Omega-3 Fatty Acids (EPA/DHA) 用于 Crohn's Disease
CEPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
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C
结论
EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
Key Study Findings
Other
Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. …
Dose: 50, 100, and 200 mg/kg oral
vs: Dexamethasone 2.4 mg/kg; DNBS colitis model vs healthy
Outcome: Colonic inflammation markers (MPO, NO, MDA, CAT, GSH)
效果: None
None
研究人群: DNBS-induced Crohn's disease BALB/c mouse model
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
vs: None
Outcome: IBD microbiota modulation and immune regulation
效果: None
None
研究人群: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
效果: None
None
研究人群: Vegan athletes (narrative review)
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Diet-genetics interaction in IBD
效果: None
None
研究人群: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
效果: None
None
研究人群: Crohn's disease patients
Observational Study
Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: …
Dose: 95%
vs: None
Outcome: inflammation markers
效果: None
None
研究人群: None
Key Statistics
6
研究数量
800
受试者
↔
Mixed
C
等级
Referenced Papers
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2025
4 次引用
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2018
67 次引用
International journal of …
2017
143 次引用
Medical principles and …
2017
45 次引用
Ugeskrift for laeger
2017
European journal of …
2016
79 次引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 次引用
Clinics in dermatology
2016
19 次引用
The Cochrane database …
2014
88 次引用
Alimentary pharmacology & …
2013
128 次引用
The British journal …
2012
145 次引用
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 次引用
World journal of …
2012
113 次引用
Frontline gastroenterology
2012
20 次引用
Pediatrics in review
2012
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
The American journal …
2011
946 次引用
Inflammatory bowel diseases
2011
195 次引用
Nutrition in clinical …
2011
1 次引用
The Cochrane database …
2009
198 次引用
Review article: the evidence base for interventions used to maintain remission in Crohn's disease.
Review
Alimentary pharmacology & …
2008
50 次引用
The American journal …
2007
310 次引用
Digestion
2007
15 次引用
The Cochrane database …
2007
2 次引用
Gastroenterology nursing : …
2006
24 次引用
World journal of …
2005
80 次引用
Alimentary pharmacology & …
2005
50 次引用
Immunonutrition.
Review
Current opinion in …
2005
22 次引用
Nutricion hospitalaria
2003
Journal of the …
2002
2016 次引用
Enteral feeding.
Other
Current opinion in …
2002
1 次引用
Enteral feeding.
Review
Current opinion in …
2002
Zeitschrift fur Gastroenterologie
1998
18 次引用
Scandinavian journal of …
1996
195 次引用
Arquivos de gastroenterologia
1996
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
上限： 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 50, 100, and 200 mg/kg oral | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| None | -- | Mixed | 12194 |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
可耐受最高摄入量： 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Crohn's Disease?
Based on 6 studies with 800 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 Crohn's Disease
Omega-3 Fatty Acids (EPA/DHA) 用于其他健康状况
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