Omega-3 Fatty Acids (EPA/DHA) لـ Ulcerative Colitis (UC)
CMixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
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C
الخلاصة
Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
Key Study Findings
Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: patients with ulcerative colitis
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
مقابل: None
Outcome: IBD microbiota modulation and immune regulation
التأثير: None
None
المجتمع المدروس: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
مقابل: None
Outcome: Athletic performance and nutritional optimization
التأثير: None
None
المجتمع المدروس: Vegan athletes (narrative review)
Review
From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
مقابل: None
Outcome: Diet-genetics interaction in IBD
التأثير: None
None
المجتمع المدروس: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
مقابل: None
Outcome: Colitis severity
التأثير: None
None
المجتمع المدروس: Crohn's disease patients
Key Statistics
8
الدراسات
1000
المشاركون
↔
Mixed
C
التقييم
Referenced Papers
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Association between dietary acid load and the odds of ulcerative colitis: a case-control study.
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21 اقتباسات
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
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33 اقتباسات
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24 اقتباسات
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2018
67 اقتباسات
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80 اقتباسات
European journal of …
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79 اقتباسات
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
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36 اقتباسات
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2014
25 اقتباسات
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Systematic Review
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2013
56 اقتباسات
The British journal …
2012
145 اقتباسات
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Meta-Analysis
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2012
130 اقتباسات
World journal of …
2012
113 اقتباسات
Frontline gastroenterology
2012
20 اقتباسات
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
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2011
946 اقتباسات
Inflammatory bowel diseases
2011
195 اقتباسات
Nutrition in clinical …
2011
1 اقتباسات
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2010
11 اقتباسات
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2008
77 اقتباسات
The Cochrane database …
2007
118 اقتباسات
Journal of food …
2007
49 اقتباسات
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2003
189 اقتباسات
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Journal of the …
2002
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Nutrition (Burbank, Los …
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64 اقتباسات
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The American journal …
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84 اقتباسات
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Langenbecks Archiv fur …
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3 اقتباسات
The American journal …
1992
260 اقتباسات
The American journal …
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2278 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
الحد الأعلى: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| 95% | -- | Mixed | 124 |
أفضل وقت للتناول: With meals containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
التفاعلات المعروفة
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
الحد الأقصى المسموح به: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Ulcerative Colitis (UC)?
Based on 8 studies with 1,000 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Ulcerative Colitis (UC) management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Ulcerative Colitis (UC)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 1,000 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Ulcerative Colitis (UC)
Omega-3 Fatty Acids (EPA/DHA) لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.