Alpha-Galactosidase untuk Irritable Bowel Syndrome (IBS)

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

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Kesimpulan

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G vs: placebo Outcome: every 30 min during 7 Efek: None None

Populasi: patients with ibs after three standardized

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU vs: Placebo (glucose) Outcome: GI symptom severity on VAS Efek: None pP0.006

Populasi: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal vs: placebo Outcome: overall IBS symptom relief Efek: no significant difference vs placebo >0.05

Populasi: IBS patients

Key Statistics

Studi

Peserta

↑

Positive

Peringkat

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 sitasi

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 sitasi

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 sitasi

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

Batas atas: No established upper limit; adjust per meal as needed

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
1200 G	--	Neutral	--
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125

Waktu terbaik diminum: With the first bite of gas-producing food

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

Interaksi yang Diketahui

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

Asupan atas yang dapat ditoleransi: No established upper limit; adjust per meal as needed

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Alpha-Galactosidase help with Irritable Bowel Syndrome (IBS)?

Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that Alpha-Galactosidase may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Alpha-Galactosidase should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Alpha-Galactosidase untuk kondisi lain

Bloating and Intestinal Gas B

Kesimpulan Singkat

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Evidence Strength30%

Low confidence

Rincian Studi

RCT (3)Meta (0)Other (0)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Irritable Bowel Syndrome (IBS)

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.