Curcumin के लिए Ulcerative Colitis (UC)

Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.

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निष्कर्ष

Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.

Key Study Findings

Systematic Review

The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.

Dose: None बनाम: placebo or standard therapy Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs) प्रभाव: None None

जनसंख्या: patients with ulcerative colitis

Other

Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.

Dose: None बनाम: untreated colitis controls Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, … प्रभाव: None None

जनसंख्या: UC animal model and oxidatively stressed colon cells

Review

Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

Systematic Review

Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.

Dose: None बनाम: Various comparators Outcome: Multiple health outcomes प्रभाव: None None

जनसंख्या: Human subjects across 25 meta-analyses

Review

Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

In Vitro

Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.

Dose: None बनाम: DSS-induced UC mice Outcome: UC inflammation via SphK1/NF-kB pathway प्रभाव: None None

जनसंख्या: DSS-induced UC murine model

Key Statistics

अध्ययन

400

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review. Systematic Review

Nutrition reviews 2026

Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis. Other

ACS nano 2025 29 उद्धरण

Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway. Review

Frontiers in immunology 2025 20 उद्धरण

Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis. Review

Naunyn-Schmiedeberg's archives of … 2025 14 उद्धरण

Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses. Systematic Review

Frontiers in pharmacology 2025 10 उद्धरण

Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway. Other

BioFactors (Oxford, England) 2025 9 उद्धरण

Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials. Systematic Review

Frontiers in nutrition 2025 8 उद्धरण

Curcumin-loaded zein and shellac composite nanoparticles for ulcerative colitis treatment. Other

European journal of … 2025 7 उद्धरण

Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled … Meta-Analysis

Explore (New York, … 2025 5 उद्धरण

Eliminating ROS and Alleviating Inflammation to Restore the Integrity of Intestinal Epithelium in DSS-Induced Ulcerative Colitis by a pH-Responsive Delivery … Other

Journal of agricultural … 2025 3 उद्धरण

Ultrafast in situ formed robust and adhesive photo-crosslinked hydrogel encapsulating curcumin for ulcerative colitis alleviation via regulating inflammation and gut … Other

Materials today. Bio 2025 3 उद्धरण

Oral administration of curcumin and quercetin nanoparticles can improve ulcerative colitis by regulating intestinal microorganisms. Other

Frontiers in nutrition 2025 2 उद्धरण

Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration, and gut … Other

Frontiers in pharmacology 2025 1 उद्धरण

m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy. Other

Cellular and molecular … 2025

Curcumin Combined with Tryptophan Ameliorates DSS-Induced Ulcerative Colitis via Reducing Inflammation and Oxidative Stress and Regulation of Gut Microbiota. Other

Nutrients 2025

The Construction Strategy of Curcumin Nanomedicine Delivery System and Its Application in the Treatment of Ulcerative Colitis. Review

International journal of … 2025

Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial. RCT

Clinical gastroenterology and … 2024 52 उद्धरण

Improving curcumin bioavailability: Targeted delivery of curcumin and loading systems in intestinal inflammation. Review

Food research international … 2024 44 उद्धरण

Extracellular Vesicles from Nanomedicine-Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis. Other

Advanced materials (Deerfield … 2024 37 उद्धरण

Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity. Other

Journal of pharmaceutical … 2024 29 उद्धरण

Curcumin-loaded polysaccharide microparticles alleviated DSS-induced ulcerative colitis by improving intestinal microecology and regulating MAPK/NF-κB/Nrf2/NLRP3 pathways. Other

International journal of … 2024 27 उद्धरण

Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial. RCT

Nutrients 2024 23 उद्धरण

Curcumin-Encapsulated Co-ZIF-8 for Ulcerative Colitis Therapy: ROS Scavenging and Macrophage Modulation Effects. Other

ACS omega 2024 16 उद्धरण

The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study. Other

Frontiers in pediatrics 2024 4 उद्धरण

[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review]. Systematic Review

Zeitschrift fur Gastroenterologie 2024 3 उद्धरण

Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease. Other

World journal of … 2024

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease. Review

Frontiers in endocrinology 2023 253 उद्धरण

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects. Review

Metabolites 2023 134 उद्धरण

A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment. Other

Advanced science (Weinheim, … 2023 90 उद्धरण

"Dual sensitive supramolecular curcumin nanoparticles" in "advanced yeast particles" mediate macrophage reprogramming, ROS scavenging and inflammation resolution for ulcerative colitis … Other

Journal of nanobiotechnology 2023 63 उद्धरण

Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease. Review

Pharmaceuticals (Basel, Switzerland) 2023 18 उद्धरण

Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model. Other

Toxicology mechanisms and … 2023 5 उद्धरण

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy. Other

Journal of nanobiotechnology 2022 206 उद्धरण

The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation. Review

International journal of … 2022 142 उद्धरण

Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations. Review

The American journal … 2022 86 उद्धरण

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of … Meta-Analysis

Frontiers in immunology 2022 68 उद्धरण

Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis. Meta-Analysis

Journal of ethnopharmacology 2022 39 उद्धरण

Ulcerative Colitis: Rapid Evidence Review. Review

American family physician 2022 38 उद्धरण

Old but Fancy: Curcumin in Ulcerative Colitis-Current Overview. Review

Nutrients 2022 19 उद्धरण

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. Review

Turkish journal of … 2022 3 उद्धरण

Turmeric and Curcumin: From Traditional to Modern Medicine. Other

Advances in experimental … 2021 87 उद्धरण

Gastroprotective Effects of Polyphenols against Various Gastro-Intestinal Disorders: A Mini-Review with Special Focus on Clinical Evidence. Review

Molecules (Basel, Switzerland) 2021 85 उद्धरण

Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review. Meta-Analysis

Journal of medicinal … 2021 52 उद्धरण

Diet supporting therapy for inflammatory bowel diseases. Review

European journal of … 2021 40 उद्धरण

Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis. Meta-Analysis

Complementary therapies in … 2021 30 उद्धरण

A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases. Systematic Review

Advances in experimental … 2021 8 उद्धरण

Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn's Disease After Surgery in a Randomized Controlled Trial. RCT

Clinical gastroenterology and … 2020 49 उद्धरण

The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials. Systematic Review

Nutrients 2020 48 उद्धरण

The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease-A Review. Review

Nutrients 2020 30 उद्धरण

Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials. Meta-Analysis

Journal of gastroenterology … 2020 30 उद्धरण

Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis. Meta-Analysis

Expert review of … 2020 25 उद्धरण

Complementary and alternative medications in the management of inflammatory bowel disease. Review

Therapeutic advances in … 2020 21 उद्धरण

The effectiveness and safety of curcumin as a complementary therapy in inflammatory bowel disease: A protocol of systematic review and … Other

Medicine 2020 4 उद्धरण

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Review

International journal of … 2019 137 उद्धरण

Curcumin in Autoimmune and Rheumatic Diseases. Review

Nutrients 2019 71 उद्धरण

Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis? Review

Critical reviews in … 2019 48 उद्धरण

Dietary Management of Pediatric Inflammatory Bowel Disease. Review

Journal of medicinal … 2019 17 उद्धरण

Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis. Review

Immunopharmacology and immunotoxicology 2018 96 उद्धरण

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 उद्धरण

Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Meta-Analysis

Nutrients 2018 46 उद्धरण

Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis. Meta-Analysis

The American journal … 2018 30 उद्धरण

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal. Other

Medical principles and … 2017 45 उद्धरण

Efficacy of Curcumin as Adjuvant Therapy to Induce or Maintain Remission in Ulcerative Colitis Patients: an Evidence-based Clinical Review. Meta-Analysis

Acta medica Indonesiana 2017 24 उद्धरण

Complementary and Integrative Gastroenterology. Review

The Medical clinics … 2017 9 उद्धरण

[Nutrition and dietary supplement in chronic inflammatory bowel diesease]. Review

Ugeskrift for laeger 2017

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 उद्धरण

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 उद्धरण

Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. Systematic Review

Journal of Crohn's … 2015 184 उद्धरण

Herbal and plant therapy in patients with inflammatory bowel disease. Review

Annals of gastroenterology 2015 135 उद्धरण

Curcumin and inflammatory bowel disease: potential and limits of innovative treatments. Review

Molecules (Basel, Switzerland) 2014 122 उद्धरण

Advances in treatment of ulcerative colitis with herbs: from bench to bedside. Review

World journal of … 2014 23 उद्धरण

Therapeutic roles of curcumin: lessons learned from clinical trials. Review

The AAPS journal 2013 1866 उद्धरण

Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Systematic Review

Alimentary pharmacology & … 2013 128 उद्धरण

Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study. Other

Journal of pediatric … 2013 103 उद्धरण

Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations. Review

Food & function 2012 151 उद्धरण

[Current concepts about the treatment of inflammatory bowel disease, biological therapy]. Review

Revista de gastroenterologia … 2008 2 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 500-1,500 mg/day with piperine (black pepper extract) for absorption
ibssupport:: 500-1,000 mg/day
ucmaintenance:: 2,000 mg/day (1 g twice daily) as adjunct to mesalamine

अधिकतम सीमा: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
Varying dosages	--	Positive	--
None	--	Positive	--

सेवन का सर्वोत्तम समय: With meals containing fat and black pepper for enhanced absorption

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
⚠ Yellow staining of skin/teeth with topical/oral contact
⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
⚠ Iron chelation (may reduce iron absorption at very high doses)

ज्ञात अंतःक्रियाएँ

● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
● Iron supplements (curcumin may chelate iron; space dosing)
● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)

सहनीय अधिकतम सेवन: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Curcumin help with Ulcerative Colitis (UC)?

Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).

How much Curcumin should I take for Ulcerative Colitis (UC)?

Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Curcumin?

Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री Ulcerative Colitis (UC)

Omega-3 Fatty Acids (EPA/DHA) C Butyrate (Sodium/Calcium Butyrate) C Resistant Starch D Aloe Vera (Inner Leaf Gel) D

Curcumin अन्य स्वास्थ्य स्थितियों के लिए

Crohn's Disease C Irritable Bowel Syndrome (IBS) C

संक्षिप्त निष्कर्ष

Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.

Evidence Strength72%

High confidence

अध्ययन विश्लेषण

RCT (3)Meta (10)Other (0)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Ulcerative Colitis (UC)

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।