Omega-3 Fatty Acids (EPA/DHA) لـ Ulcerative Colitis (UC)
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
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C
الخلاصة
Mixed results in maintaining UC remission. Some meta-analyses show modest benefit; others show no significant effect. EPA may be more beneficial than DHA.
Key Study Findings
Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: patients with ulcerative colitis
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
مقابل: None
Outcome: IBD microbiota modulation and immune regulation
التأثير: None
None
المجتمع المدروس: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
مقابل: None
Outcome: Athletic performance and nutritional optimization
التأثير: None
None
المجتمع المدروس: Vegan athletes (narrative review)
Review
From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
مقابل: None
Outcome: Diet-genetics interaction in IBD
التأثير: None
None
المجتمع المدروس: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
مقابل: None
Outcome: Colitis severity
التأثير: None
None
المجتمع المدروس: Crohn's disease patients
Key Statistics
8
الدراسات
1000
المشاركون
↔
Mixed
C
التقييم
Referenced Papers
Digestive diseases and …
2026
1 اقتباسات
Nutrients
2025
9 اقتباسات
Semergen
2025
4 اقتباسات
Current nutrition reports
2025
3 اقتباسات
Autoimmunity reviews
2024
12 اقتباسات
World journal of …
2024
Metabolites
2023
13 اقتباسات
Association between dietary acid load and the odds of ulcerative colitis: a case-control study.
Other
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2023
1 اقتباسات
Nutrients
2022
66 اقتباسات
Nutrients
2022
61 اقتباسات
Journal of medicinal …
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96 اقتباسات
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2021
27 اقتباسات
Scientific reports
2020
56 اقتباسات
Therapeutic advances in …
2020
21 اقتباسات
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
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2019
33 اقتباسات
Nutrients
2019
24 اقتباسات
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Medical principles and …
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Ugeskrift for laeger
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European journal of …
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Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
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2014
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2013
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Nutritional modulators of ulcerative colitis: clinical efficacies and mechanistic view.
Systematic Review
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The British journal …
2012
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Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 اقتباسات
World journal of …
2012
113 اقتباسات
Frontline gastroenterology
2012
20 اقتباسات
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
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2011
946 اقتباسات
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195 اقتباسات
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1 اقتباسات
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The Cochrane database …
2007
118 اقتباسات
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Nutrition (Burbank, Los …
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Nutricion hospitalaria
2003
Journal of the …
2002
2016 اقتباسات
Nutrition (Burbank, Los …
2000
64 اقتباسات
Drugs
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99 اقتباسات
The American journal …
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84 اقتباسات
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1997
26 اقتباسات
Langenbecks Archiv fur …
1995
3 اقتباسات
The American journal …
1992
260 اقتباسات
The American journal …
1991
2278 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
الحد الأعلى: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| 95% | -- | Mixed | 124 |
أفضل وقت للتناول: With meals containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
التفاعلات المعروفة
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
الحد الأقصى المسموح به: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Ulcerative Colitis (UC)?
Based on 8 studies with 1,000 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Ulcerative Colitis (UC) management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Ulcerative Colitis (UC)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 1,000 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Ulcerative Colitis (UC)
Omega-3 Fatty Acids (EPA/DHA) لحالات أخرى
References
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