L-Glutamine para Crohn's Disease

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

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Conclusão

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Key Study Findings

Other

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.

Dose: None vs: None Outcome: Gut microbiota composition Efeito: None None

População: Crohn's disease patients

Controlled Clinical Trial

Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.

Dose: Washed microbiota transplantation (WMT) vs: Pre-treatment baseline Outcome: Clinical remission and multi-omics changes Efeito: None None

População: Patients with Crohn's disease

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None vs: None Outcome: Cholesterol levels Efeito: None None

População: Mouse model

Observational Study n=262

Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in …

Dose: Phenylacetylglutamine (PAGln, measured) vs: Healthy controls (n=126) Outcome: PAGln association with CD and colitis Efeito: None None

População: New-onset treatment-naive CD (n=136) + controls

In Vitro

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

Dose: Beclin1 constitutive activation (genetic) vs: Wild-type mice Outcome: Cytokine production in macrophage activation Efeito: None None

População: Beclin1 variant mice + AIEC infection

Review

[Regulation of inflammatory bowel disease by amino acids].

Dose: None vs: None Outcome: None Efeito: None None

População: IBD patients

Key Statistics

Estudos

200

Participantes

↑

Positive

Nota

Referenced Papers

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease. Other

EMBO molecular medicine 2024 13 citações

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 citações

Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study. Other

World journal of … 2024

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production. Other

Cell reports 2023 27 citações

Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Model Possibly via Platelet … Other

Journal of Crohn's … 2023 24 citações

Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease. Other

JCI insight 2022 24 citações

[Regulation of inflammatory bowel disease by amino acids]. Review

Sheng wu gong … 2022 4 citações

COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN BRAZILIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Other

Arquivos de gastroenterologia 2022 4 citações

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. Systematic Review

Clinical nutrition ESPEN 2021 39 citações

ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Other

Gastroenterology 2019 118 citações

Spontaneous colitis in IL-10-deficient mice was ameliorated via inhibiting glutaminase1. Other

Journal of cellular … 2019 23 citações

Enteral nutritional therapy for induction of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2018 425 citações

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 citações

Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. Other

Clinical medicine insights. … 2018 15 citações

Enteral Nutrition in the Management of Crohn's Disease: Reviewing Mechanisms of Actions and Highlighting Potential Venues for Enhancing the Efficacy. Review

Nutrition in clinical … 2018 10 citações

Dietary and enteral interventions for Crohn's disease. Review

Current opinion in … 2017 37 citações

Exploring and Enhancing the Anti-Inflammatory Properties of Polymeric Formula. Other

JPEN. Journal of … 2017 24 citações

Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue. Other

World journal of … 2017 21 citações

The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis. Review

The AAPS journal 2017

Glutamine for induction of remission in Crohn's disease. Systematic Review

The Cochrane database … 2016 37 citações

The role of total parenteral nutrition in inflammatory bowel disease: current aspects. Review

Scandinavian journal of … 2014 56 citações

Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. RCT

Digestive diseases and … 2012 81 citações

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 citações

Plasma citrulline concentration as a marker for disease activity in patients with Crohn's disease. Other

Journal of clinical … 2012 13 citações

Complementary, holistic, and integrative medicine: Crohn disease. Review

Pediatrics in review 2012

Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn's disease: preliminary report. Other

International journal of … 2011 12 citações

Potential for amino acids supplementation during inflammatory bowel diseases. Review

Inflammatory bowel diseases 2010 89 citações

[Impact of nutritional treatment in the evolution of inflammatory bowel disease]. Review

Nutricion hospitalaria 2010

Enteral nutrition as a primary therapy of Crohn's disease: the pediatric perspective. Review

Nutrition in clinical … 2009 36 citações

Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn's patients in association with changes in nuclear factor-kappaB … Other

The Journal of … 2008 89 citações

Enteral nutrition in adult Crohn's disease: present status and perspectives. Review

Molecular nutrition & … 2008 26 citações

Enteral nutritional therapy for induction of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2007 192 citações

Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation? Other

Digestive diseases and … 2006 73 citações

Immunonutrition. Review

Current opinion in … 2005 22 citações

The use of enteral nutrition in the management of Crohn's disease in adults. Review

JPEN. Journal of … 2005 19 citações

Glutamine metabolism in Crohn's disease: a stable isotope study. Other

Clinical nutrition (Edinburgh, … 2004 18 citações

[Environmental factors in the etiopathology of inflammatory bowel syndrome]. Review

Medycyna wieku rozwojowego 2004 1 citações

[Artificial nutrition in inflammatory bowel disease]. Review

Annali italiani di … 2004

Review article: nutrition and adult inflammatory bowel disease. Review

Alimentary pharmacology & … 2003 179 citações

Pharmacological nutrition in inflammatory bowel diseases. Other

Nutricion hospitalaria 2003

Inflammatory bowel diseases: principles of nutritional therapy. Review

Revista do Hospital … 2002 39 citações

Low serum concentrations of insulin-like growth factor-I in children with active Crohn disease: effect of enteral nutritional support and glutamine … RCT

Scandinavian journal of … 2002 28 citações

Enteral feeding. Other

Current opinion in … 2002 1 citações

Enteral feeding. Review

Current opinion in … 2002

Enteral nutritional therapy for inducing remission of Crohn's disease. Systematic Review

The Cochrane database … 2001 149 citações

Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. RCT

Journal of pediatric … 2000 187 citações

Nutrition in inflammatory bowel disease. Review

Current opinion in … 2000 21 citações

Glutamine supplementation and intestinal permeability in Crohn's disease. RCT

JPEN. Journal of … 2000 18 citações

Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. RCT

JPEN. Journal of … 1999 129 citações

Mucosal metabolism in ulcerative colitis and Crohn's disease. Other

Diseases of the … 1998 26 citações

[Enteral nutrition in acute Crohn disease]. Review

Zeitschrift fur Gastroenterologie 1998 18 citações

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. Review

FASEB journal : … 1997 170 citações

[Chronic inflammatory bowel diseases and nutrition]. Review

Schweizerische medizinische Wochenschrift. … 1996

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite superior: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Positive	--
Washed microbiota transplantation (WMT)	--	Positive	--
None	--	Positive	--
Phenylacetylglutamine (PAGln, measured)	--	Negative	262
Beclin1 constitutive activation (genetic)	--	Positive	--
None	--	Mixed	--
None	--	Negative	--
None	--	Mixed	--

Melhor horário: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interações Conhecidas

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Ingestão máxima tolerável: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does L-Glutamine help with Crohn's Disease?

Based on 3 studies with 200 participants, there is limited but promising evidence that L-Glutamine may support Crohn's Disease management. Our evidence grade is C (Some Evidence).

How much L-Glutamine should I take for Crohn's Disease?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Crohn's Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Crohn's Disease

Omega-3 Fatty Acids (EPA/DHA) C Curcumin C Butyrate (Sodium/Calcium Butyrate) C

L-Glutamine para outras condições

Irritable Bowel Syndrome (IBS) C Increased Intestinal Permeability (Leaky Gut) D

Veredito Rápido

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Evidence Strength52%

Moderate confidence

Detalhamento dos Estudos

RCT (5)Meta (2)Other (0)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Crohn's Disease

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.