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GutCited

Vitamin D
Vitamin D

vitamin

别名: Cholecalciferol, Vitamin D3, Ergocalciferol, Calciferol

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About





            

                
Vitamin D plays an important role in intestinal health by binding to VDR receptors on intestinal epithelial cells, which may help enhance tight junction protein expression and support the mucosal immune response. Deficiency is common in IBD patients (up to 60%) and correlates with disease activity. Research suggests vitamin D supplementation may help reduce relapse risk in both ulcerative colitis and Crohn's disease, and support overall intestinal barrier integrity.

            

        

        

        
        
        

            

  
How It Works





            

                
Binds VDR receptors on intestinal epithelial cells enhancing tight junction protein expression (claudin-2, -12, -15); modulates mucosal immune response via regulatory T cell differentiation; induces cathelicidin antimicrobial peptide production in intestinal macrophages; deficiency associated with IBD relapse and increased intestinal permeability.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Inflammatory Bowel Disease (IBD) — General
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    1500
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Irritable Bowel Syndrome (IBS)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
                
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                    Kidney stones with excessive long-term supplementation
                
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                    Constipation
                
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                    Metallic taste
                
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Drug & Supplement Interactions





            
    
                
                
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                    Thiazide diuretics (may increase risk of hypercalcemia)
                
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                    Corticosteroids (reduce vitamin D absorption and metabolism)
                
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                    Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
                
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                    Statins (vitamin D may affect statin metabolism)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin A
                    
                
                
            

        

        
    


    
    












    

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