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Bifidobacterium bifidum cho Functional Dyspepsia

C

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

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Kết luận

            
            
B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Controlled Clinical Trial
                
                
                n=54
                
                
                3.0 weeks
                
                
            

            
                [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with …
            
            

                
                Dose: 350 mg
                
                
                so với: None
                
                
                Outcome: IBS symptom improvement
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Irritable bowel syndrome with diarrhea and antibiotic-associated diarr

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=100
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in …
            
            

                
                Dose: 100 mL/day fermented milk
                
                
                so với: Placebo fermented milk
                
                
                Outcome: GI symptom scores (m-FSSG, GSRS)
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Healthy Japanese adults with GI discomfort

            
        

        
        

            

                
                    Other
                
                
                
                4.0 weeks
                
                
            

            
                Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms …
            
            

                
                Dose: 100 mL/day
                
                
                so với: None
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: men

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
                Double-blind
                
            

            
                Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or …
            
            

                
                Dose: None
                
                
                so với: Placebo + eradication regimen
                
                
                Outcome: H. pylori eradication rate and adverse effects
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Adults with H. pylori infection

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Nghiên cứu

    

    

        
500

        
Người tham gia

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Xếp hạng

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Voprosy pitaniia
                        2023
                        
                    

                

                
                

                    

                        
                            Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Journal of dairy …
                        2018
                        
                        51 trích dẫn
                        
                    

                

                
                

                    

                        
                            Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Bioscience of microbiota, …
                        2015
                        
                        40 trích dẫn
                        
                    

                

                
                

                    

                        
                            Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        BMC gastroenterology
                        2013
                        
                        70 trích dẫn
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Liều lượng thường dùng

                

                    
                    

                        
general:

                        
1-10 billion CFU/day

                    

                    
                    

                        
dyspepsiasupport:

                        
1 billion CFU/day (YIT 10347 strain)

                    

                    
                

                
                

                    Giới hạn trên: Well-tolerated up to 10 billion CFU/day in clinical trials
                

                
            

            

            
            

                
Liều lượng đã nghiên cứu

                

                    

                        
                            

                                Liều lượng
                                Thời gian
                                Hiệu quả
                                N
                            

                        
                        
                            
                            

                                350 mg
                                3.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                54
                            

                            
                            

                                100 mL/day fermented milk
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                100
                            

                            
                            

                                100 mL/day
                                4.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Thời điểm dùng tốt nhất: On an empty stomach or before meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Tác dụng phụ đã được báo cáo

                    
    
                        
                        
  • 
                            ⚠
                            Mild gas and bloating during initial use
                        
    • 
                        
                        
  • 
                            ⚠
                            Occasional abdominal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare loose stools
                        
    • 
                        
                        
  • 
                            ⚠
                            Very rare: bacteremia in immunocompromised individuals
                        
    • 
                        
                    

                

                

                
                

                    
Tương tác đã biết

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressants (use with caution in immunocompromised patients)
                        
    • 
                        
                    

                

                

                
                

                    

                        Mức hấp thụ tối đa cho phép: Well-tolerated up to 10 billion CFU/day in clinical trials
                    

                

                
            

            

                Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Bifidobacterium bifidum help with Functional Dyspepsia?
            
        
        

            Based on 4 studies with 500 participants, there is limited but promising evidence that Bifidobacterium bifidum may support Functional Dyspepsia management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Bifidobacterium bifidum should I take for Functional Dyspepsia?
            
        
        

            Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Bifidobacterium bifidum?
            
        
        

            Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Bifidobacterium bifidum and Functional Dyspepsia?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Các thành phần khác cho Functional Dyspepsia

                    

                        
                        
                            Ginger
                            B

                        
                        
                        
                            Deglycyrrhizinated Licorice (DGL)
                            C

                        
                        
                    

                

                

                
            

        

        

    


    
    












    

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