사카로마이세스 보울라디 관련 여행자 설사

B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.

여행 5일 전부터 시작 시 RCT에서 여행자 설사가 25~40% 감소한 것으로 나타났습니다. 효과는 여행지에 따라 다릅니다.

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결론

여행 5일 전부터 시작 시 RCT에서 여행자 설사가 25~40% 감소한 것으로 나타났습니다. 효과는 여행지에 따라 다릅니다.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms 효과: None None

대상 집단: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial n=47 8 weeks Double-blind

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …

Dose: None vs: Placebo (Group I) and partial formulation (Group II) Outcome: IBS quality of life (QoL questionnaire) 효과: Dysphoria: median diff -5 (Group III) vs -1 (contr 0.0021 (dysphoria Group III)

대상 집단: Patients with IBS

Other

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …

Dose: None vs: None Outcome: Clinical guideline recommendations for pediatric GI 효과: None None

대상 집단: Pediatric patients with GI disorders

Observational Study n=279

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …

Dose: None vs: None Outcome: Probiotic prescribing habits of Italian PCPs 효과: L. rhamnosus GG used by 91.8% None

대상 집단: Italian primary care pediatricians

Other n=70 16 weeks Open-label

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.

Dose: None vs: None (single-arm study) Outcome: Constipation scoring system change 효과: -5.3 (95% CI -5.9/-4.7) 0.001

대상 집단: Peritoneal dialysis patients with chronic constipation

Review

An update on probiotics in paediatrics.

Dose: None vs: None Outcome: GI disorder outcomes in paediatrics 효과: None None

대상 집단: Paediatric patients with GI disorders

Key Statistics

연구

3200

참여자

↑

Positive

등급

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping Review. Review

Probiotics and antimicrobial … 2025 26 인용

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 인용

Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study. Other

Frontiers in cellular … 2025 3 인용

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients … Other

Frontiers in nutrition 2025 3 인용

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study. Other

Journal of renal … 2025

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care Pediatricians. Other

Antibiotics (Basel, Switzerland) 2025

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and nutrition: probiotics chapter. Other

Boletin medico del … 2025

An update on probiotics in paediatrics. Other

Current opinion in … 2025

High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A … Other

Open forum infectious … 2024 7 인용

[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children]. RCT

Zhongguo dang dai … 2024 5 인용

Clostridioides difficile Infections: Prevention and Treatment Strategies. Review

Advances in experimental … 2024 2 인용

Current understanding of antibiotic-associated dysbiosis and approaches for its management. Review

Therapeutic advances in … 2023 97 인용

Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Systematic Review

Frontiers in pharmacology 2023 20 인용

Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Review

Cureus 2023 19 인용

Qualitative Analysis of the Efficacy of Probiotic Strains in the Prevention of Antibiotic-Associated Diarrhea. Review

Cureus 2023 5 인용

The Role of Yeast Probiotics in Gastrointestinal Conditions: An Overview. Review

The Journal of … 2023 1 인용

Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Review

Archivos argentinos de … 2022 23 인용

Saccharomyces boulardii ameliorates gut dysbiosis associated cognitive decline. Other

Physiology & behavior 2021 35 인용

Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections. Review

World journal of … 2019 92 인용

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 인용

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ T cells ex vivo. Other

Applied microbiology and … 2019 25 인용

Clostridium difficile Colitis Prevention and Treatment. Review

Advances in experimental … 2019 17 인용

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Other

Frontiers in medicine 2018 450 인용

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide. Systematic Review

PloS one 2018 205 인용

Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment. Review

Pharmacological research 2018 132 인용

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. Meta-Analysis

PloS one 2018 76 인용

Chinese clinical practice guidelines for acute infectious diarrhea in children. Review

World journal of … 2018 52 인용

Probiotics in Gastroenterology: How Pro Is the Evidence in Adults? Review

The American journal … 2018 46 인용

Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. Review

British journal of … 2017 145 인용

Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Meta-Analysis

European journal of … 2017 93 인용

Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region. Review

World journal of … 2017 68 인용

Probiotics in Children: What Is the Evidence? Review

Pediatric gastroenterology, hepatology … 2017 42 인용

Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. Meta-Analysis

Journal of pediatric … 2016 233 인용

Influence of Saccharomyces boulardii CNCM I-745on the gut-associated immune system. Review

Clinical and experimental … 2016 82 인용

Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Other

Open forum infectious … 2016 58 인용

Probiotic Bacterial and Fungal Strains: Claims with Evidence. Review

Digestive diseases (Basel, … 2016 37 인용

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Meta-Analysis

The Cochrane database … 2015 233 인용

Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Review

Antibiotics (Basel, Switzerland) 2015 104 인용

Probiotics for Prevention and Treatment of Diarrhea. Review

Journal of clinical … 2015 35 인용

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Review

Nutrition in clinical … 2015 31 인용

[Probiotics for the treating acute diarrhea and preventing antibiotic-associated diarrhea in children]. Review

Nutricion hospitalaria 2015 5 인용

Saccharomyces boulardii CNCM I-745 in different clinical conditions. Review

Expert opinion on … 2014 57 인용

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Other

MMW Fortschritte der … 2014 14 인용

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Review

MMW Fortschritte der … 2014 3 인용

The role of probiotics and prebiotics in inducing gut immunity. Review

Frontiers in immunology 2013 263 인용

Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial. RCT

The American journal … 2012 104 인용

Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use. Other

The American journal … 2012 5 인용

[Effectiveness and safety of probiotics in children on the basis of clinical trials]. Review

Medycyna wieku rozwojowego 2012 1 인용

Probiotics for prevention and treatment of diarrhea. Review

Journal of clinical … 2011 432 인용

Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. Meta-Analysis

World journal of … 2010 512 인용

Preventive effects of different probiotic formulations on travelers' diarrhea model in wistar rats : preventive effects of probiotics on TD. Other

Digestive diseases and … 2010 45 인용

Probiotics: preventing antibiotic-associated diarrhea. Other

Journal for specialists … 2010 22 인용

Probiotics. Review

American journal of … 2010

Saccharomyces boulardii in childhood. Review

European journal of … 2009 91 인용

Probiotics as prevention and treatment for diarrhea. Review

Current opinion in … 2009 82 인용

Probiotics, prebiotics, and synbiotics. Review

Advances in biochemical … 2008 535 인용

Probiotics. Review

American family physician 2008

Probiotics for prevention of antibiotic-associated diarrhea. Review

Journal of clinical … 2008

Probiotics and prebiotics: effects on diarrhea. Review

The Journal of … 2007 265 인용

Probiotics and zinc in acute infectious gastroenteritis in children: are they effective? Review

Nutrition (Burbank, Los … 2007 39 인용

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Systematic Review

The Cochrane database … 2007

Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Meta-Analysis

The American journal … 2006 918 인용

Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. Meta-Analysis

CMAJ : Canadian … 2006 197 인용

Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea. Review

Journal of clinical … 2006 112 인용

Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study. RCT

Medical science monitor … 2006

Protection from gastrointestinal diseases with the use of probiotics. Review

The American journal … 2001 648 인용

Treatment and prevention of antibiotic associated diarrhea. Review

International journal of … 2000 181 인용

Mechanisms and management of antibiotic-associated diarrhea. Review

Clinical infectious diseases … 1998 346 인용

Pharmaceutical probiotics for the treatment of anaerobic and other infections. Other

Anaerobe 1997 40 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:: 250-500 mg/day (equivalent to 5-10 billion CFU)
aadprevention:: 500 mg/day (start with antibiotic, continue 7 days after)
cdiffprevention:: 500 mg twice daily as adjunct to standard therapy
travelersdiarrhea:: 250-500 mg/day starting 5 days before travel

상한량: Well-tolerated up to 1,000 mg/day in clinical trials

연구에서 사용된 용량

용량	기간	효과	N
None	--	Positive	--
None	8 weeks	Positive	47
None	--	Positive	--
None	--	Mixed	279
None	16 weeks	Positive	70
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--

권장 복용 시간: Can be taken with or without food; space 2 hours from antifungals

Safety & Side Effects

보고된 부작용

⚠ Mild gas and bloating
⚠ Rare: fungemia in critically ill patients with central venous catheters
⚠ Thirst (yeast may increase water requirements)
⚠ Very rare: potential environmental contamination risk in ICU settings

알려진 상호작용

● Antifungal medications (may kill S. boulardii, reducing effectiveness)
● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)

일일 최대 섭취 허용량: Well-tolerated up to 1,000 mg/day in clinical trials

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 사카로마이세스 보울라디 help with 여행자 설사?

Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that 사카로마이세스 보울라디 may support 여행자 설사 management. Our evidence grade is B (Good Evidence).

How much 사카로마이세스 보울라디 should I take for 여행자 설사?

Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 사카로마이세스 보울라디?

Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 사카로마이세스 보울라디 and 여행자 설사?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.

사카로마이세스 보울라디 다른 건강 상태에 대한 근거

항생제 관련 설사(AAD) A 클로스트리디오이데스 디피실 감염(CDI) B

한눈에 보기

여행 5일 전부터 시작 시 RCT에서 여행자 설사가 25~40% 감소한 것으로 나타났습니다. 효과는 여행지에 따라 다릅니다.

Evidence Strength72%

High confidence

연구 분석

RCT (3)Meta (7)Other (0)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 여행자 설사

자세히 알아보기

References

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[3] Kok-Ann Gwee et al.. J Gastroenterol Hepatol. 2025. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. doi:10.1111/jgh.16809 PubMed
[4] Qianfang Liu et al.. Front Cell Infect Microbiol. 2025. Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study. doi:10.3389/fcimb.2025.1575605 PubMed
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