Lactobacillus acidophilus के लिए Irritable Bowel Syndrome (IBS)

Q: Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

Q: How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

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निष्कर्ष

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Key Study Findings

Randomized Controlled Trial n=200 12 weeks Double-blind

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable …

Dose: None बनाम: placebo Outcome: IBS-Global Improvement Scale response प्रभाव: 19.3% vs 8.9% response at day 28 p=0.048

जनसंख्या: adults with non-constipated irritable bowel syndrome

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None बनाम: placebo Outcome: quality of life, depression, and anxiety in IBS … प्रभाव: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

जनसंख्या: patients with irritable bowel syndrome

Randomized Controlled Trial n=61 12 weeks Double-blind

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …

Dose: None बनाम: Placebo Outcome: IBS-SSS (100-point reduction) प्रभाव: 45% active vs 33% placebo (P=0.42) P=0.42

जनसंख्या: IBD patients with IBS symptoms in remission

Randomized Controlled Trial n=110 12 weeks Double-blind

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for …

Dose: 10^9 CFU L. acidophilus LA-5 + L. paracasei daily बनाम: Placebo cultured milk Outcome: Depression risk and serotonin levels in IBS patients प्रभाव: None <0.001 (depression score)

जनसंख्या: IBS patients with normal mood and subthreshold depression

In Vitro

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …

Dose: None बनाम: None Outcome: Colitis severity प्रभाव: None None

जनसंख्या: Crohn's disease patients

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g बनाम: Placebo Outcome: Constipation symptoms प्रभाव: None P = 0.005

जनसंख्या: IBS patients

Key Statistics

अध्ययन

350

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized … RCT

Journal of gastroenterology … 2026 1 उद्धरण

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation … Other

World journal of … 2025 2 उद्धरण

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. RCT

Scientific reports 2024 20 उद्धरण

Computational prediction of new therapeutic effects of probiotics. Other

Scientific reports 2024 10 उद्धरण

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 उद्धरण

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … Other

Journal of clinical … 2024 4 उद्धरण

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 उद्धरण

A Synbiotic Combining Chitin-Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an … Other

International journal of … 2024 2 उद्धरण

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Meta-Analysis

Nutrients 2023 33 उद्धरण

Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. Other

Anaerobe 2023 14 उद्धरण

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 उद्धरण

Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Other

Minerva pediatrics 2023 2 उद्धरण

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 उद्धरण

Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis. Systematic Review

Nutrients 2022 19 उद्धरण

Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study. Other

Gastroenterology research and … 2022 15 उद्धरण

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 उद्धरण

Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Other

Acta gastro-enterologica Belgica 2021 14 उद्धरण

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. RCT

Nutrients 2020 99 उद्धरण

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … RCT

Nutrients 2020 78 उद्धरण

A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. RCT

Digestive and liver … 2020 28 उद्धरण

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future … Review

Cellular and molecular … 2020 4 उद्धरण

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 उद्धरण

Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model. Other

BMC complementary and … 2019 24 उद्धरण

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Review

Diseases (Basel, Switzerland) 2018 50 उद्धरण

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. RCT

Beneficial microbes 2018 48 उद्धरण

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells. Other

Saudi journal of … 2018 41 उद्धरण

Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. RCT

Cellular and molecular … 2017 9 उद्धरण

Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. RCT

World journal of … 2016 99 उद्धरण

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of … RCT

Journal of dairy … 2016 67 उद्धरण

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 उद्धरण

Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. RCT

Journal of gastroenterology … 2014 164 उद्धरण

[Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind … Review

Orvosi hetilap 2014 6 उद्धरण

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 उद्धरण

Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. RCT

Scandinavian journal of … 2013 74 उद्धरण

A meta-analysis of probiotic efficacy for gastrointestinal diseases. Meta-Analysis

PloS one 2012 445 उद्धरण

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 उद्धरण

[Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome]. RCT

Revista de gastroenterologia … 2012

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 उद्धरण

Probiotics in irritable bowel syndrome: underachievers or underpowered? Other

Alimentary pharmacology & … 2010 4 उद्धरण

B-cell activation in patients with irritable bowel syndrome (IBS). Other

Neurogastroenterology and motility 2009 81 उद्धरण

Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Other

Gut and liver 2009 77 उद्धरण

Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. RCT

Digestive diseases and … 2008 160 उद्धरण

Probiotics in functional gastrointestinal disorders: what are the facts? Review

Current opinion in … 2008 68 उद्धरण

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Other

Nature medicine 2007 774 उद्धरण

Treatment of irritable bowel syndrome. A case control experience. Other

Minerva gastroenterologica e … 2006 22 उद्धरण

Bacteriotherapy using fecal flora: toying with human motions. Review

Journal of clinical … 2004 298 उद्धरण

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 उद्धरण

Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. RCT

The American journal … 1983 78 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 1-10 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
lactosesupport:: 1-2 billion CFU with dairy consumption

अधिकतम सीमा: Generally well-tolerated up to 20 billion CFU/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	12 weeks	Positive	200
None	--	Positive	3154
None	12 weeks	Neutral	61
10^9 CFU L. acidophilus LA-5 + L. paracasei daily	12 weeks	Positive	110
None	--	Positive	--
2 g	4 weeks	Mixed	--
Chitin-glucan + L. acidophilus NCFM	9 weeks	Positive	--
None	--	Neutral	--

सेवन का सर्वोत्तम समय: On an empty stomach or before meals; may also be taken with dairy

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains)
⚠ Very rare: bacteremia in immunocompromised individuals

ज्ञात अंतःक्रियाएँ

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Sulfasalazine (may affect bacterial metabolism)

सहनीय अधिकतम सेवन: Generally well-tolerated up to 20 billion CFU/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

संक्षिप्त निष्कर्ष

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Evidence Strength72%

High confidence

अध्ययन विश्लेषण

RCT (17)Meta (4)Other (0)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Irritable Bowel Syndrome (IBS)

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।