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Deglycyrrhizinated Licorice (DGL) 用于 功能性消化不良

C 证据 来自小型研究的证据有限，但存在一些积极信号。

Traditional use supported by limited clinical data. GutGard (DGL extract) showed improvement in functional dyspepsia symptoms in small RCTs.

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            C

        

        

            
结论

            
            
Traditional use supported by limited clinical data. GutGard (DGL extract) showed improvement in functional dyspepsia symptoms in small RCTs.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: the presence of dyspepsia in the absence of organic or metabolic causes

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …
            
            

                
                Dose: Glycyrrhiza glabra flavonoid-rich extract
                
                
                vs: None
                
                
                Outcome: compatibility with probiotics and digestive enzymes
                
                
                效果: compatible with all tested strains
                
                
                None
                
            

            
            
研究人群: Probiotic strains and enzymes (in vitro)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …
            
            

                
                Dose: 75 mg twice daily
                
                
                vs: Placebo
                
                
                Outcome: Functional dyspepsia symptom severity (SFLDQ)
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: Adults with functional dyspepsia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
研究数量

    

    

        
200

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Current drug discovery …
                        2021
                        
                        16 次引用
                        
                    

                

                
                

                    

                        
                            Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of dietary …
                        2017
                        
                        13 次引用
                        
                    

                

                
                

                    

                        
                            An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Evidence-based complementary and …
                        2012
                        
                        70 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
380-760 mg DGL extract 3 times daily before meals

                    

                    
                    

                        
gastricsupport:

                        
760 mg before meals and at bedtime

                    

                    
                    

                        
dyspepsiasupport:

                        
380-400 mg chewable tablet 20 minutes before meals, 3 times daily

                    

                    
                

                
                

                    上限： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Glycyrrhiza glabra flavonoid-rich extract
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                75 mg twice daily
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild nausea in rare cases
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (uncommon)
                        
    • 
                        
                        
  • 
                            ⚠
                            If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (if residual glycyrrhizin, additive potassium loss)
                        
    • 
                        
                        
  • 
                            ●
                            Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
                        
    • 
                        
                        
  • 
                            ●
                            Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Deglycyrrhizinated Licorice (DGL) help with 功能性消化不良?
            
        
        

            Based on 3 studies with 200 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support 功能性消化不良 management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Deglycyrrhizinated Licorice (DGL) should I take for 功能性消化不良?
            
        
        

            Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Deglycyrrhizinated Licorice (DGL)?
            
        
        

            Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and 功能性消化不良?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
其他成分用于 功能性消化不良

                    

                        
                        
                            Ginger
                            B

                        
                        
                        
                            Bifidobacterium bifidum
                            C

                        
                        
                    

                

                

                
                

                    
Deglycyrrhizinated Licorice (DGL) 用于其他健康状况

                    

                        
                        
                            消化性溃疡病
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Maryam Azimi et al..
      Curr Drug Discov Technol.
      2021.
      Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
      doi:10.2174/1570163817666200611132831
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Mannanthendil Kumaran Asha et al..
      J Diet Suppl.
      2017.
      Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
      doi:10.1080/19390211.2016.1223257
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Kadur Ramamurthy Raveendra et al..
      Evid Based Complement Alternat Med.
      2012.
      An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
      doi:10.1155/2012/216970
      PubMed
    
    4. 
    
  















    

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