Saccharomyces boulardii per Antibiotic-Associated Diarrhea (AAD)
AMultiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
In sintesi
Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
Key Study Findings
Popolazione: Italian primary care pediatricians
Popolazione: Pediatric population
Popolazione: scoping review of intestinal dysbiosis definition, symptoms, and probiotic adjuvant therapy in adults and children
Popolazione: Pediatric patients with GI disorders
Popolazione: Patients with C. difficile infection
Popolazione: Children
Key Statistics
25
Studi
5000
Partecipanti
Positive
Grado
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
Limite massimo: Well-tolerated up to 1,000 mg/day in clinical trials
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | 47 |
| None | 20 weeks | Positive | 564 |
| None | -- | Positive | -- |
Momento migliore per l'assunzione: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
Interazioni note
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
Livello di assunzione massimo tollerabile: Well-tolerated up to 1,000 mg/day in clinical trials
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Saccharomyces boulardii help with Antibiotic-Associated Diarrhea (AAD)?
How much Saccharomyces boulardii should I take for Antibiotic-Associated Diarrhea (AAD)?
Are there side effects of Saccharomyces boulardii?
How strong is the evidence for Saccharomyces boulardii and Antibiotic-Associated Diarrhea (AAD)?
Related Evidence
Altri ingredienti per Antibiotic-Associated Diarrhea (AAD)
Saccharomyces boulardii per altre condizioni
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