Bifidobacterium longum ： Irritable Bowel Syndrome (IBS)

RCTs demonstrate significant reduction in IBS composite symptom score versus placebo. Particular benefit for bloating and abdominal distension. Marketed as Alflorex/Align.

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結論

RCTs demonstrate significant reduction in IBS composite symptom score versus placebo. Particular benefit for bloating and abdominal distension. Marketed as Alflorex/Align.

Key Study Findings

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None vs: placebo Outcome: quality of life, depression, and anxiety in IBS … 効果: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

対象集団: patients with irritable bowel syndrome

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms 効果: None None

対象集団: patients with IBS from 32 RCTs evaluating 10 probiotic strains

In Vitro n=35

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …

Dose: 1e6 CFU/mL vs: IBS supernatants without probiotic Outcome: Caco-2 paracellular permeability 効果: None <0.001

対象集団: IBS patients (28) and asymptomatic controls (7)

Review

The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review.

Dose: None vs: None Outcome: IBS symptom management via NLRP3 inhibition 効果: None None

対象集団: Patients with IBS (narrative review)

Controlled Clinical Trial n=51 12 weeks Open-label

Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and …

Dose: None vs: Pre-treatment baseline Outcome: IBS-SSS score reduction 効果: None None

対象集団: IBS-D and IBS-C patients

Observational Study n=37 8 weeks Open-label

An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms …

Dose: None vs: None Outcome: Total IBS symptom score (TISS) 効果: 43.4% TISS reduction; >60% >=30% responders None

対象集団: Adults with IBS (Rome IV criteria)

Key Statistics

研究数

600

参加者数

↑

Positive

グレード

Referenced Papers

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Observational

Probiotics and antimicrobial … 2025 6 件の引用

The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review. Review

Microorganisms 2025 4 件の引用

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 Counteracts the Increase … Other

International journal of … 2025 4 件の引用

Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and Bifidobacterium longum W11. Other

Frontiers in medicine 2025 3 件の引用

Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. RCT

Gut microbes 2024 22 件の引用

Effect of Postbiotic Bifidobacterium longum CECT 7347 on Gastrointestinal Symptoms, Serum Biochemistry, and Intestinal Microbiota in Healthy Adults: A Randomised, … RCT

Nutrients 2024 13 件の引用

Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women. RCT

Microbiology spectrum 2024 9 件の引用

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 件の引用

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … Other

Journal of clinical … 2024 4 件の引用

Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome. Other

Nutrients 2024 4 件の引用

A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated … RCT

Gut microbes 2024

Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data. Other

Journal of translational … 2023 30 件の引用

Selenium-enriched Bifidobacterium longum DD98 relieves irritable bowel syndrome induced by chronic unpredictable mild stress in mice. Other

Food & function 2023 18 件の引用

Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination. Other

Neurogastroenterology and motility 2023 16 件の引用

The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. Other

Journal of gastroenterology … 2023 11 件の引用

[Long-term probiotic administration for irritable bowel syndrome: a legal need]. Observational

Terapevticheskii arkhiv 2023 3 件の引用

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. Observational

World journal of … 2022 27 件の引用

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 件の引用

Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children. Other

Journal of microbiology … 2022 15 件の引用

Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT. Other

Computational and structural … 2022 15 件の引用

Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome. Other

Scientific reports 2022 14 件の引用

[The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel … RCT

Terapevticheskii arkhiv 2022 6 件の引用

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 件の引用

The Effects of Human Milk Oligosaccharides on Gut Microbiota, Metabolite Profiles and Host Mucosal Response in Patients with Irritable Bowel … RCT

Nutrients 2021 36 件の引用

Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Review

Clinical nutrition ESPEN 2021 11 件の引用

[Prospects of probiotic strains of bifidobacteria and enterococcus in treatment and prevention of diseases in gastroenterology]. Review

Voprosy pitaniia 2021 3 件の引用

Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease … RCT

Gastroenterology 2020 290 件の引用

Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. RCT

European journal of … 2020 80 件の引用

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … RCT

Nutrients 2020 78 件の引用

Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled … RCT

Nutrients 2020 59 件の引用

Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation. Other

Gut microbes 2020 36 件の引用

Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with Bifidobacterium Longum … Other

Journal of clinical … 2020 31 件の引用

Probiotics for induction of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2020 14 件の引用

Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: … RCT

Nutrients 2019 114 件の引用

Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster. Other

Beneficial microbes 2019 31 件の引用

Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation. Other

Journal of neurogastroenterology … 2018 121 件の引用

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells. Other

Saudi journal of … 2018 41 件の引用

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 件の引用

The Fragility of Probiotic Bifidobacterium longum NCC3001 Use for Depression in Patients With Irritable Bowel Syndrome. Other

Gastroenterology 2018 23 件の引用

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. RCT

Gastroenterology 2017 684 件の引用

A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. RCT

The Australian and … 2017 280 件の引用

Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis. Meta-Analysis

Current medical research … 2017 86 件の引用

When the low FODMAP diet does not work. Review

Journal of gastroenterology … 2017 32 件の引用

Bifidobacterium infantis 35624 and other probiotics in the management of irritable bowel syndrome. Strain specificity, symptoms, and mechanisms. Other

Current medical research … 2017 21 件の引用

Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp. longum 35624™. Other

PloS one 2016 83 件の引用

Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome. Other

Artificial cells, nanomedicine, … 2016 16 件の引用

Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. RCT

Journal of gastroenterology … 2014 164 件の引用

[Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind … Review

Orvosi hetilap 2014 6 件の引用

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 件の引用

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 件の引用

Role of gut microflora and probiotic effects in the irritable bowel syndrome. RCT

Acta bio-medica : … 2006 41 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1-10 billion CFU/day
ibssupport:: 1 billion CFU/day (35624 strain, marketed as Alflorex/Align)

上限量： Well-tolerated up to 10 billion CFU/day in clinical trials

研究で検討された用量

用量	期間	効果	N
None	--	Positive	3154
None	--	Positive	--
1e6 CFU/mL	--	Positive	35
None	--	Positive	--
None	12 weeks	Positive	51
None	8 weeks	Positive	37
1x10^10 CFU daily	6 weeks	Positive	35
2 g	4 weeks	Mixed	--

推奨摂取タイミング： On an empty stomach or before meals

Safety & Side Effects

報告されている副作用

⚠ Mild gas and bloating during initial use
⚠ Occasional abdominal discomfort
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

既知の相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

耐容上限摂取量： Well-tolerated up to 10 billion CFU/day in clinical trials

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Bifidobacterium longum help with Irritable Bowel Syndrome (IBS)?

Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium longum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Bifidobacterium longum should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium longum?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium longum and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Irritable Bowel Syndrome (IBS)

Peppermint Oil A Psyllium Husk B Lactobacillus rhamnosus GG B Partially Hydrolyzed Guar Gum (PHGG) B Lactobacillus plantarum B Galactooligosaccharides (GOS) B

総合評価

RCTs demonstrate significant reduction in IBS composite symptom score versus placebo. Particular benefit for bloating and abdominal distension. Marketed as Alflorex/Align.

Evidence Strength72%

High confidence

研究の内訳

RCT (16)Meta (4)Other (0)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Irritable Bowel Syndrome (IBS)

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。