Saccharomyces boulardii 用于旅行者腹泻

B 证据至少一项随机试验支持这一结论，结果基本一致。

RCT显示，若在旅行前5天开始服用，可将旅行者腹泻减少25%至40%。效果因目的地不同而异。

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结论

RCT显示，若在旅行前5天开始服用，可将旅行者腹泻减少25%至40%。效果因目的地不同而异。

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms 效果: None None

研究人群: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial n=47 8 weeks Double-blind

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …

Dose: None vs: Placebo (Group I) and partial formulation (Group II) Outcome: IBS quality of life (QoL questionnaire) 效果: Dysphoria: median diff -5 (Group III) vs -1 (contr 0.0021 (dysphoria Group III)

研究人群: Patients with IBS

Other

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …

Dose: None vs: None Outcome: Clinical guideline recommendations for pediatric GI 效果: None None

研究人群: Pediatric patients with GI disorders

Observational Study n=279

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …

Dose: None vs: None Outcome: Probiotic prescribing habits of Italian PCPs 效果: L. rhamnosus GG used by 91.8% None

研究人群: Italian primary care pediatricians

Other n=70 16 weeks Open-label

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.

Dose: None vs: None (single-arm study) Outcome: Constipation scoring system change 效果: -5.3 (95% CI -5.9/-4.7) 0.001

研究人群: Peritoneal dialysis patients with chronic constipation

Review

An update on probiotics in paediatrics.

Dose: None vs: None Outcome: GI disorder outcomes in paediatrics 效果: None None

研究人群: Paediatric patients with GI disorders

Key Statistics

研究数量

3200

受试者

↑

Positive

等级

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping Review. Review

Probiotics and antimicrobial … 2025 26 次引用

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 次引用

Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study. Other

Frontiers in cellular … 2025 3 次引用

Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients … Other

Frontiers in nutrition 2025 3 次引用

Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study. Other

Journal of renal … 2025

Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care Pediatricians. Other

Antibiotics (Basel, Switzerland) 2025

Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and nutrition: probiotics chapter. Other

Boletin medico del … 2025

An update on probiotics in paediatrics. Other

Current opinion in … 2025

High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A … Other

Open forum infectious … 2024 7 次引用

[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children]. RCT

Zhongguo dang dai … 2024 5 次引用

Clostridioides difficile Infections: Prevention and Treatment Strategies. Review

Advances in experimental … 2024 2 次引用

Current understanding of antibiotic-associated dysbiosis and approaches for its management. Review

Therapeutic advances in … 2023 97 次引用

Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Systematic Review

Frontiers in pharmacology 2023 20 次引用

Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Review

Cureus 2023 19 次引用

Qualitative Analysis of the Efficacy of Probiotic Strains in the Prevention of Antibiotic-Associated Diarrhea. Review

Cureus 2023 5 次引用

The Role of Yeast Probiotics in Gastrointestinal Conditions: An Overview. Review

The Journal of … 2023 1 次引用

Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Review

Archivos argentinos de … 2022 23 次引用

Saccharomyces boulardii ameliorates gut dysbiosis associated cognitive decline. Other

Physiology & behavior 2021 35 次引用

Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections. Review

World journal of … 2019 92 次引用

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 次引用

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ T cells ex vivo. Other

Applied microbiology and … 2019 25 次引用

Clostridium difficile Colitis Prevention and Treatment. Review

Advances in experimental … 2019 17 次引用

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Other

Frontiers in medicine 2018 450 次引用

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide. Systematic Review

PloS one 2018 205 次引用

Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment. Review

Pharmacological research 2018 132 次引用

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. Meta-Analysis

PloS one 2018 76 次引用

Chinese clinical practice guidelines for acute infectious diarrhea in children. Review

World journal of … 2018 52 次引用

Probiotics in Gastroenterology: How Pro Is the Evidence in Adults? Review

The American journal … 2018 46 次引用

Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. Review

British journal of … 2017 145 次引用

Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Meta-Analysis

European journal of … 2017 93 次引用

Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region. Review

World journal of … 2017 68 次引用

Probiotics in Children: What Is the Evidence? Review

Pediatric gastroenterology, hepatology … 2017 42 次引用

Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. Meta-Analysis

Journal of pediatric … 2016 233 次引用

Influence of Saccharomyces boulardii CNCM I-745on the gut-associated immune system. Review

Clinical and experimental … 2016 82 次引用

Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Other

Open forum infectious … 2016 58 次引用

Probiotic Bacterial and Fungal Strains: Claims with Evidence. Review

Digestive diseases (Basel, … 2016 37 次引用

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Meta-Analysis

The Cochrane database … 2015 233 次引用

Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Review

Antibiotics (Basel, Switzerland) 2015 104 次引用

Probiotics for Prevention and Treatment of Diarrhea. Review

Journal of clinical … 2015 35 次引用

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Review

Nutrition in clinical … 2015 31 次引用

[Probiotics for the treating acute diarrhea and preventing antibiotic-associated diarrhea in children]. Review

Nutricion hospitalaria 2015 5 次引用

Saccharomyces boulardii CNCM I-745 in different clinical conditions. Review

Expert opinion on … 2014 57 次引用

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Other

MMW Fortschritte der … 2014 14 次引用

[Saccharomyces boulardii in the treatment and prevention of antibiotic-associated diarrhea]. Review

MMW Fortschritte der … 2014 3 次引用

The role of probiotics and prebiotics in inducing gut immunity. Review

Frontiers in immunology 2013 263 次引用

Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial. RCT

The American journal … 2012 104 次引用

Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use. Other

The American journal … 2012 5 次引用

[Effectiveness and safety of probiotics in children on the basis of clinical trials]. Review

Medycyna wieku rozwojowego 2012 1 次引用

Probiotics for prevention and treatment of diarrhea. Review

Journal of clinical … 2011 432 次引用

Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. Meta-Analysis

World journal of … 2010 512 次引用

Preventive effects of different probiotic formulations on travelers' diarrhea model in wistar rats : preventive effects of probiotics on TD. Other

Digestive diseases and … 2010 45 次引用

Probiotics: preventing antibiotic-associated diarrhea. Other

Journal for specialists … 2010 22 次引用

Probiotics. Review

American journal of … 2010

Saccharomyces boulardii in childhood. Review

European journal of … 2009 91 次引用

Probiotics as prevention and treatment for diarrhea. Review

Current opinion in … 2009 82 次引用

Probiotics, prebiotics, and synbiotics. Review

Advances in biochemical … 2008 535 次引用

Probiotics. Review

American family physician 2008

Probiotics for prevention of antibiotic-associated diarrhea. Review

Journal of clinical … 2008

Probiotics and prebiotics: effects on diarrhea. Review

The Journal of … 2007 265 次引用

Probiotics and zinc in acute infectious gastroenteritis in children: are they effective? Review

Nutrition (Burbank, Los … 2007 39 次引用

Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Systematic Review

The Cochrane database … 2007

Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Meta-Analysis

The American journal … 2006 918 次引用

Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. Meta-Analysis

CMAJ : Canadian … 2006 197 次引用

Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea. Review

Journal of clinical … 2006 112 次引用

Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study. RCT

Medical science monitor … 2006

Protection from gastrointestinal diseases with the use of probiotics. Review

The American journal … 2001 648 次引用

Treatment and prevention of antibiotic associated diarrhea. Review

International journal of … 2000 181 次引用

Mechanisms and management of antibiotic-associated diarrhea. Review

Clinical infectious diseases … 1998 346 次引用

Pharmaceutical probiotics for the treatment of anaerobic and other infections. Other

Anaerobe 1997 40 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 250-500 mg/day (equivalent to 5-10 billion CFU)
aadprevention:: 500 mg/day (start with antibiotic, continue 7 days after)
cdiffprevention:: 500 mg twice daily as adjunct to standard therapy
travelersdiarrhea:: 250-500 mg/day starting 5 days before travel

上限： Well-tolerated up to 1,000 mg/day in clinical trials

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	8 weeks	Positive	47
None	--	Positive	--
None	--	Mixed	279
None	16 weeks	Positive	70
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--

最佳服用时间： Can be taken with or without food; space 2 hours from antifungals

Safety & Side Effects

已报告的副作用

⚠ Mild gas and bloating
⚠ Rare: fungemia in critically ill patients with central venous catheters
⚠ Thirst (yeast may increase water requirements)
⚠ Very rare: potential environmental contamination risk in ICU settings

已知相互作用

● Antifungal medications (may kill S. boulardii, reducing effectiveness)
● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)

可耐受最高摄入量： Well-tolerated up to 1,000 mg/day in clinical trials

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Saccharomyces boulardii help with 旅行者腹泻?

Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support 旅行者腹泻 management. Our evidence grade is B (Good Evidence).

How much Saccharomyces boulardii should I take for 旅行者腹泻?

Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Saccharomyces boulardii?

Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Saccharomyces boulardii and 旅行者腹泻?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.

其他成分用于旅行者腹泻

Bovine Colostrum B

Saccharomyces boulardii 用于其他健康状况

抗生素相关性腹泻（AAD） A 艰难梭菌感染（CDI） B

快速结论

RCT显示，若在旅行前5天开始服用，可将旅行者腹泻减少25%至40%。效果因目的地不同而异。

Evidence Strength72%

High confidence

研究分析

RCT (3)Meta (7)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于旅行者腹泻

了解更多

References

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Saccharomyces boulardii 用于 旅行者腹泻

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研究中使用的剂量

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其他成分用于 旅行者腹泻

Saccharomyces boulardii 用于其他健康状况

References

Saccharomyces boulardii 用于旅行者腹泻

其他成分用于旅行者腹泻