Bifidobacterium lactis cho Chronic Constipation

Q: Does Bifidobacterium lactis help with Chronic Constipation?

Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).

Q: How much Bifidobacterium lactis should I take for Chronic Constipation?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Bifidobacterium lactis?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

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Kết luận

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

Key Study Findings

Randomized Controlled Trial 8 weeks Double-blind

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …

Dose: None so với: Placebo Outcome: Complete spontaneous bowel movements (CSBMs) Hiệu quả: None None

Đối tượng nghiên cứu: Adults with functional constipation (Rome III)

Randomized Controlled Trial n=67 4 weeks Double-blind

Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …

Dose: None so với: Placebo Outcome: Weekly spontaneous bowel movements Hiệu quả: 4.94 vs 3.00 (P<0.001) P<0.001

Đối tượng nghiên cứu: Older adults >=60 with functional constipation (Rome IV)

Randomized Controlled Trial n=35 12 weeks Double-blind

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …

Dose: None so với: Placebo Outcome: Gut barrier function (zonulin levels) Hiệu quả: Zonulin -19.5 ng/mL at week 16 p=0.0002 wk16; p=0.0053 grp

Đối tượng nghiên cứu: IBS without constipation patients

Review

An update on probiotics in paediatrics.

Dose: None so với: None Outcome: GI disorder outcomes in paediatrics Hiệu quả: None None

Đối tượng nghiên cứu: Paediatric patients with GI disorders

In Vitro n=35

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …

Dose: 1e6 CFU/mL so với: IBS supernatants without probiotic Outcome: Caco-2 paracellular permeability Hiệu quả: None <0.001

Đối tượng nghiên cứu: IBS patients (28) and asymptomatic controls (7)

Randomized Controlled Trial n=128 2 weeks Double-blind

Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.

Dose: 0.5 mL daily for 14 days so với: Placebo Outcome: Fever duration (days) Hiệu quả: RR 0.64 (95% CI 0.51-0.80) None

Đối tượng nghiên cứu: Children 28 days-4 years with fever and URTI

Key Statistics

Nghiên cứu

600

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial. RCT

JAMA network open 2025 13 trích dẫn

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results … RCT

Nutrients 2025 7 trích dẫn

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 Counteracts the Increase … Other

International journal of … 2025 4 trích dẫn

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial. RCT

Molecular nutrition & … 2025 2 trích dẫn

Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, … RCT

The journal of … 2025

An update on probiotics in paediatrics. Other

Current opinion in … 2025

Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial. RCT

JAMA network open 2024 9 trích dẫn

Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention … RCT

European journal of … 2024 9 trích dẫn

Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. RCT

Gut microbes 2023 143 trích dẫn

The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in Adult Patients with Irritable Bowel … Other

Journal of clinical … 2023 9 trích dẫn

Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis

Clinical nutrition (Edinburgh, … 2022 42 trích dẫn

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice. Other

Frontiers in nutrition 2022 24 trích dẫn

In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota. Other

Frontiers in nutrition 2022 22 trích dẫn

Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models. Other

PloS one 2022 21 trích dẫn

The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. RCT

Medicine 2022 14 trích dẫn

Positive effect of Bifidobacterium animalis subsp. lactis VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Other

Frontiers in microbiology 2022 4 trích dẫn

The effect of probiotics on functional constipation in adults: Double-blind, randomized, placebo-controlled study. Other

Medicine 2021 8 trích dẫn

Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Meta-Analysis

Clinical nutrition (Edinburgh, … 2020 94 trích dẫn

A combination of three probiotic strains for treatment of acute diarrhoea in hospitalised children: an open label, randomised controlled trial. RCT

Beneficial microbes 2020 22 trích dẫn

EFFECTS OF SYNBIOTIC SUPPLEMENTATION ON GUT FUNCTIONING AND SYSTEMIC INFLAMMATION OF COMMUNITY-DWELLING ELDERS - SECONDARY ANALYSES FROM A RANDOMIZED CLINICAL … RCT

Arquivos de gastroenterologia 2020 7 trích dẫn

Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in … RCT

Alimentary pharmacology & … 2019 59 trích dẫn

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 trích dẫn

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 trích dẫn

Effects of Synbiotics among Constipated Adults in Serdang, Selangor, Malaysia-A Randomised, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2018 28 trích dẫn

Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. RCT

The Turkish journal … 2017 29 trích dẫn

Safety of a New Synbiotic Starter Formula. Other

Pediatric gastroenterology, hepatology … 2017 27 trích dẫn

Promotility Action of the Probiotic Bifidobacterium lactis HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine. Other

Frontiers in neuroscience 2017 14 trích dẫn

Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Other

Korean journal for … 2017 7 trích dẫn

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. RCT

The Turkish journal … 2016 63 trích dẫn

The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Systematic Review

Paediatric drugs 2015 122 trích dẫn

The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Meta-Analysis

The American journal … 2014 284 trích dẫn

Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. RCT

Nutrition journal 2014 75 trích dẫn

Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials. Meta-Analysis

World journal of … 2013 111 trích dẫn

Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis bi-07) in improving symptoms of constipation. RCT

Arquivos de gastroenterologia 2013 49 trích dẫn

[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. RCT

Georgian medical news 2013

Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis. RCT

World journal of … 2012 55 trích dẫn

Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Other

Nutrition journal 2012 51 trích dẫn

Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. RCT

Scandinavian journal of … 2011 187 trích dẫn

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 trích dẫn

Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. RCT

Pediatrics 2011 101 trích dẫn

Systematic review of randomised controlled trials: probiotics for functional constipation. Systematic Review

World journal of … 2010 276 trích dẫn

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit … RCT

Alimentary pharmacology & … 2009 333 trích dẫn

Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre … RCT

BMC pediatrics 2009 46 trích dẫn

Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. RCT

World journal of … 2008 163 trích dẫn

Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. RCT

The journal of … 2007

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 1-10 billion CFU/day
immunesupport:: 5-10 billion CFU/day
constipationsupport:: 17.2 billion CFU/day (HN019 strain, optimal dose)

Giới hạn trên: Well-tolerated up to 17.2 billion CFU/day in clinical trials

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	8 weeks	Neutral	--
None	4 weeks	Positive	67
None	12 weeks	Positive	35
None	--	Positive	--
1e6 CFU/mL	--	Positive	35
0.5 mL daily for 14 days	2 weeks	Positive	128
None	2 weeks	Negative	117
10 g	4 weeks	Positive	--

Thời điểm dùng tốt nhất: With or without food; morning dosing may be optimal for transit effects

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Mild gas and bloating during initial use
⚠ Occasional abdominal discomfort
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Tương tác đã biết

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

Mức hấp thụ tối đa cho phép: Well-tolerated up to 17.2 billion CFU/day in clinical trials

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Frequently Asked Questions

Does Bifidobacterium lactis help with Chronic Constipation?

Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).

How much Bifidobacterium lactis should I take for Chronic Constipation?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium lactis?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Chronic Constipation

Psyllium Husk A Inulin B Fructooligosaccharides (FOS) C

Đánh giá nhanh

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (25)Meta (4)Other (0)

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