Lactobacillus rhamnosus GG ： Irritable Bowel Syndrome (IBS)

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

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結論

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms 効果: None None

対象集団: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial 3 weeks Double-blind

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review …

Dose: None vs: Placebo Outcome: Pain outcomes 効果: None None

対象集団: IBS patients

Systematic Review n=3

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic …

Dose: None vs: None Outcome: Abdominal pain frequency/intensity, constipation 効果: None None

対象集団: Children with FAPD or functional constipation

Systematic Review

Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.

Dose: various probiotic strains vs: placebo Outcome: IBS symptom improvement in children 効果: LGG showed benefit in some studies None

対象集団: Children with IBS

Review

Probiotic Bacterial and Fungal Strains: Claims with Evidence.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Various populations (probiotic claims review)

Review

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.

Dose: None vs: None Outcome: None 効果: None None

対象集団: IBD patients

Key Statistics

研究数

1200

参加者数

↑

Positive

グレード

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Review

Nutrients 2024 5 件の引用

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 件の引用

Probiotic Bacterial and Fungal Strains: Claims with Evidence. Review

Digestive diseases (Basel, … 2016 37 件の引用

Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. Systematic Review

Journal of pediatric … 2016 19 件の引用

The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Systematic Review

Paediatric drugs 2015 122 件の引用

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Review

Nutrition in clinical … 2015 31 件の引用

Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. RCT

BMC gastroenterology 2010 91 件の引用

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. RCT

Alimentary pharmacology & … 2007 102 件の引用

Intestinal colonisation, microbiota and future probiotics? Review

Asia Pacific journal … 2006 45 件の引用

Clinical studies on alleviating the symptoms of irritable bowel syndrome. RCT

Asia Pacific journal … 2006

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. RCT

Alimentary pharmacology & … 2005 398 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 10-20 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
aadprevention:: 10-20 billion CFU/day (start with antibiotic, continue 7 days after)

上限量： Generally well-tolerated up to 40 billion CFU/day in clinical trials

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	3 weeks	Positive	--
None	--	Mixed	3
various probiotic strains	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	26.0 weeks	Mixed	--

推奨摂取タイミング： On an empty stomach or 30 minutes before meals for optimal survival

Safety & Side Effects

報告されている副作用

⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
⚠ Rare reports of bacteremia in severely immunocompromised individuals
⚠ Occasional loose stools during adjustment period
⚠ Very rare: systemic infection in critically ill patients with central venous catheters

既知の相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
● Antifungals (no known interaction but may affect gut flora balance)

耐容上限摂取量： Generally well-tolerated up to 40 billion CFU/day in clinical trials

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Lactobacillus rhamnosus GG help with Irritable Bowel Syndrome (IBS)?

Based on 8 studies with 1,200 participants, there is moderate evidence from clinical studies that Lactobacillus rhamnosus GG may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus rhamnosus GG should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus rhamnosus GG?

Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus rhamnosus GG and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Irritable Bowel Syndrome (IBS)

Peppermint Oil A Psyllium Husk B Partially Hydrolyzed Guar Gum (PHGG) B Lactobacillus plantarum B Bifidobacterium longum B Galactooligosaccharides (GOS) B

Lactobacillus rhamnosus GG 他の症状・状態について

Antibiotic-Associated Diarrhea (AAD) A

総合評価

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

Evidence Strength72%

High confidence

研究の内訳

RCT (4)Meta (0)Other (4)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Irritable Bowel Syndrome (IBS)

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。