Aloe Vera (Inner Leaf Gel) ： Ulcerative Colitis (UC)
DSingle RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
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D
結論
Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
Key Study Findings
Review
Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of natural therapies for IBD
In Vitro
1.0 weeks
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Dose: 272 µg/
vs: vehicle
Outcome: Ulcerative colitis severity
効果: None
None
対象集団: Mice (DSS-induced colitis model)
Controlled Clinical Trial
n=36
2 weeks
Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.
Dose: 20, 40, or 60 mg/kg b.wt.
vs: Dexamethasone 1 mg/kg and normal saline
Outcome: Clinical activity index, histological alterations, DNA, NO
効果: None
None
対象集団: Adult male Wistar rats with acetic acid-induced UC
Review
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Ulcerative colitis patients using CAM
Other
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Controlled Clinical Trial
Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.
Dose: None
vs: Control without aloe vera
Outcome: Anti-inflammatory, antioxidant, wound healing
効果: None
None
対象集団: Animal/cell wound healing models
Key Statistics
1
研究数
44
参加者数
↑
Positive
D
グレード
Referenced Papers
Current pharmaceutical biotechnology
2025
1 件の引用
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Other
Current issues in …
2023
3 件の引用
Phytomedicine : international …
2022
22 件の引用
Toxicology reports
2022
9 件の引用
Turkish journal of …
2022
3 件の引用
Journal of ethnopharmacology
2021
45 件の引用
Evidence-based complementary and …
2021
36 件の引用
Middle East journal …
2020
26 件の引用
Clinical nutrition research
2020
23 件の引用
Therapeutic advances in …
2020
21 件の引用
Medical science monitor …
2019
14 件の引用
Annals of gastroenterology
2016
41 件の引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 件の引用
Annals of gastroenterology
2015
135 件の引用
World journal of …
2014
23 件の引用
Alimentary pharmacology & …
2013
128 件の引用
Saudi journal of …
2012
138 件の引用
Alimentary pharmacology & …
2006
181 件の引用
Alimentary pharmacology & …
2004
264 件の引用
Health news (Waltham, …
2004
1 件の引用
BioFactors (Oxford, England)
2003
38 件の引用
The European journal …
1998
62 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
- ibssupport:
- 100 mL twice daily for 1-3 months
- constipation:
- 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)
上限量： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| 272 µg/ | 1.0 weeks | Positive | -- |
| 20, 40, or 60 mg/kg b.wt. | 2 weeks | Positive | 36 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 2 g | 3 weeks | Positive | -- |
推奨摂取タイミング： Before meals; aloe latex should only be used short-term for constipation
Safety & Side Effects
報告されている副作用
- ⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
- ⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
- ⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
- ⚠ Allergic skin reactions in sensitive individuals
既知の相互作用
- ● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
- ● Diuretics (additive potassium loss with aloe latex)
- ● Diabetes medications (aloe may lower blood sugar; monitor glucose)
- ● Stimulant laxatives (additive laxative effect; avoid combining)
- ● Anticoagulants (theoretical interaction due to platelet effects)
耐容上限摂取量： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?
Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).
How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Ulcerative Colitis (UC)
Aloe Vera (Inner Leaf Gel) 他の症状・状態について
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