Omega-3 Fatty Acids (EPA/DHA) untuk Crohn's Disease

EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.

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Kesimpulan

EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.

Key Study Findings

Other

Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. …

Dose: 50, 100, and 200 mg/kg oral vs: Dexamethasone 2.4 mg/kg; DNBS colitis model vs healthy Outcome: Colonic inflammation markers (MPO, NO, MDA, CAT, GSH) Efek: None None

Populasi: DNBS-induced Crohn's disease BALB/c mouse model

Review

Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.

Dose: None vs: None Outcome: IBD microbiota modulation and immune regulation Efek: None None

Populasi: IBD patients (review of nutritional interventions)

Review

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.

Dose: None vs: None Outcome: Athletic performance and nutritional optimization Efek: None None

Populasi: Vegan athletes (narrative review)

Other

Interaction between diet and genetics in patients with inflammatory bowel disease.

Dose: None vs: None Outcome: Diet-genetics interaction in IBD Efek: None None

Populasi: IBD patients (editorial commentary)

Review

Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …

Dose: None vs: None Outcome: Colitis severity Efek: None None

Populasi: Crohn's disease patients

Observational Study

Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: …

Dose: 95% vs: None Outcome: inflammation markers Efek: None None

Populasi: None

Key Statistics

Studi

800

Peserta

↔

Mixed

Peringkat

Referenced Papers

Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit. Review

Semergen 2025 4 sitasi

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 sitasi

Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. (flaxseed) in vivo. Other

Journal of ethnopharmacology 2025 1 sitasi

Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Review

Autoimmunity reviews 2024 12 sitasi

Interaction between diet and genetics in patients with inflammatory bowel disease. Other

World journal of … 2024

Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study. Other

Metabolites 2023 13 sitasi

Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study. Other

Scientific reports 2020 56 sitasi

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 sitasi

The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives. Review

International journal of … 2017 143 sitasi

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal. Other

Medical principles and … 2017 45 sitasi

[Nutrition and dietary supplement in chronic inflammatory bowel diesease]. Review

Ugeskrift for laeger 2017

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease. Review

European journal of … 2016 79 sitasi

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 sitasi

Nutrition and skin: Kids are not just little people. Review

Clinics in dermatology 2016 19 sitasi

Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Systematic Review

The Cochrane database … 2014 88 sitasi

Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Systematic Review

Alimentary pharmacology & … 2013 128 sitasi

Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Systematic Review

The British journal … 2012 145 sitasi

Dietary supplements for established atopic eczema. Meta-Analysis

The Cochrane database … 2012 130 sitasi

Impact of environmental and dietary factors on the course of inflammatory bowel disease. Review

World journal of … 2012 113 sitasi

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 sitasi

Complementary, holistic, and integrative medicine: Crohn disease. Review

Pediatrics in review 2012

Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Systematic Review

The American journal … 2011 946 sitasi

Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Meta-Analysis

Inflammatory bowel diseases 2011 195 sitasi

Comment On: Maintenance of Remission in Inflammatory Bowel Disease Using Omega-3 Fatty Acids (Fish Oil): A Systematic Review and Meta-Analyses. Other

Nutrition in clinical … 2011 1 sitasi

Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2009 198 sitasi

Review article: the evidence base for interventions used to maintain remission in Crohn's disease. Review

Alimentary pharmacology & … 2008 50 sitasi

Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn's disease in children. Other

The American journal … 2007 310 sitasi

Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin … RCT

Digestion 2007 15 sitasi

Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2007 2 sitasi

Omega-3 fatty acids as adjunctive therapy in Crohns disease. Review

Gastroenterology nursing : … 2006 24 sitasi

Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: a double-blind, randomized, … RCT

World journal of … 2005 80 sitasi

Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. RCT

Alimentary pharmacology & … 2005 50 sitasi

Immunonutrition. Review

Current opinion in … 2005 22 sitasi

Pharmacological nutrition in inflammatory bowel diseases. Other

Nutricion hospitalaria 2003

Omega-3 fatty acids in inflammation and autoimmune diseases. Review

Journal of the … 2002 2016 sitasi

Enteral feeding. Other

Current opinion in … 2002 1 sitasi

Enteral feeding. Review

Current opinion in … 2002

[Enteral nutrition in acute Crohn disease]. Review

Zeitschrift fur Gastroenterologie 1998 18 sitasi

Omega-3 fatty acids and low carbohydrate diet for maintenance of remission in Crohn's disease. A randomized controlled multicenter trial. Study … RCT

Scandinavian journal of … 1996 195 sitasi

[Biological activity of fish oil]. Review

Arquivos de gastroenterologia 1996

Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Other

Gut 1990 192 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 1,000-2,000 mg combined EPA/DHA per day
ibdsupport:: 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)

Batas atas: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
50, 100, and 200 mg/kg oral	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Neutral	--
None	--	Neutral	--
95%	--	Mixed	--
None	--	Mixed	12194
None	--	Mixed	--

Waktu terbaik diminum: With meals containing fat for better absorption

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Fishy aftertaste and burping
⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
⚠ Potential increased bleeding time at very high doses (>3 g/day)
⚠ May lower blood pressure slightly

Interaksi yang Diketahui

● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (may reduce omega-3 absorption)
● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)

Asupan atas yang dapat ditoleransi: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Omega-3 Fatty Acids (EPA/DHA) help with Crohn's Disease?

Based on 6 studies with 800 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Crohn's Disease management. Our evidence grade is C (Some Evidence).

How much Omega-3 Fatty Acids (EPA/DHA) should I take for Crohn's Disease?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?

Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Crohn's Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.

Related Evidence

Bahan lain untuk Crohn's Disease

L-Glutamine C Curcumin C Butyrate (Sodium/Calcium Butyrate) C

Omega-3 Fatty Acids (EPA/DHA) untuk kondisi lain

Ulcerative Colitis (UC) C

Kesimpulan Singkat

EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (4)Meta (4)Other (0)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Crohn's Disease

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.