Alpha-Galactosidase cho Bloating and Intestinal Gas

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

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Kết luận

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G so với: placebo Outcome: every 30 min during 7 Hiệu quả: None None

Đối tượng nghiên cứu: patients with ibs after three standardized

Other n=17

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.

Dose: None so với: no treatment Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: fabry disease but are often nonspecific

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU so với: Placebo (glucose) Outcome: GI symptom severity on VAS Hiệu quả: None pP0.006

Đối tượng nghiên cứu: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal so với: placebo Outcome: overall IBS symptom relief Hiệu quả: no significant difference vs placebo >0.05

Đối tượng nghiên cứu: IBS patients

Case Reports

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha …

Dose: 3.7nmol/mL/h so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: patients

Key Statistics

Nghiên cứu

300

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 trích dẫn

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument. Other

Quality of life … 2021 14 trích dẫn

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 trích dẫn

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 trích dẫn

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 trích dẫn

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene. Case Report

Clinical biochemistry 2015 18 trích dẫn

Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial. RCT

BMC gastroenterology 2013 12 trích dẫn

The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. RCT

Digestive diseases and … 2007 45 trích dẫn

Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy. Other

Molecular genetics and … 2005 84 trích dẫn

Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. RCT

The Journal of … 1994

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

Giới hạn trên: No established upper limit; adjust per meal as needed

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Mixed	--
1200 G	--	Neutral	--
None	--	Positive	17
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125
3.7nmol/mL/h	--	Mixed	--
None	2 weeks	Positive	--
300 or 1200 GalU	--	Positive	8

Thời điểm dùng tốt nhất: With the first bite of gas-producing food

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

Tương tác đã biết

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

Mức hấp thụ tối đa cho phép: No established upper limit; adjust per meal as needed

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Alpha-Galactosidase help with Bloating and Intestinal Gas?

Based on 4 studies with 300 participants, there is moderate evidence from clinical studies that Alpha-Galactosidase may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).

How much Alpha-Galactosidase should I take for Bloating and Intestinal Gas?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Bloating and Intestinal Gas?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Bloating and Intestinal Gas

Pancreatic Enzymes (Pancrelipase) A Ginger B Lactobacillus reuteri B Medium-Chain Triglycerides (MCT Oil) C

Alpha-Galactosidase cho các tình trạng khác

Irritable Bowel Syndrome (IBS) D

Đánh giá nhanh

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (6)Meta (0)Other (0)

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