Lactobacillus rhamnosus GG 用于 抗生素相关性腹泻（AAD）
A 证据 多项大型临床试验一致显示出显著的益处。荟萃分析表明LGG可将AAD发生率降低42%至49%。在抗生素开始使用后48小时内开始服用并持续至完成后7天效果最佳。
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A
结论
荟萃分析表明LGG可将AAD发生率降低42%至49%。在抗生素开始使用后48小时内开始服用并持续至完成后7天效果最佳。
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
效果: L. rhamnosus GG used by 91.8%
None
研究人群: Italian primary care pediatricians
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
效果: None
None
研究人群: Pediatric patients with GI disorders
Controlled Clinical Trial
n=24
2 weeks
Protective Effect of Probiotics on Cardiac Damage in Experimental Sepsis Model Induced by Lipopolysaccharide in …
Dose: 10^9 CFU/day for 14 days
vs: LPS-only group (no probiotics)
Outcome: Cardiac damage markers (CK-MB, cTn-I, cytokines)
效果: None
p<0.05 to <0.001
研究人群: Male Wistar albino rats with LPS-induced sepsis
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Pediatric population
Randomized Controlled Trial
Double-blind
A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea …
Dose: Probiotics (multi-strain)
vs: Placebo
Outcome: Antibiotic-associated diarrhea incidence
效果: None
None
研究人群: Adult patients receiving antibiotics
Review
Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.
Dose: S. boulardii CNCM I-745
vs: Placebo or standard care
Outcome: AAD prevention and pediatric gastroenteritis
效果: None
None
研究人群: AAD and gastroenteritis patients (review)
Key Statistics
20
研究数量
4000
受试者
↑
Positive
A
等级
Referenced Papers
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 次引用
Medicina (Kaunas, Lithuania)
2025
1 次引用
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Cureus
2024
1 次引用
Cureus
2023
19 次引用
Archivos argentinos de …
2022
23 次引用
Canadian journal of …
2022
6 次引用
International journal of …
2020
32 次引用
Pediatric gastroenterology, hepatology …
2020
20 次引用
Pharmacological research
2018
132 次引用
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.
Meta-Analysis
BMC gastroenterology
2018
80 次引用
United European gastroenterology …
2018
66 次引用
Probiotics and antimicrobial …
2018
26 次引用
World journal of …
2017
68 次引用
Journal of pediatric …
2016
233 次引用
Digestive diseases (Basel, …
2016
37 次引用
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 次引用
Journal of clinical …
2015
35 次引用
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 次引用
Nutricion hospitalaria
2015
5 次引用
Medycyna wieku rozwojowego
2012
1 次引用
Current opinion in …
2009
82 次引用
Advances in biochemical …
2008
535 次引用
The Journal of …
2007
265 次引用
The American journal …
2006
918 次引用
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 次引用
Inflammation
2002
37 次引用
The American journal …
2001
648 次引用
Inflammation
2001
101 次引用
The Journal of …
1999
559 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- aadprevention:
- 10-20 billion CFU/day (start with antibiotic, continue 7 days after)
上限： Generally well-tolerated up to 40 billion CFU/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Positive | -- |
| 10^9 CFU/day for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
| Probiotics (multi-strain) | -- | Positive | -- |
| S. boulardii CNCM I-745 | -- | Positive | -- |
| None | -- | Positive | -- |
| Twice daily | -- | Neutral | 2650 |
最佳服用时间： On an empty stomach or 30 minutes before meals for optimal survival
Safety & Side Effects
已报告的副作用
- ⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
- ⚠ Rare reports of bacteremia in severely immunocompromised individuals
- ⚠ Occasional loose stools during adjustment period
- ⚠ Very rare: systemic infection in critically ill patients with central venous catheters
已知相互作用
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
- ● Antifungals (no known interaction but may affect gut flora balance)
可耐受最高摄入量： Generally well-tolerated up to 40 billion CFU/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lactobacillus rhamnosus GG help with 抗生素相关性腹泻（AAD）?
Based on 20 studies with 4,000 participants, there is strong evidence from multiple clinical trials that Lactobacillus rhamnosus GG may support 抗生素相关性腹泻（AAD） management. Our evidence grade is A (Strong Evidence).
How much Lactobacillus rhamnosus GG should I take for 抗生素相关性腹泻（AAD）?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and 抗生素相关性腹泻（AAD）?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 4,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 抗生素相关性腹泻（AAD）
Lactobacillus rhamnosus GG 用于其他健康状况
References
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