Lactobacillus reuteri 用于 Gastroesophageal Reflux Disease (GERD)

Q: Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

Q: How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

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结论

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo 效果: None < 0.05

Review

The evidence for probiotics in the treatment of digestive disorders in the pediatric population.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Pediatric population

Key Statistics

研究数量

250

受试者

↑

Positive

等级

Referenced Papers

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 次引用

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 100 million - 5 billion CFU/day
infantilecolic:: 100 million CFU/day (DSM 17938 strain, 5 drops)
adultgisupport:: 1-5 billion CFU/day

上限： Well-tolerated up to 10 billion CFU/day in clinical trials

研究中使用的剂量

剂量	持续时间	效果	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
None	--	Mixed	--

最佳服用时间： Before meals or on empty stomach; for infants, add drops to breast milk or formula

Safety & Side Effects

已报告的副作用

⚠ Mild gas in initial days of use
⚠ Occasional increased fussiness in infants during adjustment (transient)
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

已知相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Proton pump inhibitors (altered gastric pH may affect colonization)

可耐受最高摄入量： Well-tolerated up to 10 billion CFU/day in clinical trials

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Gastroesophageal Reflux Disease (GERD)

Lactobacillus gasseri D Ginger D Slippery Elm D

Lactobacillus reuteri 用于其他健康状况

Bloating and Intestinal Gas B

快速结论

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Evidence Strength52%

Moderate confidence

研究分析

RCT (0)Meta (0)Other (2)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Gastroesophageal Reflux Disease (GERD)

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