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Alpha-Galactosidase cho Bloating and Intestinal Gas

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Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

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Kết luận

            
            
Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: None

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
                Double-blind
                
            

            
                A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …
            
            

                
                Dose: 1200 G
                
                
                so với: placebo
                
                
                Outcome: every 30 min during 7
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: patients with ibs after three standardized

            
        

        
        

            

                
                    Other
                
                
                n=17
                
                
                
            

            
                FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.
            
            

                
                Dose: None
                
                
                so với: no treatment
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: fabry disease but are often nonspecific

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=31
                
                
                2.0 weeks
                
                
                Double-blind
                
            

            
                Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
            
            

                
                Dose: 300 GALU or 150 GALU
                
                
                so với: Placebo (glucose)
                
                
                Outcome: GI symptom severity on VAS
                
                
                Hiệu quả: None
                
                
                pP0.006
                
            

            
            
Đối tượng nghiên cứu: IBS patients (Rome III, H2 producers)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=125
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                Does oral α-galactosidase relieve irritable bowel symptoms?
            
            

                
                Dose: alpha-galactosidase 600 GalU per meal
                
                
                so với: placebo
                
                
                Outcome: overall IBS symptom relief
                
                
                Hiệu quả: no significant difference vs placebo
                
                
                >0.05
                
            

            
            
Đối tượng nghiên cứu: IBS patients

            
        

        
        

            

                
                    Case Reports
                
                
                
                
            

            
                A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha …
            
            

                
                Dose: 3.7nmol/mL/h
                
                
                so với: None
                
                
                Outcome: None
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Nghiên cứu

    

    

        
300

        
Người tham gia

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Xếp hạng

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2021
                        
                        16 trích dẫn
                        
                    

                

                
                

                    

                        
                            FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Quality of life …
                        2021
                        
                        14 trích dẫn
                        
                    

                

                
                

                    

                        
                            A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Neurogastroenterology and motility
                        2021
                        
                        4 trích dẫn
                        
                    

                

                
                

                    

                        
                            Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2018
                        
                        49 trích dẫn
                        
                    

                

                
                

                    

                        
                            Does oral α-galactosidase relieve irritable bowel symptoms?
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Scandinavian journal of …
                        2016
                        
                        17 trích dẫn
                        
                    

                

                
                

                    

                        
                            A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene.
                        
                        
                            
                                Case Report
                            
                            
                            
                        
                    

                    

                        Clinical biochemistry
                        2015
                        
                        18 trích dẫn
                        
                    

                

                
                

                    

                        
                            Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        BMC gastroenterology
                        2013
                        
                        12 trích dẫn
                        
                    

                

                
                

                    

                        
                            The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Digestive diseases and …
                        2007
                        
                        45 trích dẫn
                        
                    

                

                
                

                    

                        
                            Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Molecular genetics and …
                        2005
                        
                        84 trích dẫn
                        
                    

                

                
                

                    

                        
                            Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The Journal of …
                        1994
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Liều lượng thường dùng

                

                    
                    

                        
general:

                        
150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods

                    

                    
                    

                        
standardbeanodose:

                        
300 GalU (2-3 tablets) with first bite of problem food

                    

                    
                

                
                

                    Giới hạn trên: No established upper limit; adjust per meal as needed
                

                
            

            

            
            

                
Liều lượng đã nghiên cứu

                

                    

                        
                            

                                Liều lượng
                                Thời gian
                                Hiệu quả
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                1200 G
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                17
                            

                            
                            

                                300 GALU or 150 GALU
                                2.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                31
                            

                            
                            

                                alpha-galactosidase 600 GalU per meal
                                4 weeks
                                
                                    
                                    Neutral
                                    
                                
                                125
                            

                            
                            

                                3.7nmol/mL/h
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                2 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                300 or 1200 GalU
                                --
                                
                                    
                                    Positive
                                    
                                
                                8
                            

                            
                        
                    

                

            

            

            
            

                Thời điểm dùng tốt nhất: With the first bite of gas-producing food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Tác dụng phụ đã được báo cáo

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare allergic reactions to mold-derived enzyme (Aspergillus source)
                        
    • 
                        
                        
  • 
                            ⚠
                            May cause mild GI discomfort in rare cases
                        
    • 
                        
                    

                

                

                
                

                    
Tương tác đã biết

                    
    
                        
                        
  • 
                            ●
                            Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
                        
    • 
                        
                        
  • 
                            ●
                            Miglitol (similar mechanism conflict as acarbose)
                        
    • 
                        
                    

                

                

                
                

                    

                        Mức hấp thụ tối đa cho phép: No established upper limit; adjust per meal as needed
                    

                

                
            

            

                Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Alpha-Galactosidase help with Bloating and Intestinal Gas?
            
        
        

            Based on 4 studies with 300 participants, there is moderate evidence from clinical studies that Alpha-Galactosidase may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Alpha-Galactosidase should I take for Bloating and Intestinal Gas?
            
        
        

            Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Alpha-Galactosidase?
            
        
        

            Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Alpha-Galactosidase and Bloating and Intestinal Gas?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Alpha-Galactosidase cho các tình trạng khác

                    

                        
                        
                            Irritable Bowel Syndrome (IBS)
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Fabio Caputo et al..
      Int J Environ Res Public Health.
      2021.
      Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
      doi:10.3390/ijerph18063320
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Alan L Shields et al..
      Qual Life Res.
      2021.
      FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.
      doi:10.1007/s11136-021-02847-9
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Lena Böhn et al..
      Neurogastroenterol Motil.
      2021.
      A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome …
      doi:10.1111/nmo.14094
      PubMed
    
    4. 
    
    
  4. 
      [4]
      C J Tuck et al..
      Am J Gastroenterol.
      2018.
      Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
      doi:10.1038/ajg.2017.245
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Markku Hillilä et al..
      Scand J Gastroenterol.
      2016.
      Does oral α-galactosidase relieve irritable bowel symptoms?
      doi:10.3109/00365521.2015.1063156
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Antonino Tuttolomondo et al..
      Clin Biochem.
      2015.
      A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene.
      doi:10.1016/j.clinbiochem.2014.09.018
      PubMed
    
    7. 
    
    
  7. 
      [7]
      Giovanni Di Nardo et al..
      BMC Gastroenterol.
      2013.
      Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial.
      doi:10.1186/1471-230X-13-142
      PubMed
    
    8. 
    
    
  8. 
      [8]
      Michele Di Stefano et al..
      Dig Dis Sci.
      2007.
      The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms.
      doi:10.1007/s10620-006-9296-9
      PubMed
    
    9. 
    
    
  9. 
      [9]
      Maryam Banikazemi et al..
      Mol Genet Metab.
      2005.
      Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy.
      doi:10.1016/j.ymgme.2005.04.009
      PubMed
    
    10. 
    
    
  10. 
      [10]
      T G Ganiats et al..
      J Fam Pract.
      1994.
      Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance.
      
      PubMed
    
    11. 
    
  















    

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