Lactobacillus reuteri for Bloating and Intestinal Gas

Q: Does Lactobacillus reuteri help with Bloating and Intestinal Gas?

Based on 7 studies with 500 participants, there is moderate evidence from clinical studies that Lactobacillus reuteri may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).

Q: How much Lactobacillus reuteri should I take for Bloating and Intestinal Gas?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus reuteri and Bloating and Intestinal Gas?

We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

Multiple RCTs in breastfed infants show reduced crying time (50-70 min/day reduction). Well-established evidence for infantile colic but limited to infant population.

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The Bottom Line

Multiple RCTs in breastfed infants show reduced crying time (50-70 min/day reduction). Well-established evidence for infantile colic but limited to infant population.

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Effect: None < 0.05

Observational Study n=65 Open-label

Incidence and Characterization of SIBO in NAFLD Patients.

Dose: None vs: None Outcome: SIBO prevalence in NAFLD patients Effect: SIBO in 37%; post-treatment 4% remained+ None

Population: Adults with NAFLD diagnosed via FibroScan

Randomized Controlled Trial n=56 15 weeks Double-blind

Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and …

Dose: 4x10^8 CFU (induction), 2x10^8 CFU (standard) vs: Placebo Outcome: Constipation symptoms and QoL (Constipaq/CSS) Effect: None pP0.05

Population: Adults with functional constipation

Other n=54 Double-blind

Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, …

Dose: None vs: Simethicone Outcome: Safety and efficacy for functional bloating Effect: None pP0.008

Population: Adults with functional bloating

Meta-Analysis n=3122

Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a …

Dose: None vs: Triple therapy alone/placebo Outcome: H. pylori eradication rate and side effects Effect: None None

Population: Children with H. pylori infection

Randomized Controlled Trial n=101 16 weeks Double-blind

Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, …

Dose: L. reuteri DSM 17938 (1e8 CFU twice daily) vs: placebo Outcome: abdominal pain severity (Wong-Baker FACES) Effect: None None

Population: Children aged 6-15 with functional abdominal pain

Key Statistics

Studies

500

Participants

↑

Positive

Grade

Referenced Papers

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Incidence and Characterization of SIBO in NAFLD Patients. Other

Euroasian journal of … 2025

Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation. RCT

Beneficial microbes 2018 35 citations

Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical … Other

Translational gastroenterology and … 2018 24 citations

Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Meta-Analysis

European journal of … 2017 93 citations

Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, Double-Blind, Placebo-Controlled Trial. RCT

The Journal of … 2016 84 citations

Probiotic vs. Placebo in Irritable Bowel Syndrome:A Randomized Controlled Trial. Other

Middle East journal … 2013 13 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:: 100 million - 5 billion CFU/day
infantilecolic:: 100 million CFU/day (DSM 17938 strain, 5 drops)
adultgisupport:: 1-5 billion CFU/day

Upper limit: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosages Studied in Research

Dosage	Duration	Effect	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
None	--	Positive	65
4x10^8 CFU (induction), 2x10^8 CFU (standard)	15 weeks	Positive	56
None	--	Positive	54
None	--	Positive	3122
L. reuteri DSM 17938 (1e8 CFU twice daily)	16 weeks	Positive	101
None	4 weeks	Positive	--

Best taken: Before meals or on empty stomach; for infants, add drops to breast milk or formula

Safety & Side Effects

Reported Side Effects

⚠ Mild gas in initial days of use
⚠ Occasional increased fussiness in infants during adjustment (transient)
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Known Interactions

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Proton pump inhibitors (altered gastric pH may affect colonization)

Tolerable upper intake: Well-tolerated up to 10 billion CFU/day in clinical trials

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Lactobacillus reuteri help with Bloating and Intestinal Gas?

Based on 7 studies with 500 participants, there is moderate evidence from clinical studies that Lactobacillus reuteri may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).

How much Lactobacillus reuteri should I take for Bloating and Intestinal Gas?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus reuteri and Bloating and Intestinal Gas?

We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Other ingredients for Bloating and Intestinal Gas

Pancreatic Enzymes (Pancrelipase) A Ginger B Alpha-Galactosidase B Medium-Chain Triglycerides (MCT Oil) C

Lactobacillus reuteri for other conditions

Gastroesophageal Reflux Disease (GERD) C

Quick Verdict

Multiple RCTs in breastfed infants show reduced crying time (50-70 min/day reduction). Well-established evidence for infantile colic but limited to infant population.

Evidence Strength72%

High confidence

Study Breakdown

RCT (2)Meta (1)Other (4)

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References

[1] Yongcheng Jiang et al.. Front Biosci (Landmark Ed). 2025. Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. doi:10.31083/FBL39587 PubMed
[2] Shamim Naizr et al.. Euroasian J Hepatogastroenterol. 2025. Incidence and Characterization of SIBO in NAFLD Patients. doi:10.5005/jp-journals-10018-1468 PubMed
[3] G Riezzo et al.. Benef Microbes. 2018. Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation. doi:10.3920/BM2017.0049 PubMed
[4] Ovidiu Burta et al.. Transl Gastroenterol Hepatol. 2018. Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical … doi:10.21037/tgh.2018.09.11 PubMed
[5] Jue-Rong Feng et al.. Eur J Clin Pharmacol. 2017. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. doi:10.1007/s00228-017-2291-6 PubMed
[6] Zvi Weizman et al.. J Pediatr. 2016. Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.1016/j.jpeds.2016.04.003 PubMed
[7] Behnaz Amirimani et al.. Middle East J Dig Dis. 2013. Probiotic vs. Placebo in Irritable Bowel Syndrome:A Randomized Controlled Trial. PubMed

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.

Lactobacillus reuteri for Bloating and Intestinal Gas

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The Bottom Line

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Commonly Used Dosages

Dosages Studied in Research

Safety & Side Effects

Reported Side Effects

Known Interactions

Frequently Asked Questions

Related Evidence

Other ingredients for Bloating and Intestinal Gas

Lactobacillus reuteri for other conditions

References