Aloe Vera (Inner Leaf Gel) para Ulcerative Colitis (UC)
D Investigación Solo existe investigación preliminar (estudios de laboratorio, informes de casos).Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
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D
Conclusión
Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
Key Study Findings
Review
Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Review of natural therapies for IBD
In Vitro
1.0 weeks
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Dose: 272 µg/
vs: vehicle
Outcome: Ulcerative colitis severity
Efecto: None
None
Población: Mice (DSS-induced colitis model)
Controlled Clinical Trial
n=36
2 weeks
Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.
Dose: 20, 40, or 60 mg/kg b.wt.
vs: Dexamethasone 1 mg/kg and normal saline
Outcome: Clinical activity index, histological alterations, DNA, NO
Efecto: None
None
Población: Adult male Wistar rats with acetic acid-induced UC
Review
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Ulcerative colitis patients using CAM
Other
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Controlled Clinical Trial
Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.
Dose: None
vs: Control without aloe vera
Outcome: Anti-inflammatory, antioxidant, wound healing
Efecto: None
None
Población: Animal/cell wound healing models
Key Statistics
1
Estudios
44
Participantes
↑
Positive
D
Calificación
Referenced Papers
Current pharmaceutical biotechnology
2025
1 citas
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Other
Current issues in …
2023
3 citas
Phytomedicine : international …
2022
22 citas
Toxicology reports
2022
9 citas
Turkish journal of …
2022
3 citas
Journal of ethnopharmacology
2021
45 citas
Evidence-based complementary and …
2021
36 citas
Middle East journal …
2020
26 citas
Clinical nutrition research
2020
23 citas
Therapeutic advances in …
2020
21 citas
Medical science monitor …
2019
14 citas
Annals of gastroenterology
2016
41 citas
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 citas
Annals of gastroenterology
2015
135 citas
World journal of …
2014
23 citas
Alimentary pharmacology & …
2013
128 citas
Saudi journal of …
2012
138 citas
Alimentary pharmacology & …
2006
181 citas
Alimentary pharmacology & …
2004
264 citas
Health news (Waltham, …
2004
1 citas
BioFactors (Oxford, England)
2003
38 citas
The European journal …
1998
62 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
- ibssupport:
- 100 mL twice daily for 1-3 months
- constipation:
- 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)
Límite superior: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| 272 µg/ | 1.0 weeks | Positive | -- |
| 20, 40, or 60 mg/kg b.wt. | 2 weeks | Positive | 36 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 2 g | 3 weeks | Positive | -- |
Mejor momento para tomar: Before meals; aloe latex should only be used short-term for constipation
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
- ⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
- ⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
- ⚠ Allergic skin reactions in sensitive individuals
Interacciones conocidas
- ● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
- ● Diuretics (additive potassium loss with aloe latex)
- ● Diabetes medications (aloe may lower blood sugar; monitor glucose)
- ● Stimulant laxatives (additive laxative effect; avoid combining)
- ● Anticoagulants (theoretical interaction due to platelet effects)
Ingesta máxima tolerable: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?
Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).
How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Ulcerative Colitis (UC)
Aloe Vera (Inner Leaf Gel) para otras condiciones
References
- [1] Monika Joshi et al.. Curr Pharm Biotechnol. 2025. Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease. doi:10.2174/0113892010293150240415143650 PubMed
- [2] Do Yeong Kweon et al.. Curr Issues Mol Biol. 2023. Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium. doi:10.3390/cimb45020096 PubMed
- [3] Hui Jiang et al.. Phytomedicine. 2022. Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. doi:10.1016/j.phymed.2022.154403 PubMed
- [4] W O Babalola et al.. Toxicol Rep. 2022. Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats. doi:10.1016/j.toxrep.2022.03.048 PubMed
- [5] Alaattin Şen. Turk J Med Sci. 2022. Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. doi:10.55730/1300-0144.5482 PubMed
- [6] Gaofeng Shi et al.. J Ethnopharmacol. 2021. Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier. doi:10.1016/j.jep.2021.114108 PubMed
- [7] Mahvash Alizade Naini et al.. Evid Based Complement Alternat Med. 2021. Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats. doi:10.1155/2021/9945244 PubMed
- [8] Negar Hassanshahi et al.. Middle East J Dig Dis. 2020. The Healing Effect of Aloe Vera Gel on Acetic Acid-Induced Ulcerative Colitis in Rat. doi:10.34172/mejdd.2020.177 PubMed
- [9] Gholamreza Bahrami et al.. Clin Nutr Res. 2020. Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats. doi:10.7762/cnr.2020.9.3.223 PubMed
- [10] Sherman Picardo et al.. Therap Adv Gastroenterol. 2020. Complementary and alternative medications in the management of inflammatory bowel disease. doi:10.1177/1756284820927550 PubMed
- [11] Ling Gai et al.. Med Sci Monit. 2019. Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway. doi:10.12659/MSM.918935 PubMed
- [12] John K Triantafillidis et al.. Ann Gastroenterol. 2016. Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. doi:10.20524/aog.2016.0059 PubMed
- [13] Alyssa Parian et al.. Curr Pharm Des. 2016. Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. doi:10.2174/1381612822666151112145033 PubMed
- [14] Aikaterini Triantafyllidi et al.. Ann Gastroenterol. 2015. Herbal and plant therapy in patients with inflammatory bowel disease. PubMed
- [15] Ping Wan et al.. World J Gastroenterol. 2014. Advances in treatment of ulcerative colitis with herbs: from bench to bedside. doi:10.3748/wjg.v20.i39.14099 PubMed
- [16] S C Ng et al.. Aliment Pharmacol Ther. 2013. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. doi:10.1111/apt.12464 PubMed
- [17] Fei Ke et al.. Saudi J Gastroenterol. 2012. Herbal medicine in the treatment of ulcerative colitis. doi:10.4103/1319-3767.91726 PubMed
- [18] L Langmead et al.. Aliment Pharmacol Ther. 2006. Review article: complementary and alternative therapies for inflammatory bowel disease. doi:10.1111/j.1365-2036.2006.02761.x PubMed
- [19] L Langmead et al.. Aliment Pharmacol Ther. 2004. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. doi:10.1111/j.1365-2036.2004.01902.x PubMed
- [20] . Health News. 2004. Aloe vera helps ulcerative colitis. PubMed
- [21] Ludmila Korkina et al.. Biofactors. 2003. The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative … doi:10.1002/biof.5520180228 PubMed
- [22] M Robinson. Eur J Surg Suppl. 1998. Medical therapy of inflammatory bowel disease for the 21st century. doi:10.1080/11024159850191517 PubMed
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.