Butyrate (Sodium/Calcium Butyrate) for Ulcerative Colitis (UC)

References

1. [1] Sonia Facchin et al.. Dig Liver Dis. 2026. Impact of oral butyrate on clinical and biochemical parameters in IBD: A randomized placebo-controlled study targeting gut microbiota. doi:10.1016/j.dld.2025.11.014 PubMed
2. [2] Zhe Song et al.. Phytomedicine. 2025. Sea buckthorn berries alleviate ulcerative colitis via regulating gut Faecalibaculum rodentium-mediated butyrate biosynthesis. doi:10.1016/j.phymed.2025.156490 PubMed
3. [3] Haifan Liu et al.. Phytomedicine. 2025. Sishen Pill & Tongxieyaofang ameliorated ulcerative colitis through the activation of HIF-1α acetylation by gut microbiota-derived propionate and butyrate. doi:10.1016/j.phymed.2024.156264 PubMed
4. [4] Yingyin Liu et al.. Ann Med. 2025. Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora. doi:10.1080/07853890.2025.2470958 PubMed
5. [5] Yunqi Xing et al.. Imeta. 2025. Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation. doi:10.1002/imt2.70040 PubMed
6. [6] Donya Firoozi et al.. J Nutr Metab. 2025. Effects of Short Chain Fatty Acid-Butyrate Supplementation on the Disease Severity, Inflammation, and Psychological Factors in Patients With Active Ulcerative … doi:10.1155/jnme/3165876 PubMed
7. [7] Miao Liu et al.. Mol Med. 2025. Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro. doi:10.1186/s10020-025-01096-7 PubMed
8. [8] Jinfeng Guo et al.. Nutrients. 2025. Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota. doi:10.3390/nu17071272 PubMed
9. [9] Gerard Serrano-Gómez et al.. Biomark Res. 2025. Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology. doi:10.1186/s40364-025-00802-1 PubMed
10. [10] Xinyu Shao et al.. J Proteome Res. 2025. Microbial Butyrate Modified by Melatonin Alleviates Colon Inflammation by Inhibiting GPR109A/Caspase-1-Dependent Macrophage M1 Polarization. doi:10.1021/acs.jproteome.4c00915 PubMed
11. [11] Nannapat Sangfuang et al.. Transl Res. 2025. Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's disease: A pilot study. doi:10.1016/j.trsl.2025.02.004 PubMed
12. [12] Haifan Liu et al.. Phytomedicine. 2025. Angelicin ameliorated ulcerative colitis through activating HDAC1-derived HIF-1α acetylation. doi:10.1016/j.phymed.2025.156546 PubMed
13. [13] Tangjuan Liu et al.. Front Cell Infect Microbiol. 2025. Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs. doi:10.3389/fcimb.2025.1628488 PubMed
14. [14] Devansh Shah et al.. Langenbecks Arch Surg. 2025. Is the microbiome the answer to inflammatory bowel disease: systematic review. doi:10.1007/s00423-025-03897-0 PubMed
15. [15] Sinan Xiao et al.. Mediators Inflamm. 2025. Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization. doi:10.1155/mi/1675577 PubMed
16. [16] Maria Kulecka et al.. Nat Commun. 2025. Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis. doi:10.1038/s41467-025-62533-z PubMed
17. [17] Yongcheng Jiang et al.. Front Biosci (Landmark Ed). 2025. Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. doi:10.31083/FBL39587 PubMed
18. [18] Ruifang Li et al.. PLoS One. 2025. Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through … doi:10.1371/journal.pone.0337214 PubMed
19. [19] Hangping Chen et al.. Biochim Biophys Acta Mol Basis Dis. 2024. Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier. doi:10.1016/j.bbadis.2023.166984 PubMed
20. [20] Xi Fan et al.. ACS Nano. 2024. An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease. doi:10.1021/acsnano.3c05732 PubMed
21. [21] Donya Firoozi et al.. Lipids Health Dis. 2024. Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative … doi:10.1186/s12944-024-02203-z PubMed
22. [22] Wenying Li et al.. ACS Nano. 2024. Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4-Octyl-Itaconate. doi:10.1021/acsnano.4c01520 PubMed
23. [23] Kaixin Peng et al.. J Agric Food Chem. 2024. Butyrate Inhibits the HDAC8/NF-κB Pathway to Enhance Slc26a3 Expression and Improve the Intestinal Epithelial Barrier to Relieve Colitis. doi:10.1021/acs.jafc.4c04456 PubMed
24. [24] Achuthan Ambat et al.. Gut Microbes. 2024. Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing … doi:10.1080/19490976.2024.2382324 PubMed
25. [25] Chen Wang et al.. Microbiol Res. 2024. Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review. doi:10.1016/j.micres.2024.127660 PubMed
26. [26] Benyue Sun et al.. J Agric Food Chem. 2024. Litchi Procyanidins Ameliorate DSS-Induced Colitis through Gut Microbiota-Dependent Regulation of Treg/Th17 Balance. doi:10.1021/acs.jafc.4c05577 PubMed
27. [27] Ningning He et al.. J Agric Food Chem. 2024. Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway. doi:10.1021/acs.jafc.4c01387 PubMed
28. [28] Jonas Poppe et al.. Gut Microbes. 2024. Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an in vitro analysis. doi:10.1080/19490976.2024.2424913 PubMed
29. [29] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
30. [30] Beiying Deng et al.. Sci Rep. 2024. Exploring the butyrate metabolism-related shared genes in metabolic associated steatohepatitis and ulcerative colitis. doi:10.1038/s41598-024-66574-0 PubMed
31. [31] Tianying Tan et al.. Front Pharmacol. 2024. Zhili decoction ameliorates ulcerative colitis by modulating gut microbiota and related metabolite, and inhibiting the TLR4/NF-κB/NLRP3 pathway. doi:10.3389/fphar.2024.1481273 PubMed
32. [32] Nadia Musco et al.. J Anim Sci. 2024. Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system. doi:10.1093/jas/skae376 PubMed
33. [33] Neeraja Recharla et al.. Nutrients. 2023. Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review. doi:10.3390/nu15102275 PubMed
34. [34] Susanna Meade et al.. Gut Microbes. 2023. Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review. doi:10.1080/19490976.2023.2287073 PubMed
35. [35] Marcos A F Caetano et al.. Cells. 2023. Butyrate Protects Myenteric Neurons Loss in Mice Following Experimental Ulcerative Colitis. doi:10.3390/cells12131672 PubMed
36. [36] Alexandre Kleber Silveira et al.. Immunol Invest. 2023. Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. doi:10.1080/08820139.2023.2244967 PubMed
37. [37] Giuseppina Mandalari et al.. Nutrients. 2023. Effect of Nuts on Gastrointestinal Health. doi:10.3390/nu15071733 PubMed
38. [38] Hauke Christian Tews et al.. Lipids Health Dis. 2023. Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis … doi:10.1186/s12944-023-01929-6 PubMed
39. [39] Xiaoxia Liu et al.. J Agric Food Chem. 2022. Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism. doi:10.1021/acs.jafc.2c06417 PubMed
40. [40] Liping Liang et al.. Clin Sci (Lond). 2022. Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. doi:10.1042/CS20210778 PubMed
41. [41] Lingyan Ma et al.. Microbiol Spectr. 2022. Clostridium butyricum and Its Derived Extracellular Vesicles Modulate Gut Homeostasis and Ameliorate Acute Experimental Colitis. doi:10.1128/spectrum.01368-22 PubMed
42. [42] Ali Nabavi-Rad et al.. Gut Microbes. 2022. The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management. doi:10.1080/19490976.2022.2108655 PubMed
43. [43] Siying Zhu et al.. Front Cell Infect Microbiol. 2022. Composition and diverse differences of intestinal microbiota in ulcerative colitis patients. doi:10.3389/fcimb.2022.953962 PubMed
44. [44] Hana Čipčić Paljetak et al.. Gut Microbes. 2022. Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients. doi:10.1080/19490976.2022.2083419 PubMed
45. [45] Anna Pietrzak et al.. Nutrients. 2022. Sodium Butyrate Effectiveness in Children and Adolescents with Newly Diagnosed Inflammatory Bowel Diseases-Randomized Placebo-Controlled Multicenter Trial. doi:10.3390/nu14163283 PubMed
46. [46] Weimin Dong et al.. Front Cell Infect Microbiol. 2022. Sodium butyrate treatment and fecal microbiota transplantation provide relief from ulcerative colitis-induced prostate enlargement. doi:10.3389/fcimb.2022.1037279 PubMed
47. [47] Stefan Satka et al.. Int J Mol Sci. 2022. Effect of DSS-Induced Ulcerative Colitis and Butyrate on the Cytochrome P450 2A5: Contribution of the Microbiome. doi:10.3390/ijms231911627 PubMed
48. [48] Sonia Facchin et al.. Neurogastroenterol Motil. 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. doi:10.1111/nmo.13914 PubMed
49. [49] Daniela Parada Venegas et al.. Front Immunol. 2019. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. doi:10.3389/fimmu.2019.00277 PubMed
50. [50] N A Danilova et al.. Ter Arkh. 2019. Markers of dysbiosis in patients with ulcerative colitis and Crohn's disease. doi:10.26442/00403660.2019.04.000211 PubMed
51. [51] Hilda Vargas-Robles et al.. World J Gastroenterol. 2019. Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo. doi:10.3748/wjg.v25.i30.4181 PubMed
52. [52] Zhao-Hua Shen et al.. World J Gastroenterol. 2018. Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation. doi:10.3748/wjg.v24.i1.5 PubMed
53. [53] João P B Silva et al.. Curr Pharm Des. 2018. Protective Mechanisms of Butyrate on Inflammatory Bowel Disease. doi:10.2174/1381612824666181001153605 PubMed
54. [54] Emilio J Laserna-Mendieta et al.. J Crohns Colitis. 2018. Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis. doi:10.1093/ecco-jcc/jjx137 PubMed
55. [55] Zora Váradyová et al.. J Anim Physiol Anim Nutr (Berl). 2018. Modulation of ruminal and intestinal fermentation by medicinal plants and zinc from different sources. doi:10.1111/jpn.12940 PubMed
56. [56] Ashwin N Ananthakrishnan et al.. Cell Host Microbe. 2017. Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases. doi:10.1016/j.chom.2017.04.010 PubMed
57. [57] Sathish Sivaprakasam et al.. Compr Physiol. 2017. Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis. doi:10.1002/cphy.c170014 PubMed
58. [58] Saurabh Kedia et al.. J Gastroenterol. 2016. Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India. doi:10.1007/s00535-016-1193-1 PubMed
59. [59] Pamela V Chang et al.. Proc Natl Acad Sci U S A. 2014. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. doi:10.1073/pnas.1322269111 PubMed
60. [60] Kathleen Machiels et al.. Gut. 2014. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. doi:10.1136/gutjnl-2013-304833 PubMed
61. [61] Ping Wan et al.. World J Gastroenterol. 2014. Advances in treatment of ulcerative colitis with herbs: from bench to bedside. doi:10.3748/wjg.v20.i39.14099 PubMed
62. [62] Venessa Eeckhaut et al.. Gut. 2013. Butyricicoccus pullicaecorum in inflammatory bowel disease. doi:10.1136/gutjnl-2012-303611 PubMed
63. [63] Henrike M Hamer et al.. Clin Nutr. 2010. Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission. doi:10.1016/j.clnu.2010.04.002 PubMed
64. [64] Cyril W C Kendall et al.. J AOAC Int. 2004. Resistant starches and health. PubMed
65. [65] D J Jenkins et al.. Curr Opin Gastroenterol. 2000. Resistant starches. doi:10.1097/00001574-200003000-00014 PubMed
66. [66] M M Duffy et al.. Dis Colon Rectum. 1998. Mucosal metabolism in ulcerative colitis and Crohn's disease. doi:10.1007/BF02237056 PubMed
67. [67] W E Roediger et al.. Dig Dis Sci. 1997. Colonic sulfide in pathogenesis and treatment of ulcerative colitis. doi:10.1023/a:1018851723920 PubMed
68. [68] A Burke et al.. Baillieres Clin Gastroenterol. 1997. Nutrition and ulcerative colitis. doi:10.1016/s0950-3528(97)90059-2 PubMed
69. [69] H Hove et al.. Dis Colon Rectum. 1995. Butyrate absorption and lactate secretion in ulcerative colitis. doi:10.1007/BF02148853 PubMed
70. [70] W Frankel et al.. J Surg Res. 1994. Butyrate increases colonocyte protein synthesis in ulcerative colitis. doi:10.1006/jsre.1994.1133 PubMed