Aloe Vera (Inner Leaf Gel) için Ulcerative Colitis (UC)

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

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Sonuç

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Key Study Findings

Review

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Review of natural therapies for IBD

In Vitro 1.0 weeks

Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.

Dose: 272 µg/ vs: vehicle Outcome: Ulcerative colitis severity Etki: None None

Popülasyon: Mice (DSS-induced colitis model)

Controlled Clinical Trial n=36 2 weeks

Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.

Dose: 20, 40, or 60 mg/kg b.wt. vs: Dexamethasone 1 mg/kg and normal saline Outcome: Clinical activity index, histological alterations, DNA, NO Etki: None None

Popülasyon: Adult male Wistar rats with acetic acid-induced UC

Review

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Ulcerative colitis patients using CAM

Other

Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: None

Controlled Clinical Trial

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.

Dose: None vs: Control without aloe vera Outcome: Anti-inflammatory, antioxidant, wound healing Etki: None None

Popülasyon: Animal/cell wound healing models

Key Statistics

Çalışmalar

Katılımcılar

↑

Positive

Derece

Referenced Papers

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease. Review

Current pharmaceutical biotechnology 2025 1 atıf

Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium. Other

Current issues in … 2023 3 atıf

Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. Other

Phytomedicine : international … 2022 22 atıf

Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats. Other

Toxicology reports 2022 9 atıf

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. Review

Turkish journal of … 2022 3 atıf

Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier. Other

Journal of ethnopharmacology 2021 45 atıf

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats. Other

Evidence-based complementary and … 2021 36 atıf

The Healing Effect of Aloe Vera Gel on Acetic Acid-Induced Ulcerative Colitis in Rat. Other

Middle East journal … 2020 26 atıf

Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats. Other

Clinical nutrition research 2020 23 atıf

Complementary and alternative medications in the management of inflammatory bowel disease. Review

Therapeutic advances in … 2020 21 atıf

Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway. Other

Medical science monitor … 2019 14 atıf

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 atıf

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 atıf

Herbal and plant therapy in patients with inflammatory bowel disease. Review

Annals of gastroenterology 2015 135 atıf

Advances in treatment of ulcerative colitis with herbs: from bench to bedside. Review

World journal of … 2014 23 atıf

Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Systematic Review

Alimentary pharmacology & … 2013 128 atıf

Herbal medicine in the treatment of ulcerative colitis. Review

Saudi journal of … 2012 138 atıf

Review article: complementary and alternative therapies for inflammatory bowel disease. Review

Alimentary pharmacology & … 2006 181 atıf

Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. RCT

Alimentary pharmacology & … 2004 264 atıf

Aloe vera helps ulcerative colitis. Other

Health news (Waltham, … 2004 1 atıf

The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative … Other

BioFactors (Oxford, England) 2003 38 atıf

Medical therapy of inflammatory bowel disease for the 21st century. Review

The European journal … 1998 62 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
ibssupport:: 100 mL twice daily for 1-3 months
constipation:: 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)

Üst sınır: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
None	--	Mixed	--
272 µg/	1.0 weeks	Positive	--
20, 40, or 60 mg/kg b.wt.	2 weeks	Positive	36
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
2 g	3 weeks	Positive	--

En iyi alım zamanı: Before meals; aloe latex should only be used short-term for constipation

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
⚠ Allergic skin reactions in sensitive individuals

Bilinen Etkileşimler

● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
● Diuretics (additive potassium loss with aloe latex)
● Diabetes medications (aloe may lower blood sugar; monitor glucose)
● Stimulant laxatives (additive laxative effect; avoid combining)
● Anticoagulants (theoretical interaction due to platelet effects)

Tolere edilebilir üst alım: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?

Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).

How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?

Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Aloe Vera (Inner Leaf Gel)?

Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.

Related Evidence

Şu durum için diğer içerikler: Ulcerative Colitis (UC)

Curcumin B Omega-3 Fatty Acids (EPA/DHA) C Butyrate (Sodium/Calcium Butyrate) C Resistant Starch D

Aloe Vera (Inner Leaf Gel) diğer sağlık durumları için

Irritable Bowel Syndrome (IBS) C

Hızlı Değerlendirme

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Evidence Strength30%

Low confidence

Çalışma Dağılımı

RCT (1)Meta (0)Other (0)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Ulcerative Colitis (UC)

Daha Fazla Bilgi

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