Omega-3 Fatty Acids (EPA/DHA) untuk Crohn's Disease
C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
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C
Kesimpulan
EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
Key Study Findings
Other
Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. …
Dose: 50, 100, and 200 mg/kg oral
vs: Dexamethasone 2.4 mg/kg; DNBS colitis model vs healthy
Outcome: Colonic inflammation markers (MPO, NO, MDA, CAT, GSH)
Efek: None
None
Populasi: DNBS-induced Crohn's disease BALB/c mouse model
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
vs: None
Outcome: IBD microbiota modulation and immune regulation
Efek: None
None
Populasi: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
Efek: None
None
Populasi: Vegan athletes (narrative review)
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Diet-genetics interaction in IBD
Efek: None
None
Populasi: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
Efek: None
None
Populasi: Crohn's disease patients
Observational Study
Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: …
Dose: 95%
vs: None
Outcome: inflammation markers
Efek: None
None
Populasi: None
Key Statistics
6
Studi
800
Peserta
↔
Mixed
C
Peringkat
Referenced Papers
Semergen
2025
4 sitasi
Current nutrition reports
2025
3 sitasi
Journal of ethnopharmacology
2025
1 sitasi
Autoimmunity reviews
2024
12 sitasi
World journal of …
2024
Metabolites
2023
13 sitasi
Scientific reports
2020
56 sitasi
Gastroenterology clinics of …
2018
67 sitasi
International journal of …
2017
143 sitasi
Medical principles and …
2017
45 sitasi
Ugeskrift for laeger
2017
European journal of …
2016
79 sitasi
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 sitasi
Clinics in dermatology
2016
19 sitasi
The Cochrane database …
2014
88 sitasi
Alimentary pharmacology & …
2013
128 sitasi
The British journal …
2012
145 sitasi
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 sitasi
World journal of …
2012
113 sitasi
Frontline gastroenterology
2012
20 sitasi
Pediatrics in review
2012
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
The American journal …
2011
946 sitasi
Inflammatory bowel diseases
2011
195 sitasi
Nutrition in clinical …
2011
1 sitasi
The Cochrane database …
2009
198 sitasi
Review article: the evidence base for interventions used to maintain remission in Crohn's disease.
Review
Alimentary pharmacology & …
2008
50 sitasi
The American journal …
2007
310 sitasi
Digestion
2007
15 sitasi
The Cochrane database …
2007
2 sitasi
Gastroenterology nursing : …
2006
24 sitasi
World journal of …
2005
80 sitasi
Alimentary pharmacology & …
2005
50 sitasi
Immunonutrition.
Review
Current opinion in …
2005
22 sitasi
Nutricion hospitalaria
2003
Journal of the …
2002
2016 sitasi
Enteral feeding.
Other
Current opinion in …
2002
1 sitasi
Enteral feeding.
Review
Current opinion in …
2002
Zeitschrift fur Gastroenterologie
1998
18 sitasi
Scandinavian journal of …
1996
195 sitasi
Arquivos de gastroenterologia
1996
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
Batas atas: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| 50, 100, and 200 mg/kg oral | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| None | -- | Mixed | 12194 |
| None | -- | Mixed | -- |
Waktu terbaik diminum: With meals containing fat for better absorption
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
Interaksi yang Diketahui
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
Asupan atas yang dapat ditoleransi: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Crohn's Disease?
Based on 6 studies with 800 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.
Related Evidence
Bahan lain untuk Crohn's Disease
Omega-3 Fatty Acids (EPA/DHA) untuk kondisi lain
References
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