Vitamin D для Irritable Bowel Syndrome (IBS)
CLimited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
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C
Итог
Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
или: None
Outcome: IBS symptom improvement with vitamin D supplementation
Эффект: None
None
Популяция: individuals with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
или: Various
Outcome: IBS symptom improvement
Эффект: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
Популяция: Adult IBS patients
Meta-Analysis
Double-blind
The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …
Dose: 3,000 IU daily to 50,000 IU bi-weekly
или: Placebo
Outcome: IBS symptom severity and quality of life
Эффект: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1
None
Популяция: Adults with IBS and deficient/insufficient vitamin D
Review
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.
Dose: None
или: None
Outcome: Risk of developing Parkinson's disease
Эффект: None
None
Популяция: General population (narrative review of PD risk factors)
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
или: None
Outcome: Micronutrient deficiency management in pediatric IBD
Эффект: None
None
Популяция: Children with inflammatory bowel disease (review)
Review
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Dose: None
или: None
Outcome: IBS symptom relief and pathophysiology modulation
Эффект: None
None
Популяция: Patients with irritable bowel syndrome (review)
Key Statistics
3
Исследования
400
Участники
↑
Positive
C
Оценка
Referenced Papers
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None
4 цитирований
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
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2025
10 цитирований
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Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Review
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Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and …
Systematic Review
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Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
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30 цитирований
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Systematic Review
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The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis.
Meta-Analysis
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The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome …
Meta-Analysis
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24 цитирований
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Other
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2022
7 цитирований
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2022
4 цитирований
Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review.
Systematic Review
Nutrients
2021
16 цитирований
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Other
Journal of gastroenterology …
2021
10 цитирований
Zhongguo dang dai …
2021
The journal of …
2020
294 цитирований
The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis.
Meta-Analysis
Osteoporosis international : …
2020
14 цитирований
Cureus
2020
10 цитирований
Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D.
Review
Expert review of …
2019
33 цитирований
Medicine
2019
4 цитирований
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
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2018
39 цитирований
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2018
38 цитирований
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2017
280 цитирований
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2016
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Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
Верхний предел: 4,000 IU/day (100 mcg); higher doses under medical supervision only
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 3,000 IU daily to 50,000 IU bi-weekly | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 240 |
Лучшее время приёма: With a meal containing fat for better absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
Известные взаимодействия
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Допустимый верхний уровень потребления: 4,000 IU/day (100 mcg); higher doses under medical supervision only
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Vitamin D help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Irritable Bowel Syndrome (IBS)
Vitamin D для других состояний
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