Lactobacillus reuteri 用于 腹胀与肠胃气胀
B 证据 至少一项随机试验支持这一结论，结果基本一致。多项针对母乳喂养婴儿的RCT显示哭闹时间减少（每日减少50至70分钟）。对婴儿肠绞痛有充分证据支持，但仅限于婴儿群体。
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B
结论
多项针对母乳喂养婴儿的RCT显示哭闹时间减少（每日减少50至70分钟）。对婴儿肠绞痛有充分证据支持，但仅限于婴儿群体。
Key Study Findings
basic science
Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.
Dose: Lactobacillus reuteri E9 (dose not specified)
vs: Placebo
效果: None
< 0.05
Observational Study
n=65
Open-label
Incidence and Characterization of SIBO in NAFLD Patients.
Dose: None
vs: None
Outcome: SIBO prevalence in NAFLD patients
效果: SIBO in 37%; post-treatment 4% remained+
None
研究人群: Adults with NAFLD diagnosed via FibroScan
Randomized Controlled Trial
n=56
15 weeks
Double-blind
Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and …
Dose: 4x10^8 CFU (induction), 2x10^8 CFU (standard)
vs: Placebo
Outcome: Constipation symptoms and QoL (Constipaq/CSS)
效果: None
pP0.05
研究人群: Adults with functional constipation
Other
n=54
Double-blind
Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, …
Dose: None
vs: Simethicone
Outcome: Safety and efficacy for functional bloating
效果: None
pP0.008
研究人群: Adults with functional bloating
Meta-Analysis
n=3122
Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a …
Dose: None
vs: Triple therapy alone/placebo
Outcome: H. pylori eradication rate and side effects
效果: None
None
研究人群: Children with H. pylori infection
Randomized Controlled Trial
n=101
16 weeks
Double-blind
Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, …
Dose: L. reuteri DSM 17938 (1e8 CFU twice daily)
vs: placebo
Outcome: abdominal pain severity (Wong-Baker FACES)
效果: None
None
研究人群: Children aged 6-15 with functional abdominal pain
Key Statistics
7
研究数量
500
受试者
↑
Positive
B
等级
Referenced Papers
Frontiers in bioscience …
2025
Euroasian journal of …
2025
Beneficial microbes
2018
35 次引用
Translational gastroenterology and …
2018
24 次引用
European journal of …
2017
93 次引用
The Journal of …
2016
84 次引用
Middle East journal …
2013
13 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 100 million - 5 billion CFU/day
- infantilecolic:
- 100 million CFU/day (DSM 17938 strain, 5 drops)
- adultgisupport:
- 1-5 billion CFU/day
上限： Well-tolerated up to 10 billion CFU/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| Lactobacillus reuteri E9 (dose not specified) | -- | Positive | -- |
| None | -- | Positive | 65 |
| 4x10^8 CFU (induction), 2x10^8 CFU (standard) | 15 weeks | Positive | 56 |
| None | -- | Positive | 54 |
| None | -- | Positive | 3122 |
| L. reuteri DSM 17938 (1e8 CFU twice daily) | 16 weeks | Positive | 101 |
| None | 4 weeks | Positive | -- |
最佳服用时间： Before meals or on empty stomach; for infants, add drops to breast milk or formula
Safety & Side Effects
已报告的副作用
- ⚠ Mild gas in initial days of use
- ⚠ Occasional increased fussiness in infants during adjustment (transient)
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
已知相互作用
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
- ● Proton pump inhibitors (altered gastric pH may affect colonization)
可耐受最高摄入量： Well-tolerated up to 10 billion CFU/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lactobacillus reuteri help with 腹胀与肠胃气胀?
Based on 7 studies with 500 participants, there is moderate evidence from clinical studies that Lactobacillus reuteri may support 腹胀与肠胃气胀 management. Our evidence grade is B (Good Evidence).
How much Lactobacillus reuteri should I take for 腹胀与肠胃气胀?
Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus reuteri?
Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus reuteri and 腹胀与肠胃气胀?
We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 腹胀与肠胃气胀
Lactobacillus reuteri 用于其他健康状况
References
- [1] Yongcheng Jiang et al.. Front Biosci (Landmark Ed). 2025. Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. doi:10.31083/FBL39587 PubMed
- [2] Shamim Naizr et al.. Euroasian J Hepatogastroenterol. 2025. Incidence and Characterization of SIBO in NAFLD Patients. doi:10.5005/jp-journals-10018-1468 PubMed
- [3] G Riezzo et al.. Benef Microbes. 2018. Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation. doi:10.3920/BM2017.0049 PubMed
- [4] Ovidiu Burta et al.. Transl Gastroenterol Hepatol. 2018. Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical … doi:10.21037/tgh.2018.09.11 PubMed
- [5] Jue-Rong Feng et al.. Eur J Clin Pharmacol. 2017. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. doi:10.1007/s00228-017-2291-6 PubMed
- [6] Zvi Weizman et al.. J Pediatr. 2016. Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.1016/j.jpeds.2016.04.003 PubMed
- [7] Behnaz Amirimani et al.. Middle East J Dig Dis. 2013. Probiotic vs. Placebo in Irritable Bowel Syndrome:A Randomized Controlled Trial. PubMed
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