Omega-3 Fatty Acids (EPA/DHA) untuk Ulcerative Colitis (UC)

Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.

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Kesimpulan

Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.

Key Study Findings

Review

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.

Dose: None vs: None Outcome: None Efek: None None

Populasi: patients with ulcerative colitis

Review

Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.

Dose: None vs: None Outcome: IBD microbiota modulation and immune regulation Efek: None None

Populasi: IBD patients (review of nutritional interventions)

Review

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.

Dose: None vs: None Outcome: Athletic performance and nutritional optimization Efek: None None

Populasi: Vegan athletes (narrative review)

Review

From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel …

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Other

Interaction between diet and genetics in patients with inflammatory bowel disease.

Dose: None vs: None Outcome: Diet-genetics interaction in IBD Efek: None None

Populasi: IBD patients (editorial commentary)

Review

Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …

Dose: None vs: None Outcome: Colitis severity Efek: None None

Populasi: Crohn's disease patients

Key Statistics

Studi

1000

Peserta

↔

Mixed

Peringkat

Referenced Papers

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment. Review

Digestive diseases and … 2026 1 sitasi

From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel Disease Management. Review

Nutrients 2025 9 sitasi

Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit. Review

Semergen 2025 4 sitasi

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 sitasi

Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Review

Autoimmunity reviews 2024 12 sitasi

Interaction between diet and genetics in patients with inflammatory bowel disease. Other

World journal of … 2024

Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study. Other

Metabolites 2023 13 sitasi

Association between dietary acid load and the odds of ulcerative colitis: a case-control study. Other

Scientific reports 2023 1 sitasi

Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission. RCT

Nutrients 2022 66 sitasi

Nutrition and Supplementation in Ulcerative Colitis. Review

Nutrients 2022 61 sitasi

Omega-3 Fatty Acids and Balanced Gut Microbiota on Chronic Inflammatory Diseases: A Close Look at Ulcerative Colitis and Rheumatoid Arthritis … Review

Journal of medicinal … 2022 8 sitasi

Encapsulation and Protection of Omega-3-Rich Fish Oils Using Food-Grade Delivery Systems. Review

Foods (Basel, Switzerland) 2021 96 sitasi

The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis. Review

Nutrients 2021 27 sitasi

Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study. Other

Scientific reports 2020 56 sitasi

Complementary and alternative medications in the management of inflammatory bowel disease. Review

Therapeutic advances in … 2020 21 sitasi

Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. Other

Toxicology mechanisms and … 2019 33 sitasi

Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration. Other

Nutrients 2019 24 sitasi

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 sitasi

The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives. Review

International journal of … 2017 143 sitasi

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal. Other

Medical principles and … 2017 45 sitasi

[Nutrition and dietary supplement in chronic inflammatory bowel diesease]. Review

Ugeskrift for laeger 2017

Inflammatory bowel disease: can omega-3 fatty acids really help? Review

Annals of gastroenterology 2016 80 sitasi

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease. Review

European journal of … 2016 79 sitasi

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 sitasi

Nutrition and skin: Kids are not just little people. Review

Clinics in dermatology 2016 19 sitasi

Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. Review

World journal of … 2014 36 sitasi

Is there a role for fish oil in inflammatory bowel disease? Review

World journal of … 2014 25 sitasi

Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Systematic Review

Alimentary pharmacology & … 2013 128 sitasi

Nutritional modulators of ulcerative colitis: clinical efficacies and mechanistic view. Systematic Review

World journal of … 2013 56 sitasi

Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Systematic Review

The British journal … 2012 145 sitasi

Dietary supplements for established atopic eczema. Meta-Analysis

The Cochrane database … 2012 130 sitasi

Impact of environmental and dietary factors on the course of inflammatory bowel disease. Review

World journal of … 2012 113 sitasi

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 sitasi

Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Systematic Review

The American journal … 2011 946 sitasi

Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Meta-Analysis

Inflammatory bowel diseases 2011 195 sitasi

Comment On: Maintenance of Remission in Inflammatory Bowel Disease Using Omega-3 Fatty Acids (Fish Oil): A Systematic Review and Meta-Analyses. Other

Nutrition in clinical … 2011 1 sitasi

Omega-3 fatty acids in the maintenance of ulcerative colitis. Case Report

JRSM short reports 2010 11 sitasi

Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Other

Inflammatory bowel diseases 2008 77 sitasi

Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. Meta-Analysis

The Cochrane database … 2007 118 sitasi

Stability and consumer acceptance of long-chain omega-3 fatty acids (eicosapentaenoic acid, 20:5, n-3 and docosahexaenoic acid, 22:6, n-3) in cream-filled … Other

Journal of food … 2007 49 sitasi

Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. RCT

Nutrition (Burbank, Los … 2003 189 sitasi

Pharmacological nutrition in inflammatory bowel diseases. Other

Nutricion hospitalaria 2003

Omega-3 fatty acids in inflammation and autoimmune diseases. Review

Journal of the … 2002 2016 sitasi

Comparison of omega-3 fatty acids and sulfasalazine in ulcerative colitis. RCT

Nutrition (Burbank, Los … 2000 64 sitasi

Lipid mediators in inflammatory disorders. Review

Drugs 1998 99 sitasi

Distal procto-colitis, natural cytotoxicity, and essential fatty acids. RCT

The American journal … 1998 84 sitasi

Nutrition and ulcerative colitis. Review

Bailliere's clinical gastroenterology 1997 26 sitasi

[What is the role of nutrition in ulcerative colitis? A contribution to the current status of diet therapy in treatment … Review

Langenbecks Archiv fur … 1995 3 sitasi

Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. RCT

The American journal … 1992 260 sitasi

Omega-3 fatty acids in health and disease and in growth and development. Review

The American journal … 1991 2278 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 1,000-2,000 mg combined EPA/DHA per day
ibdsupport:: 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)

Batas atas: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
None	--	Neutral	--
95%	--	Mixed	--
95%	--	Mixed	124

Waktu terbaik diminum: With meals containing fat for better absorption

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Fishy aftertaste and burping
⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
⚠ Potential increased bleeding time at very high doses (>3 g/day)
⚠ May lower blood pressure slightly

Interaksi yang Diketahui

● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (may reduce omega-3 absorption)
● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)

Asupan atas yang dapat ditoleransi: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Omega-3 Fatty Acids (EPA/DHA) help with Ulcerative Colitis (UC)?

Based on 8 studies with 1,000 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Ulcerative Colitis (UC) management. Our evidence grade is C (Some Evidence).

How much Omega-3 Fatty Acids (EPA/DHA) should I take for Ulcerative Colitis (UC)?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?

Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Ulcerative Colitis (UC)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 1,000 total participants. The overall direction of effect is mixed.

Related Evidence

Bahan lain untuk Ulcerative Colitis (UC)

Curcumin B Butyrate (Sodium/Calcium Butyrate) C Resistant Starch D Aloe Vera (Inner Leaf Gel) D

Omega-3 Fatty Acids (EPA/DHA) untuk kondisi lain

Crohn's Disease C

Kesimpulan Singkat

Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (5)Meta (3)Other (0)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Ulcerative Colitis (UC)

Pelajari Lebih Lanjut

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