Saccharomyces boulardii для Antibiotic-Associated Diarrhea (AAD)
AMultiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
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A
Итог
Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
или: None
Outcome: Probiotic prescribing habits of Italian PCPs
Эффект: L. rhamnosus GG used by 91.8%
None
Популяция: Italian primary care pediatricians
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Pediatric population
Review
Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: scoping review of intestinal dysbiosis definition, symptoms, and probiotic adjuvant therapy in adults and children
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
или: None
Outcome: Clinical guideline recommendations for pediatric GI
Эффект: None
None
Популяция: Pediatric patients with GI disorders
Review
Clostridioides difficile Infections: Prevention and Treatment Strategies.
Dose: None
или: None
Outcome: C. difficile infection treatment outcomes
Эффект: None
None
Популяция: Patients with C. difficile infection
Randomized Controlled Trial
n=47
1 weeks
[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants …
Dose: None
или: Control
Outcome: Gut microbiota composition
Эффект: None
P<0.017
Популяция: Children
Key Statistics
25
Исследования
5000
Участники
↑
Positive
A
Оценка
Referenced Papers
Probiotics and antimicrobial …
2025
26 цитирований
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 цитирований
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Open forum infectious …
2024
7 цитирований
Zhongguo dang dai …
2024
5 цитирований
Advances in experimental …
2024
2 цитирований
Therapeutic advances in …
2023
97 цитирований
Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
Systematic Review
Frontiers in pharmacology
2023
20 цитирований
Cureus
2023
19 цитирований
Cureus
2023
5 цитирований
The Journal of …
2023
1 цитирований
Archivos argentinos de …
2022
23 цитирований
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
World journal of …
2019
92 цитирований
Advances in experimental …
2019
17 цитирований
Frontiers in medicine
2018
450 цитирований
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
PloS one
2018
205 цитирований
Pharmacological research
2018
132 цитирований
World journal of …
2018
52 цитирований
The American journal …
2018
46 цитирований
World journal of …
2017
68 цитирований
Journal of pediatric …
2016
233 цитирований
Clinical and experimental …
2016
82 цитирований
Open forum infectious …
2016
58 цитирований
Digestive diseases (Basel, …
2016
37 цитирований
The Cochrane database …
2015
233 цитирований
Antibiotics (Basel, Switzerland)
2015
104 цитирований
Journal of clinical …
2015
35 цитирований
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 цитирований
Nutricion hospitalaria
2015
5 цитирований
Expert opinion on …
2014
57 цитирований
MMW Fortschritte der …
2014
14 цитирований
MMW Fortschritte der …
2014
3 цитирований
The American journal …
2012
104 цитирований
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
Other
The American journal …
2012
5 цитирований
Medycyna wieku rozwojowego
2012
1 цитирований
Journal of clinical …
2011
432 цитирований
World journal of …
2010
512 цитирований
Journal for specialists …
2010
22 цитирований
Probiotics.
Review
American journal of …
2010
European journal of …
2009
91 цитирований
Current opinion in …
2009
82 цитирований
Advances in biochemical …
2008
535 цитирований
Journal of clinical …
2008
Probiotics.
Review
American family physician
2008
The Journal of …
2007
265 цитирований
The Cochrane database …
2007
The American journal …
2006
918 цитирований
Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials.
Meta-Analysis
CMAJ : Canadian …
2006
197 цитирований
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 цитирований
Medical science monitor …
2006
The American journal …
2001
648 цитирований
International journal of …
2000
181 цитирований
Clinical infectious diseases …
1998
346 цитирований
Anaerobe
1997
40 цитирований
Gastroenterology
1989
418 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
Верхний предел: Well-tolerated up to 1,000 mg/day in clinical trials
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | 47 |
| None | 20 weeks | Positive | 564 |
| None | -- | Positive | -- |
Лучшее время приёма: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
Известные взаимодействия
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
Допустимый верхний уровень потребления: Well-tolerated up to 1,000 mg/day in clinical trials
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Saccharomyces boulardii help with Antibiotic-Associated Diarrhea (AAD)?
Based on 25 studies with 5,000 participants, there is strong evidence from multiple clinical trials that Saccharomyces boulardii may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Saccharomyces boulardii should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Antibiotic-Associated Diarrhea (AAD)
Saccharomyces boulardii для других состояний
Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.