Omega-3 Fatty Acids (EPA/DHA) per Ulcerative Colitis (UC)
C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'gutcited.com';
const params = 'ingredient\u003Domega\u002D3\u002Dfatty\u002Dacids\u0026condition\u003Dibd\u002Dulcerative\u002Dcolitis';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
In sintesi
Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
Key Study Findings
Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: patients with ulcerative colitis
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
vs: None
Outcome: IBD microbiota modulation and immune regulation
Effetto: None
None
Popolazione: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
Effetto: None
None
Popolazione: Vegan athletes (narrative review)
Review
From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel …
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Diet-genetics interaction in IBD
Effetto: None
None
Popolazione: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
Effetto: None
None
Popolazione: Crohn's disease patients
Key Statistics
8
Studi
1000
Partecipanti
↔
Mixed
C
Grado
Referenced Papers
Digestive diseases and …
2026
1 citazioni
Nutrients
2025
9 citazioni
Semergen
2025
4 citazioni
Current nutrition reports
2025
3 citazioni
Autoimmunity reviews
2024
12 citazioni
World journal of …
2024
Metabolites
2023
13 citazioni
Association between dietary acid load and the odds of ulcerative colitis: a case-control study.
Other
Scientific reports
2023
1 citazioni
Nutrients
2022
66 citazioni
Nutrients
2022
61 citazioni
Journal of medicinal …
2022
8 citazioni
Foods (Basel, Switzerland)
2021
96 citazioni
Nutrients
2021
27 citazioni
Scientific reports
2020
56 citazioni
Therapeutic advances in …
2020
21 citazioni
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 citazioni
Nutrients
2019
24 citazioni
Gastroenterology clinics of …
2018
67 citazioni
International journal of …
2017
143 citazioni
Medical principles and …
2017
45 citazioni
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
80 citazioni
European journal of …
2016
79 citazioni
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 citazioni
Clinics in dermatology
2016
19 citazioni
World journal of …
2014
36 citazioni
World journal of …
2014
25 citazioni
Alimentary pharmacology & …
2013
128 citazioni
Nutritional modulators of ulcerative colitis: clinical efficacies and mechanistic view.
Systematic Review
World journal of …
2013
56 citazioni
The British journal …
2012
145 citazioni
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 citazioni
World journal of …
2012
113 citazioni
Frontline gastroenterology
2012
20 citazioni
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
The American journal …
2011
946 citazioni
Inflammatory bowel diseases
2011
195 citazioni
Nutrition in clinical …
2011
1 citazioni
JRSM short reports
2010
11 citazioni
Inflammatory bowel diseases
2008
77 citazioni
The Cochrane database …
2007
118 citazioni
Journal of food …
2007
49 citazioni
Nutrition (Burbank, Los …
2003
189 citazioni
Nutricion hospitalaria
2003
Journal of the …
2002
2016 citazioni
Nutrition (Burbank, Los …
2000
64 citazioni
Drugs
1998
99 citazioni
The American journal …
1998
84 citazioni
Bailliere's clinical gastroenterology
1997
26 citazioni
Langenbecks Archiv fur …
1995
3 citazioni
The American journal …
1992
260 citazioni
The American journal …
1991
2278 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
Limite massimo: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| 95% | -- | Mixed | 124 |
Momento migliore per l'assunzione: With meals containing fat for better absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
Interazioni note
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
Livello di assunzione massimo tollerabile: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Ulcerative Colitis (UC)?
Based on 8 studies with 1,000 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Ulcerative Colitis (UC) management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Ulcerative Colitis (UC)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 1,000 total participants. The overall direction of effect is mixed.
Related Evidence
Altri ingredienti per Ulcerative Colitis (UC)
Omega-3 Fatty Acids (EPA/DHA) per altre condizioni
References
- [1] Fares Jamal et al.. Dig Dis Sci. 2026. Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment. doi:10.1007/s10620-025-09387-z PubMed
- [2] Riya Gautam Naik et al.. Nutrients. 2025. From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel Disease Management. doi:10.3390/nu17030470 PubMed
- [3] D Fetarayani et al.. Semergen. 2025. Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit. doi:10.1016/j.semerg.2025.102575 PubMed
- [4] Álvaro Vergara A Nieto et al.. Curr Nutr Rep. 2025. Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. doi:10.1007/s13668-025-00633-4 PubMed
- [5] Kimsor Hong et al.. Autoimmun Rev. 2024. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. doi:10.1016/j.autrev.2024.103651 PubMed
- [6] Daniéla Oliveira Magro et al.. World J Gastroenterol. 2024. Interaction between diet and genetics in patients with inflammatory bowel disease. doi:10.3748/wjg.v30.i12.1644 PubMed
- [7] Xiaojing Jia et al.. Metabolites. 2023. Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study. doi:10.3390/metabo13101041 PubMed
- [8] Mina Movahedian et al.. Sci Rep. 2023. Association between dietary acid load and the odds of ulcerative colitis: a case-control study. doi:10.1038/s41598-023-41069-6 PubMed
- [9] Ammar Hassanzadeh Keshteli et al.. Nutrients. 2022. Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission. doi:10.3390/nu14163294 PubMed
- [10] Marcelina Radziszewska et al.. Nutrients. 2022. Nutrition and Supplementation in Ulcerative Colitis. doi:10.3390/nu14122469 PubMed
- [11] Verônica Assalin Zorgetto-Pinheiro et al.. J Med Food. 2022. Omega-3 Fatty Acids and Balanced Gut Microbiota on Chronic Inflammatory Diseases: A Close Look at Ulcerative Colitis and Rheumatoid Arthritis … doi:10.1089/jmf.2021.0012 PubMed
- [12] Vishnu Kalladathvalappil Venugopalan et al.. Foods. 2021. Encapsulation and Protection of Omega-3-Rich Fish Oils Using Food-Grade Delivery Systems. doi:10.3390/foods10071566 PubMed
- [13] Jean-Frédéric LeBlanc et al.. Nutrients. 2021. The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis. doi:10.3390/nu13061780 PubMed
- [14] Robert Carreras-Torres et al.. Sci Rep. 2020. Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study. doi:10.1038/s41598-020-76361-2 PubMed
- [15] Sherman Picardo et al.. Therap Adv Gastroenterol. 2020. Complementary and alternative medications in the management of inflammatory bowel disease. doi:10.1177/1756284820927550 PubMed
- [16] Mohita Sharma et al.. Toxicol Mech Methods. 2019. Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. doi:10.1080/15376516.2018.1553220 PubMed
- [17] Masako Nakanishi et al.. Nutrients. 2019. Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration. doi:10.3390/nu11051118 PubMed
- [18] Berkeley N Limketkai et al.. Gastroenterol Clin North Am. 2018. Nutritional Interventions in the Patient with Inflammatory Bowel Disease. doi:10.1016/j.gtc.2017.09.007 PubMed
- [19] Eleonora Scaioli et al.. Int J Mol Sci. 2017. The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives. doi:10.3390/ijms18122619 PubMed
- [20] Islam Khan et al.. Med Princ Pract. 2017. Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal. doi:10.1159/000468988 PubMed
- [21] Christian Lodberg Hvas et al.. Ugeskr Laeger. 2017. [Nutrition and dietary supplement in chronic inflammatory bowel diesease]. PubMed
- [22] Sandra Maria Barbalho et al.. Ann Gastroenterol. 2016. Inflammatory bowel disease: can omega-3 fatty acids really help? PubMed
- [23] Raquel Cristina Schwanke et al.. Eur J Pharmacol. 2016. EPA- and DHA-derived resolvins' actions in inflammatory bowel disease. doi:10.1016/j.ejphar.2015.08.050 PubMed
- [24] Alyssa Parian et al.. Curr Pharm Des. 2016. Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. doi:10.2174/1381612822666151112145033 PubMed
- [25] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [26] Suneela S Dhaneshwar. World J Gastroenterol. 2014. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. doi:10.3748/wjg.v20.i13.3564 PubMed
- [27] Affifa Farrukh et al.. World J Clin Cases. 2014. Is there a role for fish oil in inflammatory bowel disease? doi:10.12998/wjcc.v2.i7.250 PubMed
- [28] S C Ng et al.. Aliment Pharmacol Ther. 2013. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. doi:10.1111/apt.12464 PubMed
- [29] Mi-Kyung Sung et al.. World J Gastroenterol. 2013. Nutritional modulators of ulcerative colitis: clinical efficacies and mechanistic view. doi:10.3748/wjg.v19.i7.994 PubMed
- [30] Eduard Cabré et al.. Br J Nutr. 2012. Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. doi:10.1017/S0007114512001626 PubMed
- [31] Fiona J Bath-Hextall et al.. Cochrane Database Syst Rev. 2012. Dietary supplements for established atopic eczema. doi:10.1002/14651858.CD005205.pub3 PubMed
- [32] Eduard Cabré et al.. World J Gastroenterol. 2012. Impact of environmental and dietary factors on the course of inflammatory bowel disease. doi:10.3748/wjg.v18.i29.3814 PubMed
- [33] Melissa A Smith et al.. Frontline Gastroenterol. 2012. Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. doi:10.1136/flgastro-2011-100032 PubMed
- [34] Jason K Hou et al.. Am J Gastroenterol. 2011. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. doi:10.1038/ajg.2011.44 PubMed
- [35] Dan Turner et al.. Inflamm Bowel Dis. 2011. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. doi:10.1002/ibd.21374 PubMed
- [36] Gerard E Mullin. Nutr Clin Pract. 2011. Comment On: Maintenance of Remission in Inflammatory Bowel Disease Using Omega-3 Fatty Acids (Fish Oil): A Systematic Review and Meta-Analyses. doi:10.1177/0884533611400087 PubMed
- [37] Cinzia Papadia et al.. JRSM Short Rep. 2010. Omega-3 fatty acids in the maintenance of ulcerative colitis. doi:10.1258/shorts.2010.010004 PubMed
- [38] Hisayuki Matsunaga et al.. Inflamm Bowel Dis. 2008. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. doi:10.1002/ibd.20491 PubMed
- [39] D Turner et al.. Cochrane Database Syst Rev. 2007. Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. doi:10.1002/14651858.CD006443.pub2 PubMed
- [40] R Borneo et al.. J Food Sci. 2007. Stability and consumer acceptance of long-chain omega-3 fatty acids (eicosapentaenoic acid, 20:5, n-3 and docosahexaenoic acid, 22:6, n-3) in cream-filled … doi:10.1111/j.1750-3841.2006.00240.x PubMed
- [41] Décio Sabbatini Barbosa et al.. Nutrition. 2003. Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. doi:10.1016/s0899-9007(03)00162-x PubMed
- [42] F G Campos et al.. Nutr Hosp. 2003. Pharmacological nutrition in inflammatory bowel diseases. PubMed
- [43] Artemis P Simopoulos. J Am Coll Nutr. 2002. Omega-3 fatty acids in inflammation and autoimmune diseases. doi:10.1080/07315724.2002.10719248 PubMed
- [44] I Dichi et al.. Nutrition. 2000. Comparison of omega-3 fatty acids and sulfasalazine in ulcerative colitis. doi:10.1016/s0899-9007(99)00231-2 PubMed
- [45] A Heller et al.. Drugs. 1998. Lipid mediators in inflammatory disorders. doi:10.2165/00003495-199855040-00001 PubMed
- [46] Y Z Almallah et al.. Am J Gastroenterol. 1998. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. doi:10.1111/j.1572-0241.1998.229_a.x PubMed
- [47] A Burke et al.. Baillieres Clin Gastroenterol. 1997. Nutrition and ulcerative colitis. doi:10.1016/s0950-3528(97)90059-2 PubMed
- [48] M Bartels et al.. Langenbecks Arch Chir. 1995. [What is the role of nutrition in ulcerative colitis? A contribution to the current status of diet therapy in treatment … doi:10.1007/BF00184410 PubMed
- [49] A Aslan et al.. Am J Gastroenterol. 1992. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. PubMed
- [50] A P Simopoulos. Am J Clin Nutr. 1991. Omega-3 fatty acids in health and disease and in growth and development. doi:10.1093/ajcn/54.3.438 PubMed
Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.