Omega-3 Fatty Acids (EPA/DHA) 관련 Crohn's Disease
CEPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
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C
결론
EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
Key Study Findings
Other
Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. …
Dose: 50, 100, and 200 mg/kg oral
vs: Dexamethasone 2.4 mg/kg; DNBS colitis model vs healthy
Outcome: Colonic inflammation markers (MPO, NO, MDA, CAT, GSH)
효과: None
None
대상 집단: DNBS-induced Crohn's disease BALB/c mouse model
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
vs: None
Outcome: IBD microbiota modulation and immune regulation
효과: None
None
대상 집단: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
효과: None
None
대상 집단: Vegan athletes (narrative review)
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Diet-genetics interaction in IBD
효과: None
None
대상 집단: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
효과: None
None
대상 집단: Crohn's disease patients
Observational Study
Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: …
Dose: 95%
vs: None
Outcome: inflammation markers
효과: None
None
대상 집단: None
Key Statistics
6
연구
800
참여자
↔
Mixed
C
등급
Referenced Papers
Semergen
2025
4 인용
Current nutrition reports
2025
3 인용
Journal of ethnopharmacology
2025
1 인용
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12 인용
World journal of …
2024
Metabolites
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13 인용
Scientific reports
2020
56 인용
Gastroenterology clinics of …
2018
67 인용
International journal of …
2017
143 인용
Medical principles and …
2017
45 인용
Ugeskrift for laeger
2017
European journal of …
2016
79 인용
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 인용
Clinics in dermatology
2016
19 인용
The Cochrane database …
2014
88 인용
Alimentary pharmacology & …
2013
128 인용
The British journal …
2012
145 인용
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 인용
World journal of …
2012
113 인용
Frontline gastroenterology
2012
20 인용
Pediatrics in review
2012
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
The American journal …
2011
946 인용
Inflammatory bowel diseases
2011
195 인용
Nutrition in clinical …
2011
1 인용
The Cochrane database …
2009
198 인용
Review article: the evidence base for interventions used to maintain remission in Crohn's disease.
Review
Alimentary pharmacology & …
2008
50 인용
The American journal …
2007
310 인용
Digestion
2007
15 인용
The Cochrane database …
2007
2 인용
Gastroenterology nursing : …
2006
24 인용
World journal of …
2005
80 인용
Alimentary pharmacology & …
2005
50 인용
Immunonutrition.
Review
Current opinion in …
2005
22 인용
Nutricion hospitalaria
2003
Journal of the …
2002
2016 인용
Enteral feeding.
Other
Current opinion in …
2002
1 인용
Enteral feeding.
Review
Current opinion in …
2002
Zeitschrift fur Gastroenterologie
1998
18 인용
Scandinavian journal of …
1996
195 인용
Arquivos de gastroenterologia
1996
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
상한량: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| 50, 100, and 200 mg/kg oral | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| None | -- | Mixed | 12194 |
| None | -- | Mixed | -- |
권장 복용 시간: With meals containing fat for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
알려진 상호작용
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
일일 최대 섭취 허용량: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Crohn's Disease?
Based on 6 studies with 800 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.
Related Evidence
관련 다른 성분: Crohn's Disease
Omega-3 Fatty Acids (EPA/DHA) 다른 건강 상태에 대한 근거
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.