Saccharomyces boulardii لـ Antibiotic-Associated Diarrhea (AAD)
AMultiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
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A
الخلاصة
Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
مقابل: None
Outcome: Probiotic prescribing habits of Italian PCPs
التأثير: L. rhamnosus GG used by 91.8%
None
المجتمع المدروس: Italian primary care pediatricians
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Pediatric population
Review
Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: scoping review of intestinal dysbiosis definition, symptoms, and probiotic adjuvant therapy in adults and children
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
مقابل: None
Outcome: Clinical guideline recommendations for pediatric GI
التأثير: None
None
المجتمع المدروس: Pediatric patients with GI disorders
Review
Clostridioides difficile Infections: Prevention and Treatment Strategies.
Dose: None
مقابل: None
Outcome: C. difficile infection treatment outcomes
التأثير: None
None
المجتمع المدروس: Patients with C. difficile infection
Randomized Controlled Trial
n=47
1 weeks
[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants …
Dose: None
مقابل: Control
Outcome: Gut microbiota composition
التأثير: None
P<0.017
المجتمع المدروس: Children
Key Statistics
25
الدراسات
5000
المشاركون
↑
Positive
A
التقييم
Referenced Papers
Probiotics and antimicrobial …
2025
26 اقتباسات
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 اقتباسات
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Open forum infectious …
2024
7 اقتباسات
Zhongguo dang dai …
2024
5 اقتباسات
Advances in experimental …
2024
2 اقتباسات
Therapeutic advances in …
2023
97 اقتباسات
Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
Systematic Review
Frontiers in pharmacology
2023
20 اقتباسات
Cureus
2023
19 اقتباسات
Cureus
2023
5 اقتباسات
The Journal of …
2023
1 اقتباسات
Archivos argentinos de …
2022
23 اقتباسات
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
World journal of …
2019
92 اقتباسات
Advances in experimental …
2019
17 اقتباسات
Frontiers in medicine
2018
450 اقتباسات
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
PloS one
2018
205 اقتباسات
Pharmacological research
2018
132 اقتباسات
World journal of …
2018
52 اقتباسات
The American journal …
2018
46 اقتباسات
World journal of …
2017
68 اقتباسات
Journal of pediatric …
2016
233 اقتباسات
Clinical and experimental …
2016
82 اقتباسات
Open forum infectious …
2016
58 اقتباسات
Digestive diseases (Basel, …
2016
37 اقتباسات
The Cochrane database …
2015
233 اقتباسات
Antibiotics (Basel, Switzerland)
2015
104 اقتباسات
Journal of clinical …
2015
35 اقتباسات
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 اقتباسات
Nutricion hospitalaria
2015
5 اقتباسات
Expert opinion on …
2014
57 اقتباسات
MMW Fortschritte der …
2014
14 اقتباسات
MMW Fortschritte der …
2014
3 اقتباسات
The American journal …
2012
104 اقتباسات
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
Other
The American journal …
2012
5 اقتباسات
Medycyna wieku rozwojowego
2012
1 اقتباسات
Journal of clinical …
2011
432 اقتباسات
World journal of …
2010
512 اقتباسات
Journal for specialists …
2010
22 اقتباسات
Probiotics.
Review
American journal of …
2010
European journal of …
2009
91 اقتباسات
Current opinion in …
2009
82 اقتباسات
Advances in biochemical …
2008
535 اقتباسات
Journal of clinical …
2008
Probiotics.
Review
American family physician
2008
The Journal of …
2007
265 اقتباسات
The Cochrane database …
2007
The American journal …
2006
918 اقتباسات
Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials.
Meta-Analysis
CMAJ : Canadian …
2006
197 اقتباسات
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 اقتباسات
Medical science monitor …
2006
The American journal …
2001
648 اقتباسات
International journal of …
2000
181 اقتباسات
Clinical infectious diseases …
1998
346 اقتباسات
Anaerobe
1997
40 اقتباسات
Gastroenterology
1989
418 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
الحد الأعلى: Well-tolerated up to 1,000 mg/day in clinical trials
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | 47 |
| None | 20 weeks | Positive | 564 |
| None | -- | Positive | -- |
أفضل وقت للتناول: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
التفاعلات المعروفة
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
الحد الأقصى المسموح به: Well-tolerated up to 1,000 mg/day in clinical trials
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Saccharomyces boulardii help with Antibiotic-Associated Diarrhea (AAD)?
Based on 25 studies with 5,000 participants, there is strong evidence from multiple clinical trials that Saccharomyces boulardii may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Saccharomyces boulardii should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Antibiotic-Associated Diarrhea (AAD)
Saccharomyces boulardii لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.