Bacillus coagulans 用于 Irritable Bowel Syndrome (IBS)
BReduces abdominal pain, bloating, and diarrhea in IBS. Spore-forming nature provides excellent stability and gastric acid survival.
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B
结论
Reduces abdominal pain, bloating, and diarrhea in IBS. Spore-forming nature provides excellent stability and gastric acid survival.
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
效果: None
None
研究人群: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
n=61
4 weeks
Double-blind
Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal …
Dose: None
vs: Placebo
Outcome: Abdominal pain (NRS) and stool consistency (BSFS)
效果: None
P = 0.003 (pain); P = 0.035 (s
研究人群: Adults with diarrhoea-predominant IBS (IBS-D)
Randomized Controlled Trial
n=100
12 weeks
Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, …
Dose: None
vs: Control
Outcome: Pain outcomes
效果: None
P < .001
研究人群: IBS patients
Meta-Analysis
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review …
Dose: Various probiotic strains/mixtures
vs: Placebo
Outcome: Outcome-specific efficacy ranking in IBS
效果: None
None
研究人群: Adults with IBS (RCTs)
Randomized Controlled Trial
12 weeks
Double-blind
The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in …
Dose: 20.5%
vs: placebo
Outcome: IBS symptom improvement
效果: None
p = 0.038
研究人群: Adults with IBS
Review
Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives.
Dose: None
vs: None
Outcome: colitis/IBD severity
效果: None
None
研究人群: None
Key Statistics
3
研究数量
400
受试者
↑
Positive
B
等级
Referenced Papers
Journal of clinical …
2026
Beneficial microbes
2026
Medicine
2024
6 次引用
Nutrients
2023
33 次引用
Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives.
Review
Journal of oral …
2023
12 次引用
International journal of …
2023
9 次引用
Journal of clinical …
2023
9 次引用
Medicine
2021
45 次引用
Journal of dietary …
2021
33 次引用
European journal of …
2020
20 次引用
Scientific reports
2019
65 次引用
Beneficial microbes
2019
45 次引用
Beneficial microbes
2019
29 次引用
Food & nutrition …
2018
162 次引用
Beneficial microbes
2018
59 次引用
Nutrition journal
2016
102 次引用
European review for …
2014
33 次引用
Gastroenterology and hepatology …
2014
Postgraduate medicine
2009
144 次引用
Methods and findings …
2009
104 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 1-2 billion CFU/day
- ibssupport:
- 2 billion CFU/day (GBI-30 6086 strain)
上限： Well-tolerated up to 6 billion CFU/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 4 weeks | Positive | 61 |
| None | 12 weeks | Positive | 100 |
| Various probiotic strains/mixtures | -- | Positive | -- |
| 20.5% | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals for optimal spore germination and colonization
Safety & Side Effects
已报告的副作用
- ⚠ Mild gas during initial use (generally less than other probiotics due to spore form)
- ⚠ Occasional bloating
- ⚠ Rare loose stools
已知相互作用
- ● Antibiotics (spore form is more resistant than vegetative probiotics, but spacing still recommended)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
可耐受最高摄入量： Well-tolerated up to 6 billion CFU/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Bacillus coagulans help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is moderate evidence from clinical studies that Bacillus coagulans may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Bacillus coagulans should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 1-2 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bacillus coagulans?
Reported side effects may include Mild gas during initial use (generally less than other probiotics due to spore form), Occasional bloating, Rare loose stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bacillus coagulans and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Irritable Bowel Syndrome (IBS)
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