Curcumin для Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
Итог
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
или: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
Эффект: None
None
Популяция: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
или: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
Эффект: None
None
Популяция: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
или: Various comparators
Outcome: Multiple health outcomes
Эффект: None
None
Популяция: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
или: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
Эффект: None
None
Популяция: DSS-induced UC murine model
Key Statistics
5
Исследования
400
Участники
↑
Positive
B
Оценка
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 цитирований
Frontiers in immunology
2025
20 цитирований
Naunyn-Schmiedeberg's archives of …
2025
14 цитирований
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 цитирований
BioFactors (Oxford, England)
2025
9 цитирований
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 цитирований
European journal of …
2025
7 цитирований
Explore (New York, …
2025
5 цитирований
Journal of agricultural …
2025
3 цитирований
Materials today. Bio
2025
3 цитирований
Frontiers in nutrition
2025
2 цитирований
Frontiers in pharmacology
2025
1 цитирований
Cellular and molecular …
2025
Nutrients
2025
International journal of …
2025
Clinical gastroenterology and …
2024
52 цитирований
Food research international …
2024
44 цитирований
Advanced materials (Deerfield …
2024
37 цитирований
Journal of pharmaceutical …
2024
29 цитирований
International journal of …
2024
27 цитирований
Nutrients
2024
23 цитирований
ACS omega
2024
16 цитирований
Frontiers in pediatrics
2024
4 цитирований
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 цитирований
World journal of …
2024
Frontiers in endocrinology
2023
253 цитирований
Metabolites
2023
134 цитирований
Advanced science (Weinheim, …
2023
90 цитирований
Journal of nanobiotechnology
2023
63 цитирований
Pharmaceuticals (Basel, Switzerland)
2023
18 цитирований
Toxicology mechanisms and …
2023
5 цитирований
Journal of nanobiotechnology
2022
206 цитирований
International journal of …
2022
142 цитирований
The American journal …
2022
86 цитирований
Frontiers in immunology
2022
68 цитирований
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
Journal of ethnopharmacology
2022
39 цитирований
American family physician
2022
38 цитирований
Nutrients
2022
19 цитирований
Turkish journal of …
2022
3 цитирований
Advances in experimental …
2021
87 цитирований
Molecules (Basel, Switzerland)
2021
85 цитирований
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 цитирований
European journal of …
2021
40 цитирований
Complementary therapies in …
2021
30 цитирований
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 цитирований
Clinical gastroenterology and …
2020
49 цитирований
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 цитирований
Nutrients
2020
30 цитирований
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 цитирований
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 цитирований
Therapeutic advances in …
2020
21 цитирований
Medicine
2020
4 цитирований
International journal of …
2019
137 цитирований
Nutrients
2019
71 цитирований
Critical reviews in …
2019
48 цитирований
Journal of medicinal …
2019
17 цитирований
Immunopharmacology and immunotoxicology
2018
96 цитирований
Gastroenterology clinics of …
2018
67 цитирований
Nutrients
2018
46 цитирований
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 цитирований
Medical principles and …
2017
45 цитирований
Acta medica Indonesiana
2017
24 цитирований
The Medical clinics …
2017
9 цитирований
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 цитирований
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 цитирований
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 цитирований
Annals of gastroenterology
2015
135 цитирований
Molecules (Basel, Switzerland)
2014
122 цитирований
World journal of …
2014
23 цитирований
The AAPS journal
2013
1866 цитирований
Alimentary pharmacology & …
2013
128 цитирований
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 цитирований
Food & function
2012
151 цитирований
Revista de gastroenterologia …
2008
2 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
Верхний предел: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
Лучшее время приёма: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
Известные взаимодействия
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
Допустимый верхний уровень потребления: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
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