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GutCited

Curcumin
Curcumin

herb

别名: Turmeric Extract, Curcuma longa, Curcuminoids, Theracurmin, BCM-95, Meriva

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About





            

                
Curcumin is the primary bioactive polyphenol in turmeric (Curcuma longa) with potent anti-inflammatory properties in the GI tract. It inhibits NF-kB and COX-2 inflammatory cascades in the intestinal mucosa. The multicenter CUBE trial demonstrated that curcumin (2 g/day) alongside mesalamine may help maintain remission in ulcerative colitis, reducing relapse rates. Curcumin also supports mucosal healing and may help modulate the gut microbiome.

            

        

        

        
        
        

            

  
How It Works





            

                
Inhibits NF-kB and COX-2 inflammatory cascades in intestinal mucosa reducing pro-inflammatory cytokine production; enhances mucosal healing through TGF-beta signaling; modulates gut microbiome increasing Bifidobacteria populations; reduces intestinal oxidative stress via Nrf2 pathway activation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Ulcerative Colitis (UC)
                                    
                                
                                
                                    B

                                
                                
                                    5
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Crohn's Disease
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Irritable Bowel Syndrome (IBS)
                                    
                                
                                
                                    C

                                
                                
                                    2
                                
                                
                                    200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    GI discomfort (nausea, diarrhea, abdominal pain) at high doses
                
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                    Yellow staining of skin/teeth with topical/oral contact
                
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                    Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
                
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                    Iron chelation (may reduce iron absorption at very high doses)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
                
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                    Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
                
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                    Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
                
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                    Iron supplements (curcumin may chelate iron; space dosing)
                
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                    Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Peppermint Oil
                    
                
                
                
                    Ginger
                    
                
                
                
                    Berberine
                    
                
                
                
                    Slippery Elm
                    
                
                
                
                    Deglycyrrhizinated Licorice (DGL)
                    
                
                
            

        

        
    


    
    












    

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