Lactobacillus acidophilus لـ Irritable Bowel Syndrome (IBS)

Q: Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

Q: How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

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الخلاصة

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Key Study Findings

Randomized Controlled Trial n=200 12 weeks Double-blind

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable …

Dose: None مقابل: placebo Outcome: IBS-Global Improvement Scale response التأثير: 19.3% vs 8.9% response at day 28 p=0.048

المجتمع المدروس: adults with non-constipated irritable bowel syndrome

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None مقابل: placebo Outcome: quality of life, depression, and anxiety in IBS … التأثير: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

المجتمع المدروس: patients with irritable bowel syndrome

Randomized Controlled Trial n=61 12 weeks Double-blind

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …

Dose: None مقابل: Placebo Outcome: IBS-SSS (100-point reduction) التأثير: 45% active vs 33% placebo (P=0.42) P=0.42

المجتمع المدروس: IBD patients with IBS symptoms in remission

Randomized Controlled Trial n=110 12 weeks Double-blind

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for …

Dose: 10^9 CFU L. acidophilus LA-5 + L. paracasei daily مقابل: Placebo cultured milk Outcome: Depression risk and serotonin levels in IBS patients التأثير: None <0.001 (depression score)

المجتمع المدروس: IBS patients with normal mood and subthreshold depression

In Vitro

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …

Dose: None مقابل: None Outcome: Colitis severity التأثير: None None

المجتمع المدروس: Crohn's disease patients

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g مقابل: Placebo Outcome: Constipation symptoms التأثير: None P = 0.005

المجتمع المدروس: IBS patients

Key Statistics

الدراسات

350

المشاركون

↑

Positive

التقييم

Referenced Papers

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized … RCT

Journal of gastroenterology … 2026 1 اقتباسات

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation … Other

World journal of … 2025 2 اقتباسات

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. RCT

Scientific reports 2024 20 اقتباسات

Computational prediction of new therapeutic effects of probiotics. Other

Scientific reports 2024 10 اقتباسات

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 اقتباسات

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … Other

Journal of clinical … 2024 4 اقتباسات

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 اقتباسات

A Synbiotic Combining Chitin-Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an … Other

International journal of … 2024 2 اقتباسات

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Meta-Analysis

Nutrients 2023 33 اقتباسات

Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. Other

Anaerobe 2023 14 اقتباسات

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 اقتباسات

Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Other

Minerva pediatrics 2023 2 اقتباسات

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 اقتباسات

Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis. Systematic Review

Nutrients 2022 19 اقتباسات

Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study. Other

Gastroenterology research and … 2022 15 اقتباسات

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 اقتباسات

Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Other

Acta gastro-enterologica Belgica 2021 14 اقتباسات

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. RCT

Nutrients 2020 99 اقتباسات

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … RCT

Nutrients 2020 78 اقتباسات

A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. RCT

Digestive and liver … 2020 28 اقتباسات

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future … Review

Cellular and molecular … 2020 4 اقتباسات

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 اقتباسات

Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model. Other

BMC complementary and … 2019 24 اقتباسات

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Review

Diseases (Basel, Switzerland) 2018 50 اقتباسات

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. RCT

Beneficial microbes 2018 48 اقتباسات

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells. Other

Saudi journal of … 2018 41 اقتباسات

Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. RCT

Cellular and molecular … 2017 9 اقتباسات

Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. RCT

World journal of … 2016 99 اقتباسات

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of … RCT

Journal of dairy … 2016 67 اقتباسات

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 اقتباسات

Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. RCT

Journal of gastroenterology … 2014 164 اقتباسات

[Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind … Review

Orvosi hetilap 2014 6 اقتباسات

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 اقتباسات

Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. RCT

Scandinavian journal of … 2013 74 اقتباسات

A meta-analysis of probiotic efficacy for gastrointestinal diseases. Meta-Analysis

PloS one 2012 445 اقتباسات

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 اقتباسات

[Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome]. RCT

Revista de gastroenterologia … 2012

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 اقتباسات

Probiotics in irritable bowel syndrome: underachievers or underpowered? Other

Alimentary pharmacology & … 2010 4 اقتباسات

B-cell activation in patients with irritable bowel syndrome (IBS). Other

Neurogastroenterology and motility 2009 81 اقتباسات

Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Other

Gut and liver 2009 77 اقتباسات

Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. RCT

Digestive diseases and … 2008 160 اقتباسات

Probiotics in functional gastrointestinal disorders: what are the facts? Review

Current opinion in … 2008 68 اقتباسات

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Other

Nature medicine 2007 774 اقتباسات

Treatment of irritable bowel syndrome. A case control experience. Other

Minerva gastroenterologica e … 2006 22 اقتباسات

Bacteriotherapy using fecal flora: toying with human motions. Review

Journal of clinical … 2004 298 اقتباسات

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 اقتباسات

Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. RCT

The American journal … 1983 78 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 1-10 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
lactosesupport:: 1-2 billion CFU with dairy consumption

الحد الأعلى: Generally well-tolerated up to 20 billion CFU/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	12 weeks	Positive	200
None	--	Positive	3154
None	12 weeks	Neutral	61
10^9 CFU L. acidophilus LA-5 + L. paracasei daily	12 weeks	Positive	110
None	--	Positive	--
2 g	4 weeks	Mixed	--
Chitin-glucan + L. acidophilus NCFM	9 weeks	Positive	--
None	--	Neutral	--

أفضل وقت للتناول: On an empty stomach or before meals; may also be taken with dairy

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains)
⚠ Very rare: bacteremia in immunocompromised individuals

التفاعلات المعروفة

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Sulfasalazine (may affect bacterial metabolism)

الحد الأقصى المسموح به: Generally well-tolerated up to 20 billion CFU/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

الخلاصة السريعة

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Evidence Strength72%

High confidence

تفصيل الدراسات

RCT (17)Meta (4)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Irritable Bowel Syndrome (IBS)

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.