Saccharomyces boulardii cho Traveler's Diarrhea

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RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.

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Kết luận

RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None so với: placebo Outcome: improvement in key IBS symptoms Hiệu quả: None None

Đối tượng nghiên cứu: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial n=47 8 weeks Double-blind

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …

Dose: None so với: Placebo (Group I) and partial formulation (Group II) Outcome: IBS quality of life (QoL questionnaire) Hiệu quả: Dysphoria: median diff -5 (Group III) vs -1 (contr 0.0021 (dysphoria Group III)

Đối tượng nghiên cứu: Patients with IBS

Other

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …

Dose: None so với: None Outcome: Clinical guideline recommendations for pediatric GI Hiệu quả: None None

Đối tượng nghiên cứu: Pediatric patients with GI disorders

Observational Study n=279

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …

Dose: None so với: None Outcome: Probiotic prescribing habits of Italian PCPs Hiệu quả: L. rhamnosus GG used by 91.8% None

Đối tượng nghiên cứu: Italian primary care pediatricians

Other n=70 16 weeks Open-label

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.

Dose: None so với: None (single-arm study) Outcome: Constipation scoring system change Hiệu quả: -5.3 (95% CI -5.9/-4.7) 0.001

Đối tượng nghiên cứu: Peritoneal dialysis patients with chronic constipation

Review

An update on probiotics in paediatrics.

Dose: None so với: None Outcome: GI disorder outcomes in paediatrics Hiệu quả: None None

Đối tượng nghiên cứu: Paediatric patients with GI disorders

Key Statistics

Nghiên cứu

3200

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping Review. Review

Probiotics and antimicrobial … 2025 26 trích dẫn

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 trích dẫn

Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study. Other

Frontiers in cellular … 2025 3 trích dẫn

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients … Other

Frontiers in nutrition 2025 3 trích dẫn

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study. Other

Journal of renal … 2025

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care Pediatricians. Other

Antibiotics (Basel, Switzerland) 2025

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and nutrition: probiotics chapter. Other

Boletin medico del … 2025

An update on probiotics in paediatrics. Other

Current opinion in … 2025

High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A … Other

Open forum infectious … 2024 7 trích dẫn

[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children]. RCT

Zhongguo dang dai … 2024 5 trích dẫn

Clostridioides difficile Infections: Prevention and Treatment Strategies. Review

Advances in experimental … 2024 2 trích dẫn

Current understanding of antibiotic-associated dysbiosis and approaches for its management. Review

Therapeutic advances in … 2023 97 trích dẫn

Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Systematic Review

Frontiers in pharmacology 2023 20 trích dẫn

Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Review

Cureus 2023 19 trích dẫn

Qualitative Analysis of the Efficacy of Probiotic Strains in the Prevention of Antibiotic-Associated Diarrhea. Review

Cureus 2023 5 trích dẫn

The Role of Yeast Probiotics in Gastrointestinal Conditions: An Overview. Review

The Journal of … 2023 1 trích dẫn

Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Review

Archivos argentinos de … 2022 23 trích dẫn

Saccharomyces boulardii ameliorates gut dysbiosis associated cognitive decline. Other

Physiology & behavior 2021 35 trích dẫn

Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections. Review

World journal of … 2019 92 trích dẫn

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 trích dẫn

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ T cells ex vivo. Other

Applied microbiology and … 2019 25 trích dẫn

Clostridium difficile Colitis Prevention and Treatment. Review

Advances in experimental … 2019 17 trích dẫn

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Other

Frontiers in medicine 2018 450 trích dẫn

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide. Systematic Review

PloS one 2018 205 trích dẫn

Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment. Review

Pharmacological research 2018 132 trích dẫn

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. Meta-Analysis

PloS one 2018 76 trích dẫn

Chinese clinical practice guidelines for acute infectious diarrhea in children. Review

World journal of … 2018 52 trích dẫn

Probiotics in Gastroenterology: How Pro Is the Evidence in Adults? Review

The American journal … 2018 46 trích dẫn

Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. Review

British journal of … 2017 145 trích dẫn

Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Meta-Analysis

European journal of … 2017 93 trích dẫn

Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region. Review

World journal of … 2017 68 trích dẫn

Probiotics in Children: What Is the Evidence? Review

Pediatric gastroenterology, hepatology … 2017 42 trích dẫn

Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. Meta-Analysis

Journal of pediatric … 2016 233 trích dẫn

Influence of Saccharomyces boulardii CNCM I-745on the gut-associated immune system. Review

Clinical and experimental … 2016 82 trích dẫn

Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Other

Open forum infectious … 2016 58 trích dẫn

Probiotic Bacterial and Fungal Strains: Claims with Evidence. Review

Digestive diseases (Basel, … 2016 37 trích dẫn

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Meta-Analysis

The Cochrane database … 2015 233 trích dẫn

Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Review

Antibiotics (Basel, Switzerland) 2015 104 trích dẫn

Probiotics for Prevention and Treatment of Diarrhea. Review

Journal of clinical … 2015 35 trích dẫn

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Review

Nutrition in clinical … 2015 31 trích dẫn

[Probiotics for the treating acute diarrhea and preventing antibiotic-associated diarrhea in children]. Review

Nutricion hospitalaria 2015 5 trích dẫn

Saccharomyces boulardii CNCM I-745 in different clinical conditions. Review

Expert opinion on … 2014 57 trích dẫn

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Other

MMW Fortschritte der … 2014 14 trích dẫn

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Review

MMW Fortschritte der … 2014 3 trích dẫn

The role of probiotics and prebiotics in inducing gut immunity. Review

Frontiers in immunology 2013 263 trích dẫn

Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial. RCT

The American journal … 2012 104 trích dẫn

Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use. Other

The American journal … 2012 5 trích dẫn

[Effectiveness and safety of probiotics in children on the basis of clinical trials]. Review

Medycyna wieku rozwojowego 2012 1 trích dẫn

Probiotics for prevention and treatment of diarrhea. Review

Journal of clinical … 2011 432 trích dẫn

Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. Meta-Analysis

World journal of … 2010 512 trích dẫn

Preventive effects of different probiotic formulations on travelers' diarrhea model in wistar rats : preventive effects of probiotics on TD. Other

Digestive diseases and … 2010 45 trích dẫn

Probiotics: preventing antibiotic-associated diarrhea. Other

Journal for specialists … 2010 22 trích dẫn

Probiotics. Review

American journal of … 2010

Saccharomyces boulardii in childhood. Review

European journal of … 2009 91 trích dẫn

Probiotics as prevention and treatment for diarrhea. Review

Current opinion in … 2009 82 trích dẫn

Probiotics, prebiotics, and synbiotics. Review

Advances in biochemical … 2008 535 trích dẫn

Probiotics. Review

American family physician 2008

Probiotics for prevention of antibiotic-associated diarrhea. Review

Journal of clinical … 2008

Probiotics and prebiotics: effects on diarrhea. Review

The Journal of … 2007 265 trích dẫn

Probiotics and zinc in acute infectious gastroenteritis in children: are they effective? Review

Nutrition (Burbank, Los … 2007 39 trích dẫn

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Systematic Review

The Cochrane database … 2007

Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Meta-Analysis

The American journal … 2006 918 trích dẫn

Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. Meta-Analysis

CMAJ : Canadian … 2006 197 trích dẫn

Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea. Review

Journal of clinical … 2006 112 trích dẫn

Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study. RCT

Medical science monitor … 2006

Protection from gastrointestinal diseases with the use of probiotics. Review

The American journal … 2001 648 trích dẫn

Treatment and prevention of antibiotic associated diarrhea. Review

International journal of … 2000 181 trích dẫn

Mechanisms and management of antibiotic-associated diarrhea. Review

Clinical infectious diseases … 1998 346 trích dẫn

Pharmaceutical probiotics for the treatment of anaerobic and other infections. Other

Anaerobe 1997 40 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 250-500 mg/day (equivalent to 5-10 billion CFU)
aadprevention:: 500 mg/day (start with antibiotic, continue 7 days after)
cdiffprevention:: 500 mg twice daily as adjunct to standard therapy
travelersdiarrhea:: 250-500 mg/day starting 5 days before travel

Giới hạn trên: Well-tolerated up to 1,000 mg/day in clinical trials

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	--
None	8 weeks	Positive	47
None	--	Positive	--
None	--	Mixed	279
None	16 weeks	Positive	70
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--

Thời điểm dùng tốt nhất: Can be taken with or without food; space 2 hours from antifungals

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Mild gas and bloating
⚠ Rare: fungemia in critically ill patients with central venous catheters
⚠ Thirst (yeast may increase water requirements)
⚠ Very rare: potential environmental contamination risk in ICU settings

Tương tác đã biết

● Antifungal medications (may kill S. boulardii, reducing effectiveness)
● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)

Mức hấp thụ tối đa cho phép: Well-tolerated up to 1,000 mg/day in clinical trials

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Saccharomyces boulardii help with Traveler's Diarrhea?

Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support Traveler's Diarrhea management. Our evidence grade is B (Good Evidence).

How much Saccharomyces boulardii should I take for Traveler's Diarrhea?

Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Saccharomyces boulardii?

Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Saccharomyces boulardii and Traveler's Diarrhea?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.

Các thành phần khác cho Traveler's Diarrhea

Bovine Colostrum B

Saccharomyces boulardii cho các tình trạng khác

Antibiotic-Associated Diarrhea (AAD) A Clostridioides difficile Infection (CDI) B

Đánh giá nhanh

RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (3)Meta (7)Other (0)

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Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho Traveler's Diarrhea

Tìm hiểu thêm

References

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Saccharomyces boulardii cho Traveler's Diarrhea

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