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Butyrate (Sodium/Calcium Butyrate)
Butyrate (Sodium/Calcium Butyrate)

fatty_acid

别名: Sodium Butyrate, Calcium Butyrate, Butyric Acid, Tributyrin, ButyrEn

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About





            

                
丁酸盐是一种短链脂肪酸（SCFA），是结肠细胞的主要能量来源，可提供其所需能量的约70%。它可能有助于抑制NF-κB信号通路以支持结肠健康的炎症反应，通过组蛋白去乙酰化酶（HDAC）抑制作用促进调节性T细胞分化，并增强紧密连接的组装及黏液层厚度。研究表明，口服丁酸盐补充剂可能有助于支持肠道健康及炎症性肠道状况的症状管理。丁酸钠和丁酸钙是常见的补充形式。

            

        

        

        
        
        

            

  
How It Works





            

                
Primary energy source for colonocytes providing approximately 70% of cellular energy; inhibits NF-kB transcription factor reducing colonic inflammation; promotes regulatory T cell differentiation via HDAC inhibition; enhances tight junction assembly (claudin-1, ZO-1) and stimulates mucus layer thickness; activates GPR109A (HCAR2) anti-inflammatory signaling.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Ulcerative Colitis (UC)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    390
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Crohn's Disease
                                    
                                
                                
                                    C

                                
                                
                                    2
                                
                                
                                    200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Unpleasant taste/odor (butyric acid has a strong rancid butter smell)
                
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                    Mild GI discomfort (nausea, bloating)
                
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                    Belching with butyric acid odor
                
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                    Enteric-coated formulations reduce taste issues
                
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Drug & Supplement Interactions





            
    
                
                
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                    5-ASA medications (mesalamine) — additive anti-inflammatory effect (potentially beneficial in IBD)
                
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  • 
                    
                    No significant adverse drug interactions known
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Omega-3 Fatty Acids (EPA/DHA)
                    
                
                
                
                    Medium-Chain Triglycerides (MCT Oil)
                    
                
                
            

        

        
    


    
    












    

        FDA 免责声明:
        这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。