritable bowel syndrome
Meta-Analysis
n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None
مقابل: placebo
Outcome: quality of life, depression, and anxiety in IBS …
التأثير: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression)
None
المجتمع المدروس: patients with irritable bowel syndrome
Randomized Controlled Trial
n=61
12 weeks
Double-blind
Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …
Dose: None
مقابل: Placebo
Outcome: IBS-SSS (100-point reduction)
التأثير: 45% active vs 33% placebo (P=0.42)
P=0.42
المجتمع المدروس: IBD patients with IBS symptoms in remission
Randomized Controlled Trial
4 weeks
Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …
Dose: 2 g
مقابل: Placebo
Outcome: Constipation symptoms
التأثير: None
P = 0.005
المجتمع المدروس: IBS patients
Randomized Controlled Trial
12 weeks
Double-blind
Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides …
Dose: None
مقابل: Placebo
Outcome: Quality of life
التأثير: None
p = 0.023
المجتمع المدروس: IBS patients
Other
Computational prediction of new therapeutic effects of probiotics.
Dose: None
مقابل: None
Outcome: Colitis severity
التأثير: None
None
المجتمع المدروس: Crohn's disease patients
Key Statistics
3
الدراسات
350
المشاركون
↑
Positive
B
التقييم
Referenced Papers
Journal of gastroenterology …
2026
1 اقتباسات
European journal of …
2026
World journal of …
2025
2 اقتباسات
Scientific reports
2024
20 اقتباسات
Scientific reports
2024
10 اقتباسات
The Yale journal …
2024
5 اقتباسات
Journal of clinical …
2024
4 اقتباسات
Journal of neurogastroenterology …
2024
4 اقتباسات
International journal of …
2024
2 اقتباسات
Nutrients
2023
33 اقتباسات
Anaerobe
2023
14 اقتباسات
International journal of …
2023
9 اقتباسات
Minerva pediatrics
2023
2 اقتباسات
Voprosy pitaniia
2023
Journal of neurogastroenterology …
2022
21 اقتباسات
Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis.
Systematic Review
Nutrients
2022
19 اقتباسات
Gastroenterology research and …
2022
15 اقتباسات
Microorganisms
2021
47 اقتباسات
Acta gastro-enterologica Belgica
2021
14 اقتباسات
Nutrients
2020
99 اقتباسات
Nutrients
2020
78 اقتباسات
Digestive and liver …
2020
28 اقتباسات
Cellular and molecular …
2020
4 اقتباسات
Probiotics and antimicrobial …
2019
43 اقتباسات
Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model.
Other
BMC complementary and …
2019
24 اقتباسات
Diseases (Basel, Switzerland)
2018
50 اقتباسات
Beneficial microbes
2018
48 اقتباسات
Saudi journal of …
2018
41 اقتباسات
Cellular and molecular …
2017
9 اقتباسات
World journal of …
2016
99 اقتباسات
Journal of dairy …
2016
67 اقتباسات
Journal of clinical …
2015
62 اقتباسات
Journal of gastroenterology …
2014
164 اقتباسات
Orvosi hetilap
2014
6 اقتباسات
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 اقتباسات
Scandinavian journal of …
2013
74 اقتباسات
PloS one
2012
445 اقتباسات
Journal of clinical …
2012
207 اقتباسات
Revista de gastroenterologia …
2012
Journal of clinical …
2011
163 اقتباسات
Alimentary pharmacology & …
2010
4 اقتباسات
Neurogastroenterology and motility
2009
81 اقتباسات
Gut and liver
2009
77 اقتباسات
Digestive diseases and …
2008
160 اقتباسات
Current opinion in …
2008
68 اقتباسات
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.
Other
Nature medicine
2007
774 اقتباسات
Minerva gastroenterologica e …
2006
22 اقتباسات
Journal of clinical …
2004
298 اقتباسات
Journal of clinical …
2004
205 اقتباسات
The American journal …
1983
78 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1-10 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- lactosesupport:
- 1-2 billion CFU with dairy consumption
الحد الأعلى: Generally well-tolerated up to 20 billion CFU/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | 12 weeks | Positive | 200 |
| None | -- | Positive | 3154 |
| None | 12 weeks | Neutral | 61 |
| 2 g | 4 weeks | Mixed | -- |
| None | 12 weeks | Positive | -- |
| None | -- | Neutral | -- |
| 10^9 CFU L. acidophilus LA-5 + L. paracasei daily | 12 weeks | Positive | 110 |
| None | -- | Positive | -- |
أفضل وقت للتناول: On an empty stomach or before meals; may also be taken with dairy
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional loose stools
- ⚠ Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains)
- ⚠ Very rare: bacteremia in immunocompromised individuals
التفاعلات المعروفة
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
- ● Sulfasalazine (may affect bacterial metabolism)
الحد الأقصى المسموح به: Generally well-tolerated up to 20 billion CFU/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus acidophilus?
Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Irritable Bowel Syndrome (IBS)
References
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