Saccharomyces boulardii ： Antibiotic-Associated Diarrhea (AAD)
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
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A
結論
Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
効果: L. rhamnosus GG used by 91.8%
None
対象集団: Italian primary care pediatricians
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Pediatric population
Review
Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: scoping review of intestinal dysbiosis definition, symptoms, and probiotic adjuvant therapy in adults and children
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
効果: None
None
対象集団: Pediatric patients with GI disorders
Review
Clostridioides difficile Infections: Prevention and Treatment Strategies.
Dose: None
vs: None
Outcome: C. difficile infection treatment outcomes
効果: None
None
対象集団: Patients with C. difficile infection
Randomized Controlled Trial
n=47
1 weeks
[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants …
Dose: None
vs: Control
Outcome: Gut microbiota composition
効果: None
P<0.017
対象集団: Children
Key Statistics
25
研究数
5000
参加者数
↑
Positive
A
グレード
Referenced Papers
Probiotics and antimicrobial …
2025
26 件の引用
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 件の引用
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Open forum infectious …
2024
7 件の引用
Zhongguo dang dai …
2024
5 件の引用
Advances in experimental …
2024
2 件の引用
Therapeutic advances in …
2023
97 件の引用
Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
Systematic Review
Frontiers in pharmacology
2023
20 件の引用
Cureus
2023
19 件の引用
Cureus
2023
5 件の引用
The Journal of …
2023
1 件の引用
Archivos argentinos de …
2022
23 件の引用
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
World journal of …
2019
92 件の引用
Advances in experimental …
2019
17 件の引用
Frontiers in medicine
2018
450 件の引用
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
PloS one
2018
205 件の引用
Pharmacological research
2018
132 件の引用
World journal of …
2018
52 件の引用
The American journal …
2018
46 件の引用
World journal of …
2017
68 件の引用
Journal of pediatric …
2016
233 件の引用
Clinical and experimental …
2016
82 件の引用
Open forum infectious …
2016
58 件の引用
Digestive diseases (Basel, …
2016
37 件の引用
The Cochrane database …
2015
233 件の引用
Antibiotics (Basel, Switzerland)
2015
104 件の引用
Journal of clinical …
2015
35 件の引用
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 件の引用
Nutricion hospitalaria
2015
5 件の引用
Expert opinion on …
2014
57 件の引用
MMW Fortschritte der …
2014
14 件の引用
MMW Fortschritte der …
2014
3 件の引用
The American journal …
2012
104 件の引用
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
Other
The American journal …
2012
5 件の引用
Medycyna wieku rozwojowego
2012
1 件の引用
Journal of clinical …
2011
432 件の引用
World journal of …
2010
512 件の引用
Journal for specialists …
2010
22 件の引用
Probiotics.
Review
American journal of …
2010
European journal of …
2009
91 件の引用
Current opinion in …
2009
82 件の引用
Advances in biochemical …
2008
535 件の引用
Journal of clinical …
2008
Probiotics.
Review
American family physician
2008
The Journal of …
2007
265 件の引用
The Cochrane database …
2007
The American journal …
2006
918 件の引用
Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials.
Meta-Analysis
CMAJ : Canadian …
2006
197 件の引用
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 件の引用
Medical science monitor …
2006
The American journal …
2001
648 件の引用
International journal of …
2000
181 件の引用
Clinical infectious diseases …
1998
346 件の引用
Anaerobe
1997
40 件の引用
Gastroenterology
1989
418 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
上限量： Well-tolerated up to 1,000 mg/day in clinical trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | 47 |
| None | 20 weeks | Positive | 564 |
| None | -- | Positive | -- |
推奨摂取タイミング： Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
報告されている副作用
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
既知の相互作用
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
耐容上限摂取量： Well-tolerated up to 1,000 mg/day in clinical trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Saccharomyces boulardii help with Antibiotic-Associated Diarrhea (AAD)?
Based on 25 studies with 5,000 participants, there is strong evidence from multiple clinical trials that Saccharomyces boulardii may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Saccharomyces boulardii should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Antibiotic-Associated Diarrhea (AAD)
Saccharomyces boulardii 他の症状・状態について
References
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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。